Positive variation of the MRI signal via intramolecular inclusion complexation of a C-2 functionalized β-cyclodextrin

2017 ◽  
Vol 15 (3) ◽  
pp. 564-569 ◽  
Author(s):  
I. Zgani ◽  
H. Idriss ◽  
C. Barbot ◽  
F. Djedaïni-Pilard ◽  
S. Petit ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Contrast Agent ◽  
Inclusion Complexation ◽  
Agent Based ◽  
Positive Variation

The synthesis of a contrast agent based on a β-cyclodextrin is reported. An enhancement of relaxivity in the presence of an intramolecular inclusion complex is observed.

scholarly journals A study on the imaging characteristics of Gold nanoparticles as a contrast agent in X-ray computed tomography

2017 ◽  
Vol 23 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Asghar Mesbahi ◽  
Fatemeh Famouri ◽  
Mohammad Johari Ahar ◽  
Maryam Olade Ghaffari ◽  
Seyed Mostafa Ghavami
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Contrast Agent ◽  
Hounsfield Unit ◽  
Ct Number ◽  
Agent Based ◽  
X Ray ◽  
Imaging Characteristics ◽  
Tube Potential ◽  
X Ray Computed

AbstractAim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom.Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs.Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively.Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.

scholarly journals Guest-Host Inclusion Complex Formation of 2-, 3-, and 4-Aminobenzoic Acids with Native and Modified Cyclodextrins

2016 ◽  
Vol 69 ◽  
pp. 10-21 ◽  
Author(s):  
Narayanasamy Rajendiran ◽  
J. Thulasidhasan ◽  
M. Jude Jenita
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexation ◽  
Aminobenzoic Acid ◽  
Time Resolved ◽  
H Nmr ◽  
Buffer Solutions ◽  
Aminobenzoic Acids ◽  
Modified Cyclodextrins ◽  
Ft Ir ◽  
Uv Visible

The inclusion complexation of 2-aminobenzoic acid (2ABA), 3-aminobenzoic acid (3ABA), and 4-aminobenzoic acid (4ABA) with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), hydroxypropyl-α-cyclodextrin (HP-α-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were studied in buffer solutions of differentpHs (pH~1 andpH~7) and it was carried out using UV-Visible, steady-state and time-resolved fluorescence. Dual fluorescence was observed for all the compounds in aqueous and CD medium. All the ABAs forms 1:1 inclusion complex at pH ~ 1 solution and mixture of 1:1 and 1:2 inclusion complex at pH ~7. With CDs, dual luminescence appeared at pH ~ 1 indicates, both NH3+and COOH groups are present in the interior of the CDs cavities. FT-IR,1H NMR, results suggest ABAs formed a stable inclusion complex with the CDs.

An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging

2020 ◽  
Vol 8 (31) ◽  
pp. 6956-6963
Author(s):  
Peisen Zhang ◽  
Zihua Wang ◽  
Yiyang Wang ◽  
Yuqing Wang ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Imaging ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Agent Based ◽  
Metal Chelating ◽  
Chelating Polymer

A zwitterionic MRI contrast agent Gd-PAA with exceptionally high r1 was designed for hepatorenal angiography and tumor imaging.

scholarly journals Electric-field responsive contrast agent based on liquid crystals and magnetic nanoparticles

AIP Advances ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. 056731 ◽  
Author(s):  
Lamar O. Mair ◽  
Luz J. Martinez-Miranda ◽  
Lynn K. Kurihara ◽  
Aleksandar Nacev ◽  
Ryan Hilaman ◽  
...  
Keyword(s):  
Liquid Crystals ◽  
Magnetic Nanoparticles ◽  
Electric Field ◽  
Contrast Agent ◽  
Agent Based

scholarly journals Novel Span-PEG Multifunctional Ultrasound Contrast Agent Based on CNTs as a Magnetic Targeting Factor and a Drug Carrier

ACS Omega ◽  
2020 ◽  
Vol 5 (49) ◽  
pp. 31525-31534
Author(s):  
Jie Zhang ◽  
Zhongtao Liu ◽  
Shujing Zhou ◽  
Yang Teng ◽  
Xiangyu Zhang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Drug Carrier ◽  
Ultrasound Contrast Agent ◽  
Magnetic Targeting ◽  
Agent Based ◽  
Ultrasound Contrast

Inclusion complexation involving sugar-containing species: β-cyclodextrin and sugar surfactants

2004 ◽  
Vol 82 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Vincent C Reinsborough ◽  
Vanessa C Stephenson
Keyword(s):  
Surface Tension ◽  
Critical Micelle Concentration ◽  
Inclusion Complex ◽  
Computer Modeling ◽  
Inclusion Complexation ◽  
Binding Constants ◽  
Guest Molecules ◽  
Sugar Moiety ◽  
G 12 ◽  
Concentration Surface

Surface tension, proton NMR, and computer modeling studies were undertaken in nonionic alkylpolyglycoside (APG) solutions containing β-cyclodextrin (β-CD) with a view to characterize the inclusion complexes formed and to determine if the sugar entities of the host and guest molecules played a significant role in the process. The APGs investigated were four glucopyranosides (octyl G8, decyl G10, dodecyl G12, tetradecyl G14) and two maltosides (decyl M10, dodecyl M12). Critical micelle concentrations (CMC) were obtained in the surfactant–β-CD systems, which in all cases increased with increasing β-CD concentration. The 1:1 APG–β-CD inclusion complex was principally formed with binding constants of 425 (mol L–1)–1 for the G12 complex, 340 (mol L–1)–1 for the G10 complex, and 125 (mol L–1)–1 for the M12 complex. The preferred configuration of the G-12–β-CD complex has the surfactant tail coiled in the CD cavity with the surfactant sugar moiety sealing off the narrower opening of the CD torus.Key words: alkylpolyglycoside, β-cyclodextrin, NMR, critical micelle concentration, surface tension.

scholarly journals A new X-ray contrast agent based on highly stable gum arabic-gold nanoparticles synthesised in deep eutectic solvent

2014 ◽  
Vol 10 (12) ◽  
pp. 911-924 ◽  
Author(s):  
Shoaleh Shahidi ◽  
Shiva Iranpour ◽  
Pooya Iranpour ◽  
Ali Asghar Alavi ◽  
Farzaneh Aghakhani Mahyari ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agent ◽  
Deep Eutectic Solvent ◽  
Gum Arabic ◽  
Agent Based ◽  
X Ray

Polypseudorotaxane Hydrogels Based on F127 Block-Selected Inclusion Complexation with α-Cyclodextrin

2012 ◽  
Vol 482-484 ◽  
pp. 1898-1903
Author(s):  
Ying Xue Zhou ◽  
Xiao Dong Fan ◽  
Dan Xue
Keyword(s):  
Thermal Stability ◽  
Inclusion Complex ◽  
Inclusion Complexation ◽  
Wide Angle ◽  
Acryloyl Chloride ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Thermal Stability Of ◽  
Channel Type

Supramolecular hydrogels were formed through F127, acryloyl chloride modified F127 inclusion complex with α-cyclodextrin, respectively. The structure of modified copolymers and inclusion complex was characterized by Fourier transform infrared spectroscopy (FTIR) and hydrogen nuclear magnetic resonance (1H-NMR). Hydrogels formed from supramolecular inclusion are imparted channel-type structure investigated by wide angle x-ray diffraction (WAXRD). Differential scanning calorimetry (DSC) and TG experiments showed that thermal stability of hydrogels depend on the nature of axis polymer. The relative model was proposed to elucidate the inclusion complexes and hydrogels formation.

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