scholarly journals Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

2016 ◽  
Vol 14 (11) ◽  
pp. 3120-3129 ◽  
Author(s):  
Stephen Thompson ◽  
Ian N. Fleming ◽  
David O'Hagan
Keyword(s):  
Positron Emission Tomography ◽  
Rgd Peptide ◽  
Emission Tomography ◽  
Ambient Conditions ◽  
Positron Emission

The fluorinase enzyme is used to catalyse transhalogenation reactions on dendritic RGD peptide constructs. The strategy is explored for [18F]-radiolabelling of peptides under neutral aqueous ambient conditions for positron emission tomography (PET).

scholarly journals A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

2015 ◽  
Vol 51 (70) ◽  
pp. 13542-13545 ◽  
Author(s):  
S. Thompson ◽  
M. Onega ◽  
S. Ashworth ◽  
I. N. Fleming ◽  
J. Passchier ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Click Reaction ◽  
Rgd Peptide ◽  
Emission Tomography ◽  
Positron Emission ◽  
Water Ph ◽  
18F Labelling

Fluorine-18 radiolabelling of a peptide is conducted in water (pH 7.8 and 37 °C) using the fluorinase enzyme and a ‘click’ reaction.

Positron Emission Tomography of Cocaine Binding Sites on the Dopamine Transporter

1994 ◽  
Author(s):  
Bertha K. Madras ◽  
◽  
David R. Elmaleh ◽  
Peter C. Meltzer ◽  
Anna Y. Liung ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Transporter ◽  
Binding Sites ◽  
Emission Tomography ◽  
Positron Emission
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