Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid

2016 ◽  
Vol 14 (20) ◽  
pp. 4571-4575 ◽  
Author(s):  
Tao Chen ◽  
Ying-Yeung Yeung
Keyword(s):  
Carboxylic Acid ◽  
Trifluoroacetic Acid ◽  
Acid Catalyzed

A trifluoroacetic acid catalyzed highly 6-endo regioselective bromocyclization of styrene-type carboxylic acid has been developed.

THE PRINS REACTION WITH β,γ-UNSATURATED ACIDS AND AMIDES

1957 ◽  
Vol 35 (7) ◽  
pp. 673-676 ◽  
Author(s):  
B. Belleau
Keyword(s):  
Trifluoroacetic Acid ◽  
Prins Reaction ◽  
Acid Catalyzed

The acid catalyzed condensation of cyclohexenylacetic acid and its corresponding N-methylamide with formaldehyde was investigated. Good yields of the expected δ-lactone (V) or δ-lactam (IX) were obtained when trifluoroacetic acid was used both as catalyst and solvent for the reaction.

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