Facilitation of DNA self-assembly by relieving the torsional strains between building blocks

2017 ◽  
Vol 15 (2) ◽  
pp. 465-469 ◽  
Author(s):  
Weili Shen ◽  
Qing Liu ◽  
Baoquan Ding ◽  
Changqing Zhu ◽  
Zhiyong Shen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Base Pairs ◽  
Dna Motifs ◽  
Torsional Strain ◽  
High Uniformity ◽  
Self Assembled ◽  
Paranemic Crossover

Overwound and underwound paranemic crossover (PX) DNA motifs have been self-assembled to generate high uniformity lattices, by adjusting the number of base pairs in the JX region adjacent to the PX structure to relieve torsional strain.

scholarly journals Self-Assembly of Shape-Tunable Oblate Colloidal Particles into Orientationally Ordered Crystals, Glassy Crystals and Plastic Crystals

Soft Matter ◽  
2021 ◽  
Author(s):  
Jiawei Lu ◽  
Xiangyu Bu ◽  
Xinghua Zhang ◽  
Bing Liu
Keyword(s):  
Crystal Structures ◽  
Self Assembly ◽  
Colloidal Particles ◽  
Building Blocks ◽  
Fundamental Question ◽  
The Self ◽  
Plastic Crystals ◽  
Self Assembled ◽  
Glassy Crystals ◽  
The Relationship

The shapes of colloidal particles are crucial to the self-assembled superstructures. Understanding the relationship between the shapes of building blocks and the resulting crystal structures is an important fundamental question....

Self-Assembly of Proteins into Three-Dimensional Structures Using Bio-Conjugation

2014 ◽  
Vol 1663 ◽  
Author(s):  
Garima Thakur ◽  
Kovur Prashanthi ◽  
Thomas Thundat
Keyword(s):  
Self Assembly ◽  
Three Dimensional ◽  
Gold Surface ◽  
Building Blocks ◽  
Growth Conditions ◽  
Base Layer ◽  
Chemical Structures ◽  
Molecular Building Blocks ◽  
Ring Structures ◽  
Self Assembled

ABSTRACTSelf–assembly of molecular building blocks provides an interesting route to produce well-defined chemical structures. Tailoring the functionalities on the building blocks and controlling the time of self-assembly could control the properties as well as the structure of the resultant patterns. Spontaneous self-assembly of biomolecules can generate bio-interfaces for myriad of potential applications. Here we report self-assembled patterning of human serum albumin (HSA) protein in to ring structures on a polyethylene glycol (PEG) modified gold surface. The structure of the self-assembled protein molecules and kinetics of structure formation entirely revolved around controlling the nucleation of the base layer. The formation of different sizes of ring patterns is attributed to growth conditions of the PEG islands for bio-conjugation. These assemblies might be beneficial in forming structurally ordered architectures of active proteins such as HSA or other globular proteins.

scholarly journals Self-assembled liposomal nanoparticles in photodynamic therapy

2013 ◽  
Vol 5 (3) ◽  
Author(s):  
Magesh Sadasivam ◽  
Pinar Avci ◽  
Gaurav K. Gupta ◽  
Shanmugamurthy Lakshmanan ◽  
Rakkiyappan Chandran ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Building Blocks ◽  
Dimensional Structure ◽  
3 Dimensional ◽  
Drug Delivery Vehicles ◽  
Judicious Choice ◽  
Delivery Vehicles ◽  
Self Assembled ◽  
Liposomal Nanoparticles

AbstractPhotodynamic therapy (PDT) employs the combination of non-toxic photosensitizers (PS) together with harmless visible light of the appropriate wavelength to produce reactive oxygen species that kill unwanted cells. Because many PS are hydrophobic molecules prone to aggregation, numerous drug delivery vehicles have been tested to solubilize these molecules, render them biocompatible and enhance the ease of administration after intravenous injection. The recent rise in nanotechnology has markedly expanded the range of these nanoparticulate delivery vehicles beyond the well-established liposomes and micelles. Self-assembled nanoparticles are formed by judicious choice of monomer building blocks that spontaneously form a well-oriented 3-dimensional structure that incorporates the PS when subjected to the appropriate conditions. This self-assembly process is governed by a subtle interplay of forces on the molecular level. This review will cover the state of the art in the preparation and use of self-assembled liposomal nanoparticles within the context of PDT.

