Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion

2016 ◽  
Vol 14 (32) ◽  
pp. 7676-7690 ◽  
Author(s):  
Chenzhou Hao ◽  
Xiaodong Li ◽  
Shuai Song ◽  
Bingyu Guo ◽  
Jing Guo ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Natural Product ◽  
Tumor Cell Growth ◽  
New Class ◽  
Anti Cancer

Discovery of a new class of natural product-inspired PAK4 inhibitors as potent anti-cancer agents.

In situ condensation of an anti-cancer drug into fibrin gel enabling effective inhibition of tumor cell growth

2019 ◽  
Vol 55 (78) ◽  
pp. 11679-11682 ◽  
Author(s):  
Masayasu Kuwahara ◽  
Hiroto Fujita ◽  
Yuka Kataoka ◽  
Yasuyo Nakajima ◽  
Masanobu Yamada ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cancer Drug ◽  
Tumor Cell Growth ◽  
Fibrin Gel ◽  
Anti Cancer ◽  
Effective Inhibition

Efficient anti-cancer drug condensation enabled equally inhibiting cell proliferation even at a concentration of 7.6 ± 0.36 nM, which was approximately 170-fold lower than the standard therapeutic concentrations of camptothecin (CPT) drugs.

scholarly journals Extract Derived from Cedrus atlantica Acts as an Antitumor Agent on Hepatocellular Carcinoma Growth In Vitro and In Vivo

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4608 ◽  
Author(s):  
Xiao-Fan Huang ◽  
Kai-Fu Chang ◽  
Shan-Chih Lee ◽  
Gwo-Tarng Sheu ◽  
Chia-Yu Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Tumor Cell ◽  
Dependent Manner ◽  
Tumor Cell Growth ◽  
Normal Cells ◽  
Cedrus Atlantica ◽  
Anti Cancer

Cedrus atlantica is widely used in herbal medicine. However, the anti-cancer activity of C. atlantica extract (CAt extract) has not been clarified in hepatocellular carcinoma. In the study, we elucidated the anti-hepatoma capacity of CAt extract on HCC in vitro and in vivo. To explore the anti-hepatoma mechanisms of the CAt extract in vitro, HCC and normal cells were treated with the CAt extract, which showed marked inhibitory effects on HCC cells in a dose-dependent manner; in contrast, the CAt extract treatment was less cytotoxic to normal cells. In addition, our results indicate that the CAt extract induced apoptosis via caspase-dependent and independent apoptosis pathways. Furthermore, the CAt extract inhibited HCC tumor cell growth by restraining cell cycle progression, and it reduced the signaling of the AKT, ERK1/2, and p38 pathways. In the xenograft model, the CAt extract suppressed HCC tumor cell growth and prolonged lifespan by inhibiting PCNA protein expression, repressing part of the VEGF-induced autocrine pathway, and triggering strong expression of cleaved caspase-3, which contributed to cell apoptosis. Moreover, the CAt extract did not induce any obvious changes in pathological morphology or body weight, suggesting it had no toxicity. CAt extract exerted anti-tumor effects on HCC in vitro and in vivo. Thus, CAt extract could be used as a potential anti-cancer therapeutic agent against HCC.

Grifolin, a potential antitumor natural product from the mushroomAlbatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro

FEBS Letters ◽  
2005 ◽  
Vol 579 (16) ◽  
pp. 3437-3443 ◽  
Author(s):  
Mao Ye ◽  
Ji-kai Liu ◽  
Zhong-xin Lu ◽  
Yan Zhao ◽  
Su-fang Liu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Natural Product ◽  
Tumor Cell Growth ◽  
Potential Antitumor

scholarly journals Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

1995 ◽  
Vol 36 (3) ◽  
pp. 611-621
Author(s):  
A Abe ◽  
N S Radin ◽  
J A Shayman ◽  
L L Wotring ◽  
R E Zipkin ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cell Growth ◽  
Glucosylceramide Synthase

Bcl-2 targeting siRNA expressed by a T7 vector system inhibits human tumor cell growth in vitro

2004 ◽  
Author(s):  
Lori Holle ◽  
Labri Hicks ◽  
Wendy Song ◽  
Eric Holle ◽  
Thomas Wagner ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Human Tumor ◽  
Vector System ◽  
Tumor Cell Growth ◽  
Human Tumor Cell

scholarly journals Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo

Oncogene ◽  
2000 ◽  
Vol 19 (4) ◽  
pp. 505-513 ◽  
Author(s):  
V A Krutovskikh ◽  
S M Troyanovsky ◽  
C Piccoli ◽  
H Tsuda ◽  
M Asamoto ◽  
...  
Keyword(s):  
Cell Growth ◽  
Subcellular Localization ◽  
Tumor Cell ◽  
Gap Junction ◽  
Differential Effect ◽  
Tumor Cell Growth ◽  
Junction Protein ◽  
Gap Junction Protein

IL2/IL-4, OX40L and FDC-like cell line support the in vitro tumor cell growth of adult T-cell leukemia/lymphoma

2014 ◽  
Vol 38 (5) ◽  
pp. 608-612 ◽  
Author(s):  
Dai Chihara ◽  
Yoshitoyo Kagami ◽  
Harumi Kato ◽  
Noriaki Yoshida ◽  
Tohru Kiyono ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Growth ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia
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