Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines

2016 ◽  
Vol 14 (30) ◽  
pp. 7226-7237 ◽  
Author(s):  
An Xiao ◽  
Xiu-Jing Zheng ◽  
Chengcheng Song ◽  
Yue Gui ◽  
Chang-Xin Huo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Tandem Repeat ◽  
Repeat Sequence ◽  
Tandem Repeat Sequence ◽  
Protein Conjugates ◽  
Anticancer Vaccines ◽  
Immunological Evaluation ◽  
High Immunogenicity

Unnatural STn disaccharides with N-acetyl modifications were incorporated into a 20-amino acid MUC1 tandem repeat sequence. The modified STn-MUC1 glycopeptide–protein conjugates showed high immunogenicity.

Synthesis of MUC1 Peptide and Glycopeptide Dendrimers

2009 ◽  
Vol 62 (10) ◽  
pp. 1339 ◽  
Author(s):  
Candy K. Y. Chun ◽  
Richard J. Payne
Keyword(s):  
Peptide Synthesis ◽  
Tandem Repeat ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Cycloaddition Reaction ◽  
Repeat Sequence ◽  
Tandem Repeat Sequence ◽  
Multiple Copies ◽  
Fmoc Strategy

Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.

scholarly journals New Tools for Hop Cytogenomics: Identification of Tandem Repeat Families from Long-Read Sequences of Humulus lupulus

2020 ◽  
Author(s):  
Katherine A. Easterling ◽  
Nicholi J. Pitra ◽  
Taylan B. Morcol ◽  
Jenna R. Aquino ◽  
Lauren G. Lopes ◽  
...  
Keyword(s):  
Tandem Repeat ◽  
Mendelian Inheritance ◽  
Repeat Sequence ◽  
Humulus Lupulus ◽  
Comparative Genomic ◽  
Dioecious Species ◽  
Tandem Repeat Sequence ◽  
Genome Maps ◽  
Meiotic Chromosomes ◽  
Long Read

ABSTRACTHop (Humulus lupulus L.) is known for its use as a bittering agent in beer and has a rich history of cultivation, beginning in Europe and now spanning the globe. There are five wild varieties worldwide, which may have been introgressed with cultivated varieties. As a dioecious species, its obligate outcrossing, non-Mendelian inheritance, and genomic structural variability have confounded directed breeding efforts. Consequently, understanding genome evolution in Humulus represents a considerable challenge, requiring additional resources, including integrated genome maps. In order to facilitate cytogenetic investigations into the transmission genetics of hop, we report here the identification and characterization of 17 new and distinct tandem repeat sequence families. A tandem repeat discovery pipeline was developed using k-mer filtering and dot plot analysis of PacBio long-read sequences from the hop cultivar Apollo. We produced oligonucleotide FISH probes from conserved regions of HuluTR120 and HulTR225 and demonstrated their utility to stain meiotic chromosomes from wild hop, var. neomexicanus. The HuluTR225 FISH probe hybridized to several loci per nucleus and exhibited irregular, non-Mendelian transmission in male meiocytes of wild hop. Collectively, these tandem repeat sequence families not only represent unique and valuable new cytogenetic reagents but also have the capacity to inform genome assembly efforts and support comparative genomic analyses.

An extra insertion of tandem repeat sequence in African swine fever virus, China, 2019

Virus Genes ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 843-847 ◽  
Author(s):  
Shengqiang Ge ◽  
Yutian Liu ◽  
Lin Li ◽  
Qinghua Wang ◽  
Jinming Li ◽  
...  
Keyword(s):  
Tandem Repeat ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Repeat Sequence ◽  
Fever Virus ◽  
Tandem Repeat Sequence

Study on Tandem Repeat Sequence Variation in Sheep mtDNA D-loop Region

2006 ◽  
Vol 33 (12) ◽  
pp. 1087-1095 ◽  
Author(s):  
LI Xiang-Long ◽  
GONG Yuan-Fang ◽  
LIU Zheng-Zhu ◽  
ZHENG Gui-Ru ◽  
ZHOU Rong-Yan ◽  
...  
Keyword(s):  
Tandem Repeat ◽  
Sequence Variation ◽  
Repeat Sequence ◽  
Tandem Repeat Sequence ◽  
Loop Region ◽  
D Loop
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