Recent advances in the tandem reaction of azides with alkynes or alkynols

2016 ◽  
Vol 14 (48) ◽  
pp. 11317-11331 ◽  
Author(s):  
Xian-Rong Song ◽  
Yi-Feng Qiu ◽  
Xue-Yuan Liu ◽  
Yong-Min Liang
Keyword(s):  
Tandem Reaction ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Nitrogen Containing Compounds ◽  
Significant Attention

Over the past few decades, the development of versatile methodologies to employ azides as aminating agents for the formation of nitrogen-containing compounds has attracted significant attention in synthetic chemistry.

scholarly journals Recent advances in copper-catalyzed asymmetric coupling reactions

2015 ◽  
Vol 11 ◽  
pp. 2600-2615 ◽  
Author(s):  
Fengtao Zhou ◽  
Qian Cai
Keyword(s):  
Recent Progress ◽  
Alkyl Halides ◽  
Coupling Reactions ◽  
Ring Systems ◽  
The Past ◽  
Recent Advances ◽  
Asymmetric Coupling ◽  
Significant Attention

Copper-catalyzed (or -mediated) asymmetric coupling reactions have received significant attention over the past few years. Especially the coupling reactions of aryl or alkyl halides with nucleophiles became a very powerful tool for the formation of C–C, C–N, C–O and other carbon–heteroatom bonds as well as for the construction of heteroatom-containing ring systems. This review summarizes the recent progress in copper-catalyzed asymmetric coupling reactions for the formation of C–C and carbon–heteroatom bonds.

Tertiary Enamides: Versatile and Available Substrates in Synthetic Chemistry

2019 ◽  
Vol 16 (1) ◽  
pp. 70-97 ◽  
Author(s):  
Xiaohua Cai ◽  
Mengzhi Yang ◽  
Hui Guo
Keyword(s):  
Chemical Reaction ◽  
Coupling Reaction ◽  
Building Blocks ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Complex Building ◽  
Group A ◽  
Unique Stability ◽  
Made In

Background: Enamines and their variant enamides as powerful and versatile synthons have attracted great attention in synthetic chemistry. Enamides display unique stability and reduce enaminic reactivity in view of the electron-withdrawing effect of N-acyl group. A great deal of satisfactory achievements in the synthesis and application of enamides has been made in recent years. Especially, tertiary enamides without N-H bond regarded as low reactivity of compounds in the past can act as excellent nucleophiles to react with electrophiles for the construction of various nitrous molecules. </P><P> Objective: This review focuses on recent advances on tertiary enamides in the synthetic strategies and applications including addition, coupling reaction, functionalization and electro- or photo-chemical reaction. Conclusion: Tertiary enamides as electron-deficient nucleophiles display a satisfactory balance between stability and reactivity to offer multiple opportunities for the construction of various functionalized nitrogencontaining compounds. Further exploration of the reactive mechanisms involved tertiary enamides and the development of novel and efficient transformations to generate ever more complex building blocks starting from tertiary enamides are particularly worth pursuing.

N,N-Dimethylformamide (DMF): An Inexpensive and Attractive Reactant

2021 ◽  
Vol 25 ◽  
Author(s):  
Xiao-hua CAI ◽  
Hui GUO
Keyword(s):  
Building Block ◽  
Polar Solvent ◽  
Raw Material ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Synthetic Reactions ◽  
Simple Atom ◽  
Made In ◽  
Versatile Reagent

: The development of simple, atom-economical, and sustainable methodologies for the construction of various functional molecules from easily available substrates has been of great interest in synthetic chemistry. N,N-dimethylformamide (DMF) is an inexpensive, abundant solvent and industrial raw material. It is considered as an effective polar solvent and a versatile reagent in synthetic transformations. During the past few decades, many significant and attractive achievements have been made in the fields of DMF as a reactant. The mini-review will mainly summarize recent advances in the applicants of DMF as a multipurpose building block in synthetic reactions.

Integrating Bioinformatics Strategies in Cancer Immunotherapy: Current and Future Perspectives

2020 ◽  
Vol 23 (8) ◽  
pp. 687-698 ◽  
Author(s):  
Houda N. Washah ◽  
Elliasu Y. Salifu ◽  
Opeyemi Soremekun ◽  
Ahmed A. Elrashedy ◽  
Geraldene Munsamy ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Therapeutic Potential ◽  
Cell Cancer ◽  
Full Potential ◽  
Future Perspectives ◽  
The Past ◽  
Bioinformatics Tools ◽  
Treatment Paradigm ◽  
Immunotherapy Of Cancer ◽  
Significant Attention

