Identification of novel small-molecule inhibitors targeting menin–MLL interaction, repurposing the antidiarrheal loperamide

2016 ◽  
Vol 14 (36) ◽  
pp. 8503-8519 ◽  
Author(s):  
Liyan Yue ◽  
Juanjuan Du ◽  
Fei Ye ◽  
Zhifeng Chen ◽  
Lianchun Li ◽  
...  
Keyword(s):  
Small Molecule ◽  
Medicinal Chemistry ◽  
Small Molecule Inhibitors ◽  
Scaffold Hopping ◽  
Biochemical Studies

Scaffold hopping combines with biochemical studies and medicinal chemistry optimizations, leading to potent inhibitors of the menin–MLL interaction.

Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping

2012 ◽  
Vol 55 (14) ◽  
pp. 6278-6293 ◽  
Author(s):  
Jing Deng ◽  
Ning Li ◽  
Hongchuan Liu ◽  
Zhili Zuo ◽  
Oi Wah Liew ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Scaffold Hopping ◽  
Ns3 Protease

scholarly journals Non-substrate based, small molecule inhibitors of the human isoprenylcysteine carboxyl methyltransferase

MedChemComm ◽  
2016 ◽  
Vol 7 (5) ◽  
pp. 1016-1021 ◽  
Author(s):  
Kyle V. Butler ◽  
Kelsey Bohn ◽  
Christine A. Hrycyna ◽  
Jian Jin
Keyword(s):  
Small Molecule ◽  
Medicinal Chemistry ◽  
Small Molecule Inhibitors ◽  
Carboxyl Methyltransferase ◽  
Isoprenylcysteine Carboxyl Methyltransferase

Screening and subsequent medicinal chemistry gave a new chemotype for hICMT inhibitors.

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