scholarly journals 5-Bromo-2′-deoxycytidine—a potential DNA photosensitizer

2016 ◽  
Vol 14 (39) ◽  
pp. 9312-9321 ◽  
Author(s):  
Magdalena Zdrowowicz ◽  
Paweł Wityk ◽  
Barbara Michalska ◽  
Janusz Rak
Keyword(s):  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Cross Links

Photoinduced single strand breaks and intrastrand cross-links are formed in an oligonucleotide labeled with 5-bromo-2′-deoxycytidine.

Photoinduced Single Strand Breaks and Intrastrand Cross-Links in an Oligonucleotide Labeled with 5-Bromouracil

2014 ◽  
Vol 118 (19) ◽  
pp. 5009-5016 ◽  
Author(s):  
Magdalena Zdrowowicz ◽  
Barbara Michalska ◽  
Agnieszka Zylicz-Stachula ◽  
Janusz Rak
Keyword(s):  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Cross Links

scholarly journals The integrity of deoxyribonucleic acid extracted from Escherichia coli 15T- after thymine-less death

1965 ◽  
Vol 97 (1) ◽  
pp. 240-246 ◽  
Author(s):  
BJ Smith ◽  
K Burton
Keyword(s):  
Escherichia Coli ◽  
Deoxyribonucleic Acid ◽  
Coli Strain ◽  
Single Strand ◽  
Aqueous Alkali ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Cross Links ◽  
Integrity Of Dna

1. The integrity of DNA extracted from Escherichia coli strain 15T(-) after thymine-less death was examined by studying the effects of treatment with aqueous alkali on the solubility in dilute acids and by viscosity and ultracentrifugal measurements, some of which were designed to detect single-strand breaks or inter-strand cross-links. None of the results showed that there was any modification or damage associated with thymine-less death.

Bromodeoxyuridine: a comparison of its photosensitizing and radiosensitizing properties

1988 ◽  
Vol 69 (3) ◽  
pp. 410-415 ◽  
Author(s):  
Corey Raffel ◽  
Dennis F. Deen ◽  
Michael S. B. Edwards
Keyword(s):  
Uv Light ◽  
Tumor Cell Line ◽  
Single Strand ◽  
Enhancement Ratio ◽  
Dose Enhancement ◽  
Content Type ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Cross Links

✓ The photo- and radiosensitizing properties of bromodeoxyuridine (BUdR) were assessed in vitro using the 9L rat brain tumor cell line. Pretreatment of 9L cells with 10 µM BUdR for 24 hours followed by irradiation with ultraviolet (UV) light resulted in a dose-enhancement ratio of 3.8:1 compared with UV radiation alone. X-radiation of BUdR-pretreated cells produced a dose-enhancement ratio of 1.7:1. Alkaline elution analysis of deoxyribonucleic acid (DNA) from cells treated with BUdR and UV irradiation showed the presence of DNA single-strand breaks and DNA-protein cross-links. Analysis of DNA from cells treated with BUdR and then x-irradiated showed no increase in DNA single-strand breaks compared with cells treated with x-radiation alone; no DNA-protein cross-links could be detected. The possible clinical relevance of these findings is discussed.

Inter-strand cross-links and single-strand breaks produced by gold(I) and gold(III) coordination complexes

1986 ◽  
Vol 35 (9) ◽  
pp. 1435-1443 ◽  
Author(s):  
Christopher K. Mirabelli ◽  
Joseph P. Zimmerman ◽  
Henry R. Bartus ◽  
Sung Chiu-Mei ◽  
Stanley T. Crooke
Keyword(s):  
Coordination Complexes ◽  
Single Strand ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Cross Links
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