A linear hydroxymethyl tetramate undergoes an acetylation–elimination process for exocyclic methylene formation in the biosynthetic pathway of pyrroindomycins

2017 ◽  
Vol 15 (1) ◽  
pp. 88-91 ◽  
Author(s):  
Qingfei Zheng ◽  
Zhuhua Wu ◽  
Peng Sun ◽  
Dandan Chen ◽  
Zhenhua Tian ◽  
...  
Keyword(s):  
Biosynthetic Pathway ◽  
Elimination Process ◽  
Exocyclic Methylene

The exocyclic methylene formation involved in pyrroindomycin biosynthesis is mediated by an enzymatic acetylation–elimination process.

New insights into heparan sulphate biosynthesis from the study of mutant mice

2002 ◽  
Vol 69 ◽  
pp. 47-57 ◽  
Author(s):  
Catherine L. R. Merry ◽  
John T. Gallagher
Keyword(s):  
Growth Factors ◽  
Biosynthetic Pathway ◽  
Heparan Sulphate ◽  
Mutant Mice ◽  
Gene Products ◽  
Multiple Gene ◽  
Adhesion Proteins ◽  
Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

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