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

2017 ◽  
Vol 15 (5) ◽  
pp. 1106-1109 ◽  
Author(s):  
Gaia Fumagalli ◽  
Michael S. Christodoulou ◽  
Benedetta Riva ◽  
Inigo Revuelta ◽  
Cristina Marucci ◽  
...  
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Self Assembled

The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported.

scholarly journals Reorganization of Self-Assembled DNA-Based Polymers Using Orthogonally Addressable Building Blocks

2021 ◽  
Author(s):  
Serena Gentile ◽  
Erica Del Grosso ◽  
Leonard J. Prins ◽  
Francesco Ricci
Keyword(s):  
Self Assembly ◽  
Rational Design ◽  
Building Blocks ◽  
Binding Domain ◽  
Non Covalent Interactions ◽  
Sticky Ends ◽  
Self Assembled ◽  
Block Structures ◽  
Covalent Interactions

Taking advantage of the addressability and programmability of DNA/DNA non-covalent interactions we report here the rational design of orthogonal DNA-based addressable tiles that self-assemble into polymer-like structures that can be reconfigured and reorganized by external inputs. The different tiles share the same 5-nucleotide sticky ends responsible for self-assembly but are rationally designed to contain a specific regulator-binding domain that can be orthogonally targeted by different DNA regulator strands (activators and inhibitors). We show that by sequentially adding specific activators and inhibitors it is possible to re-organize in a dynamic and reversible way the formed polymer-like structures to display well-defined distributions: homopolymers made of a single tile, random polymers in which different tiles are distributed randomly and block structures in which the tiles are organized in segments.

scholarly journals Mono-patchy zwitterionic microcolloids as building blocks for pH-controlled self-assembly

Soft Matter ◽  
2019 ◽  
Vol 15 (11) ◽  
pp. 2430-2438 ◽  
Author(s):  
Fatemeh Naderi Mehr ◽  
Dmitry Grigoriev ◽  
Nikolay Puretskiy ◽  
Alexander Böker
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Free Surfaces ◽  
Patchy Particles ◽  
Self Assembled ◽  
Oppositely Charged ◽  
Ph Controlled

Not only in theory but also experimentally, mono-patchy particles can be self-assembled via pH-controlled electrostatic attractions between their oppositely charged patchy and patch-free surfaces.

scholarly journals Multilayer Self-Assemblies as Electronic and Optical Materials

1997 ◽  
Vol 488 ◽  
Author(s):  
DeQuan Li ◽  
M. Lütt ◽  
Xiaobo Shi ◽  
M. R. Fitzsimmons
Keyword(s):  
Thin Film ◽  
Self Assembly ◽  
Film Growth ◽  
Building Blocks ◽  
Layer Growth ◽  
The Self ◽  
Growth Surface ◽  
Layer By Layer ◽  
Self Assembled ◽  
Average Electron

AbstractThe layer-by-layer growth of film structures consisting of sequential depositions of oppositely charged polymers and macrocycles (ring-shaped molecules) have been constructed using molecular self-assembly techniques. These self-assembled thin films were characterized with X-ray reflectometry, which yielded (1) the average electron density, (2) the average thicknesses, and (3) the roughness of the growth surface of the self-assembled multilayer of macrocycles and polymers. These observations suggest that inorganic-organic interactions play an important role during the initial stages of thin-film growth, but less so as the thin film becomes thicker. Optical absorption techniques were also used to characterize the self-assembled multilayers. Phorphyrin and phthalocyanine derivatives were chosen as the building blocks of the self-assembled multilayers because of their interesting optical properties.

