scholarly journals Reductive conjugate addition nitro-Mannich route for the stereoselective synthesis of 1,2,3,4-tetrahydroquinoxalines

2016 ◽  
Vol 14 (35) ◽  
pp. 8270-8277 ◽  
Author(s):  
James C. Anderson ◽  
Ian B. Campbell ◽  
Sebastien Campos ◽  
Iain H. Reid ◽  
Christopher D. Rundell ◽  
...  
Keyword(s):  
Mannich Reaction ◽  
Stereoselective Synthesis ◽  
Conjugate Addition ◽  
High Yield

A reductive conjugate addition nitro-Mannich reaction controls diastereoselectivity in a rapid entry to a diverse array of 1,2,3,4-tetrahydroquinoxalines in high yield.

ChemInform Abstract: Stereoselective Synthesis of 1,2-Diamine Containing Indolines by a Conjugate Addition Nitro-Mannich Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (20) ◽  
pp. no-no
Author(s):  
James C. Anderson ◽  
Ian B. Campbell ◽  
Sebastien Campos ◽  
Jonathan Shannon ◽  
Derek A. Tocher
Keyword(s):  
Mannich Reaction ◽  
Stereoselective Synthesis ◽  
Conjugate Addition

scholarly journals Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-mannich reaction

2015 ◽  
Vol 13 (1) ◽  
pp. 170-177 ◽  
Author(s):  
James C. Anderson ◽  
Ian B. Campbell ◽  
Sebastien Campos ◽  
Jonathan Shannon ◽  
Derek A. Tocher
Keyword(s):  
Mannich Reaction ◽  
Stereoselective Synthesis ◽  
Conjugate Addition ◽  
Nitro Reduction

The sequential use of the conjugate addition nitro-Mannich reaction, nitro reduction and then Pd-catalyzed intramolecular cyclisation allows the concise, stereodivergent synthesis of complex indolines.

Diastereoselective Synthesis of γ-Lactams and δ-Lactams via a Conjugate Addition-Initiated Tandem Reaction

Synlett ◽  
2019 ◽  
Vol 30 (12) ◽  
pp. 1447-1451
Author(s):  
Miaomiao Gan ◽  
Lan Jiang ◽  
Zhengning Li
Keyword(s):  
Mannich Reaction ◽  
Conjugate Addition ◽  
High Yield ◽  
Tandem Reaction ◽  
Diastereoselective Synthesis ◽  
Diethyl Zinc ◽  
Ready Availability

β-Alkoxycarbonyl-γ-lactams and γ-alkoxycarbonyl-δ-lactams were synthesized via a conjugate alkylation/Mannich reaction/lactamization tandem reaction of unsaturated dicarboxylates with diethyl zinc and aldimines. The high yield, the ready availability of the reagents, and especially the high diastereoselectivity are promising characteristics of the approach that allows access to functionalized lactams.

scholarly journals Rh-Catalyzed Conjugate Addition of Aryl and Alkenyl Boronic Acids to α-Methylene-β-lactones: Stereoselective Synthesis of trans-3,4-Disubstituted β-Lactones

2017 ◽  
Vol 19 (17) ◽  
pp. 4460-4463 ◽  
Author(s):  
Christian A. Malapit ◽  
Irungu K. Luvaga ◽  
Donald R. Caldwell ◽  
Nicholas K. Schipper ◽  
Amy R. Howell
Keyword(s):  
Stereoselective Synthesis ◽  
Conjugate Addition ◽  
Boronic Acids

Formal [4 + 1]- and [5 + 1]-Annulation by an SN2–Conjugate Addition Sequence: Stereoselective Synthesis of Highly Substituted Carbocyles

2013 ◽  
Vol 15 (23) ◽  
pp. 6111-6112 ◽  
Author(s):  
Benny Meng Kiat Tong ◽  
Hui Chen ◽  
Sin Yee Chong ◽  
Yi Li Heng ◽  
Shunsuke Chiba
Keyword(s):  
Stereoselective Synthesis ◽  
Conjugate Addition
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