For the past few decades, the mechanisms of immune responses to cancer have been exploited extensively and significant attention has been given into utilizing the therapeutic potential of the immune system. Cancer immunotherapy has been established as a promising innovative treatment for many forms of cancer. Immunotherapy has gained its prominence through various strategies, including cancer vaccines, monoclonal antibodies (mAbs), adoptive T cell cancer therapy, and immune checkpoint therapy. However, the full potential of cancer immunotherapy is yet to be attained. Recent studies have identified the use of bioinformatics tools as a viable option to help transform the treatment paradigm of several tumors by providing a therapeutically efficient method of cataloging, predicting and selecting immunotherapeutic targets, which are known bottlenecks in the application of immunotherapy. Herein, we gave an insightful overview of the types of immunotherapy techniques used currently, their mechanisms of action, and discussed some bioinformatics tools and databases applied in the immunotherapy of cancer. This review also provides some future perspectives in the use of bioinformatics tools for immunotherapy.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Recent advances in storage and flooding theory

1969 ◽  
Vol 1 (1) ◽  
pp. 90-110 ◽  
Author(s):  
J. Gani
Keyword(s):  
Queueing Theory ◽  
Applied Probability ◽  
The Past ◽  
Continuous Flows ◽  
Recent Advances ◽  
A Minor ◽  
Queueing Processes ◽  
Theory Of Storage ◽  
Storage Processes

The theory of storage processes, originally formulated by Moran [1] in 1954, has developed in the past fourteen years into a minor subfield of Applied Probability, closely allied to queueing theory. While dam models with discrete inputs are analogous to queueing processes, the essentially continuous nature of water inflows has distinguished generalized storage processes from queues. Indeed, some of the most complex of storage problems have arisen in the case of continuous flows.

More Than Cheating: Deception, IRB Shopping, and the Normative Legitimacy of IRBs

2012 ◽  
Vol 40 (4) ◽  
pp. 990-996 ◽  
Author(s):  
Ryan Spellecy ◽  
Thomas May
Keyword(s):  
Informed Consent ◽  
Multicenter Trial ◽  
Federal Regulations ◽  
Approval Process ◽  
Emergency Research ◽  
Moral Issues ◽  
The Past ◽  
Significant Attention

Deception, cheating, and loopholes within the IRB approval process have received significant attention in the past several years. Surveys of clinical researchers indicate common deception ranging from omitting information to outright lying, and controversy surrounding the FDA's decision not to ban “IRB shopping” (the practice of submitting protocols to multiple IRBs until one is found that will approve the protocol) has raised legitimate concerns about the integrity of the IRB process. One author has described a multicenter trial as being withdrawn from consideration at one institution when rejection was imminent, in order to avoid informing other IRBs reviewing the protocol of the study's rejection (a requirement under the federal regulations for emergency research with an exception from informed consent). This practice and IRB shopping seem at odds with the spirit, if not the “letter,” of the regulations. While at first blush these practices seem to cast aspersions on the integrity of clinical researchers, the moral issues raised go deeper than the ethics of cheating.

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

2015 ◽  
Vol 44 (11) ◽  
pp. 3418-3430 ◽  
Author(s):  
J. Wencel-Delord ◽  
A. Panossian ◽  
F. R. Leroux ◽  
F. Colobert
Keyword(s):  
Chiral Compounds ◽  
The Past ◽  
Recent Advances ◽  
New Concepts ◽  
Axially Chiral ◽  
Recent Developments ◽  
Synthetic Routes

Over the past decade the field of the synthesis of axially chiral compounds has been rapidly expanding. Not only key advances have been achieved concerning the already established strategies but also new synthetic routes have been devised. This review showcases the recent developments in this domain.

scholarly journals Recent Advances of Actinomycetes

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 134
Author(s):  
Eung-Soo Kim
Keyword(s):  
Secondary Metabolites ◽  
Human Medicine ◽  
The Past ◽  
Recent Advances

The discovery and development of actinomycete secondary metabolites (ASMs) have played pivotal roles in the fields of human medicine and its related biotechnology sectors over the past several decades [...]

Recent Advances on Visible-Light-Promoted Copper Catalysis in Organic Reactions

Synthesis ◽  
2021 ◽  
Author(s):  
Yang Xiong ◽  
Sijia Li ◽  
Haijing Xiao ◽  
Guozhu Zhang
Keyword(s):  
Visible Light ◽  
Copper Complexes ◽  
Rapid Development ◽  
Cost Effective ◽  
Organic Reactions ◽  
Copper Catalysis ◽  
Synthetic Chemistry ◽  
Recent Advances ◽  
Intense Activity

In recent years, visible-light-mediated copper photocatalysis have emerged as an attractive strategy for the diverse constructions of basic bonds in an ecologically benign and cost-effective fashion. The intense activity and increasing work of these areas stimulated the exploit of the distinctive properties of copper photocatalysis and the rapid development and expansion of their applications. In this review, we focus on introducing a series of significant achievements in copper complexes as standalone photocatalysis in organic reactions to make an attempt to exhibit their potential capabilities and high flexibilities in synthetic chemistry.

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