Self-assembled plasmonic metamaterials

Nanophotonics ◽  
2013 ◽  
Vol 2 (3) ◽  
pp. 211-240 ◽  
Author(s):  
Stefan Mühlig ◽  
Alastair Cunningham ◽  
José Dintinger ◽  
Toralf Scharf ◽  
Thomas Bürgi ◽  
...  
Keyword(s):  
Self Assembly ◽  
Degrees Of Freedom ◽  
Building Blocks ◽  
Spatial Arrangement ◽  
Plasmonic Nanostructures ◽  
Bottom Up ◽  
Unit Cells ◽  
Amorphous Structures ◽  
Self Assembled ◽  
Novel Applications

AbstractNowadays for the sake of convenience most plasmonic nanostructures are fabricated by top-down nanofabrication technologies. This offers great degrees of freedom to tailor the geometry with unprecedented precision. However, it often causes disadvantages as well. The structures available are usually planar and periodically arranged. Therefore, bulk plasmonic structures are difficult to fabricate and the periodic arrangement causes undesired effects, e.g., strong spatial dispersion is observed in metamaterials. These limitations can be mitigated by relying on bottom-up nanofabrication technologies. There, self-assembly methods and techniques from the field of colloidal nanochemistry are used to build complex functional unit cells in solution from an ensemble of simple building blocks, i.e., in most cases plasmonic nanoparticles. Achievable structures are characterized by a high degree of nominal order only on a short-range scale. The precise spatial arrangement across larger dimensions is not possible in most cases; leading essentially to amorphous structures. Such self-assembled nanostructures require novel analytical means to describe their properties, innovative designs of functional elements that possess a desired near- and far-field response, and entail genuine nanofabrication and characterization techniques. Eventually, novel applications have to be perceived that are adapted to the specifics of the self-assembled nanostructures. This review shall document recent progress in this field of research. Emphasis is put on bottom-up amorphous metamaterials. We document the state-of-the-art but also critically assess the problems that have to be overcome.

scholarly journals Bifurcation of self-assembly pathways to sheet or cage controlled by kinetic template effect

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Leonardo Hayato Foianesi-Takeshige ◽  
Satoshi Takahashi ◽  
Tomoki Tateishi ◽  
Ryosuke Sekine ◽  
Atsushi Okazawa ◽  
...  
Keyword(s):  
Self Assembly ◽  
Early Stage ◽  
Building Blocks ◽  
The Self ◽  
Numerical Analyses ◽  
Template Effect ◽  
Self Assembled ◽  
Assembly Pathways ◽  
Formation Step

Abstract The template effect is a key feature to control the arrangement of building blocks in assemblies, but its kinetic nature remains elusive compared to the thermodynamic aspects, with the exception of very simple reactions. Here we report a kinetic template effect in a self-assembled cage composed of flexible ditopic ligands and Pd(II) ions. Without template anion, a micrometer-sized sheet is kinetically trapped (off-pathway), which is converted into the thermodynamically most stable cage by the template anion. When the template anion is present from the start, the cage is selectively produced by the preferential cyclization of a dinuclear intermediate (on-pathway). Quantitative and numerical analyses of the self-assembly of the cage on the on-pathway revealed that the accelerating effect of the template is stronger for the early stage reactions of the self-assembly than for the final cage formation step itself, indicating the kinetic template effect.

scholarly journals Mikto-Arm Stars as Soft-Patchy Particles: From Building Blocks to Mesoscopic Structures

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1114
Author(s):  
Petra Bačová ◽  
Dimitris G. Mintis ◽  
Eirini Gkolfi ◽  
Vagelis Harmandaris
Keyword(s):  
Polymer Nanocomposites ◽  
Self Assembly ◽  
Nearest Neighbor ◽  
Building Blocks ◽  
Model System ◽  
The Self ◽  
Mutual Orientation ◽  
Patchy Particles ◽  
Self Assembled ◽  
The Individual

We present an atomistic molecular dynamics study of self-assembled mikto-arm stars, which resemble patchy-like particles. By increasing the number of stars in the system, we propose a systematic way of examining the mutual orientation of these fully penetrable patchy-like objects. The individual stars maintain their patchy-like morphology when creating a mesoscopic (macromolecular) self-assembled object of more than three stars. The self-assembly of mikto-arm stars does not lead to a deformation of the stars, and their shape remains spherical. We identified characteristic sub-units in the self-assembled structure, differing by the mutual orientation of the nearest neighbor stars. The current work aims to elucidate the possible arrangements of the realistic, fully penetrable patchy particles in polymer matrix and to serve as a model system for further studies of nanostructured materials or all-polymer nanocomposites using the mikto-arm stars as building blocks.

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