Enantioselective synthesis of α,α-disubstituted α-amino acids via direct catalytic asymmetric addition of acetonitrile to α-iminoesters

Shaoquan Lin; Naoya Kumagai; Masakatsu Shibasaki

doi:10.1039/c6ob01874b

Enantioselective synthesis of α,α-disubstituted α-amino acids via direct catalytic asymmetric addition of acetonitrile to α-iminoesters

Organic & Biomolecular Chemistry ◽

10.1039/c6ob01874b ◽

2016 ◽

Vol 14 (41) ◽

pp. 9725-9730 ◽

Cited By ~ 13

Author(s):

Shaoquan Lin ◽

Naoya Kumagai ◽

Masakatsu Shibasaki

Keyword(s):

Amino Acids ◽

Enantioselective Synthesis ◽

Asymmetric Addition ◽

Carbene Complexes ◽

Enantioselective Addition ◽

Catalytic Asymmetric

Chiral N-heterocyclic carbene complexes of [Ir(cod)(OMe)]2 in combination with Barton's base enabled direct enantioselective addition of acetonitrile to α-iminoesters.

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Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles

Angewandte Chemie ◽

10.1002/ange.201007145 ◽

2011 ◽

Vol 123 (11) ◽

pp. 2621-2625 ◽

Cited By ~ 32

Author(s):

Ke Zheng ◽

Chengkai Yin ◽

Xiaohua Liu ◽

Lili Lin ◽

Xiaoming Feng

Keyword(s):

Enantioselective Synthesis ◽

Asymmetric Addition ◽

Dicarbonyl Compounds ◽

Enol Ethers ◽

Catalytic Asymmetric ◽

Alkyl Enol Ethers

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ChemInform Abstract: Asymmetric Addition of Amines to α,β-Unsaturated Esters and Nitriles in the Enantioselective Synthesis of β-Amino Acids

ChemInform ◽

10.1002/chin.199746322 ◽

2010 ◽

Vol 28 (46) ◽

pp. no-no

Author(s):

E. JUARISTI ◽

O. GARCIA-BARRADAS

Keyword(s):

Amino Acids ◽

Enantioselective Synthesis ◽

Asymmetric Addition ◽

Unsaturated Esters

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ChemInform Abstract: Catalytic Asymmetric Synthesis of the Docetaxel (Taxotere) Side Chain: Organocatalytic Highly Enantioselective Synthesis of Esterification-Ready α-Hydroxy-β-amino Acids.

ChemInform ◽

10.1002/chin.200909080 ◽

2009 ◽

Vol 40 (9) ◽

Author(s):

Pawel Dziedzic ◽

Jan Vesely ◽

Armando Cordova

Keyword(s):

Amino Acids ◽

Asymmetric Synthesis ◽

Enantioselective Synthesis ◽

Side Chain ◽

Catalytic Asymmetric Synthesis ◽

Catalytic Asymmetric

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Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes.

ChemInform ◽

10.1002/chin.200739059 ◽

2007 ◽

Vol 38 (39) ◽

Author(s):

Xing Dai ◽

Takashi Nakai ◽

Jan A. C. Romero ◽

Gregory C. Fu

Keyword(s):

Enantioselective Synthesis ◽

Hydrazoic Acid ◽

Asymmetric Addition ◽

Catalytic Asymmetric

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ChemInform Abstract: Enantioselective Synthesis of Furyl Alcohols by Catalytic Asymmetric Addition of Diethylzinc to Furanaldehydes.

ChemInform ◽

10.1002/chin.199026175 ◽

1990 ◽

Vol 21 (26) ◽

Author(s):

A. VAN OEVEREN ◽

W. MENGE ◽

B. L. FERINGA

Keyword(s):

Enantioselective Synthesis ◽

Asymmetric Addition ◽

Catalytic Asymmetric

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ChemInform Abstract: Enantioselective Synthesis of sec-Allyl Alcohols by Catalytic Asymmetric Addition of Divinylzinc to Aldehydes.

ChemInform ◽

10.1002/chin.198918155 ◽

1989 ◽

Vol 20 (18) ◽

Author(s):

W. OPPOLZER ◽

R. N. RADINOV

Keyword(s):

Enantioselective Synthesis ◽

Asymmetric Addition ◽

Catalytic Asymmetric ◽

Allyl Alcohols

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Catalytic asymmetric synthesis of the docetaxel (Taxotere) side chain: organocatalytic highly enantioselective synthesis of esterification-ready α-hydroxy-β-amino acids

Tetrahedron Letters ◽

10.1016/j.tetlet.2008.09.038 ◽

2008 ◽

Vol 49 (47) ◽

pp. 6631-6634 ◽

Cited By ~ 36

Author(s):

Pawel Dziedzic ◽

Jan Vesely ◽

Armando Córdova

Keyword(s):

Amino Acids ◽

Asymmetric Synthesis ◽

Enantioselective Synthesis ◽

Side Chain ◽

Catalytic Asymmetric Synthesis ◽

Catalytic Asymmetric

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Simple Derivatives of Natural Amino Acids as Chiral Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes.

ChemInform ◽

10.1002/chin.200526022 ◽

2005 ◽

Vol 36 (26) ◽

Author(s):

Zhi-jian Han ◽

Rui Wang ◽

Yi-feng Zhou ◽

Lei Liu

Keyword(s):

Amino Acids ◽

Chiral Ligands ◽

Asymmetric Addition ◽

Catalytic Asymmetric ◽

Natural Amino Acids ◽

Derivatives Of

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ChemInform Abstract: Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-hydroxyoxindoles.

ChemInform ◽

10.1002/chin.201126122 ◽

2011 ◽

Vol 42 (26) ◽

pp. no-no

Author(s):

Ke Zheng ◽

Chengkai Yin ◽

Xiaohua Liu ◽

Lili Lin ◽

Xiaoming Feng

Keyword(s):

Enantioselective Synthesis ◽

Asymmetric Addition ◽

Dicarbonyl Compounds ◽

Enol Ethers ◽

Catalytic Asymmetric ◽

Alkyl Enol Ethers

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ChemInform Abstract: Enantioselective Synthesis and Use in Catalytic Asymmetric Addition of Diethylzinc to Benzaldehyde of New Chiral Cyclic Hydroxyamino Ferrocene and Chromium Complexes: Influence of the Complexation on the Enantioselectivity.

ChemInform ◽

10.1002/chin.199901039 ◽

2010 ◽

Vol 30 (1) ◽

pp. no-no

Author(s):

S. MALFAIT ◽

L. PELINSKI ◽

J. BROCARD

Keyword(s):

Enantioselective Synthesis ◽

Chromium Complexes ◽

Asymmetric Addition ◽

Catalytic Asymmetric

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