scholarly journals Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction

2017 ◽  
Vol 15 (2) ◽  
pp. 301-305 ◽  
Author(s):  
Liliana Becerra-Figueroa ◽  
Elodie Brun ◽  
Michael Mathieson ◽  
Louis J. Farrugia ◽  
Claire Wilson ◽  
...  
Keyword(s):  
Michael Reaction ◽  
Diastereoselective Synthesis ◽  
Simple Method ◽  
Reaction Proceeds

A rapid and simple method to access trifluoromethylated 1,3-dioxanes by a sequence of addition/oxa-Michael reaction has been developed; the reaction proceeds smoothly with excellent stereoselectivity.

Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael-Michael Reaction

Synthesis ◽  
2011 ◽  
Vol 2011 (12) ◽  
pp. 1984-1987 ◽  
Author(s):  
Jinxing Ye ◽  
Juanjuan Yang ◽  
Huicai Huang ◽  
Zhichao Jin ◽  
Wenbin Wu
Keyword(s):  
Michael Reaction ◽  
Diastereoselective Synthesis

Iodotrimethylsilane Induced Diastereoselective Synthesis of Tetrahydropyranones by a Tandem Knoevenagel—Michael Reaction.

ChemInform ◽  
2003 ◽  
Vol 34 (52) ◽  
Author(s):  
Gowravaram Sabitha ◽  
G. S. Kiran Kumar Reddy ◽  
M. Rajkumar ◽  
J. S. Yadav ◽  
K. V. S. Ramakrishna ◽  
...  
Keyword(s):  
Michael Reaction ◽  
Diastereoselective Synthesis

scholarly journals Oxidative Asymmetric Formal Aza-Diels–Alder Reactions of Tetrahydro-β-carboline with Enones in the Synthesis of Indoloquinolizidine-2-ones

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2228 ◽  
Author(s):  
Xiang Wu ◽  
Shi-Bao Zhao ◽  
Lang-Lang Zheng ◽  
You-Gui Li
Keyword(s):  
Oxidative Dehydrogenation ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Butyl Hydroperoxide ◽  
Unsaturated Ketones ◽  
Tert Butyl ◽  
Diels Alder Reaction ◽  
Tert Butyl Hydroperoxide ◽  
Reaction Proceeds

Ru-catalyzed tandem amine oxidative dehydrogenation/formal aza-Diels–Alder reaction for enantio- and diastereoselective synthesis of indoloquinolizidine-2-ones from tetrahydro-β-carbolines and α,β-unsaturated ketones is described. The reaction proceeds via tandem ruthenium-catalyzed amine dehydrogenation using tert-butyl hydroperoxide (TBHP) as the oxidant and a chiral thiourea-catalyzed formal aza-[4 + 2] cycloaddition, providing a step-economical strategy for the synthesis of these valuable heterocyclic products.

scholarly journals Intramolecular Michael Reaction in Diastereoselective Synthesis of dl-Griseofulvin.

1991 ◽  
Vol 39 (11) ◽  
pp. 3048-3050 ◽  
Author(s):  
Yasuo TAKEUCHI ◽  
Ikuo WATANABE ◽  
Hideo TOMOZANE ◽  
Kuniko HASHIGAKI ◽  
Masatoshi YAMATO
Keyword(s):  
Michael Reaction ◽  
Diastereoselective Synthesis

scholarly journals Enantioselective Synthesis of Chromanones Bearing an α,α-Disubstituted α-Amino Acid Moiety via Decarboxylative Michael Reaction

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2565 ◽  
Author(s):  
Jan Bojanowski ◽  
Lesław Sieroń ◽  
Anna Albrecht
Keyword(s):  
Amino Acid ◽  
Acid Derivative ◽  
Michael Addition ◽  
Structural Unit ◽  
Michael Reaction ◽  
Enantioselective Synthesis ◽  
Amino Acid Derivative ◽  
Acid Moiety ◽  
Amino Acid Moiety ◽  
Reaction Proceeds

In this manuscript, a novel, decarboxylative Michael reaction between α-substituted azlactones and chromone-3-carboxylic acids is described. The reaction proceeds in a sequence Michael addition followed by decarboxylative deprotonation, and it results in the formation of chromanones bearing an azlactone structural unit. The possibility of transforming an azlactone moiety into a protected α,α-disubstituted α-amino acid derivative is also demonstrated.

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