scholarly journals Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin

Nanoscale ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 3941-3951 ◽  
Author(s):  
Cristina Cantarutti ◽  
Sara Raimondi ◽  
Giorgia Brancolini ◽  
Alessandra Corazza ◽  
Sofia Giorgetti ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Β2 Microglobulin ◽  
Pathological Variant

scholarly journals Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and ΔN6 β2-microglobulin variants

Nanoscale ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 4793-4806 ◽  
Author(s):  
Giorgia Brancolini ◽  
Maria Celeste Maschio ◽  
Cristina Cantarutti ◽  
Alessandra Corazza ◽  
Federico Fogolari ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Protein Aggregation ◽  
Amyloid Fibril ◽  
Fibril Formation ◽  
Β2 Microglobulin ◽  
Amyloid Fibril Formation

Mechanism for how citrate covered gold NP influence protein aggregation and thus fibril formation for the highly amyloidogenic variants D76N and ΔN6 β2-microglobulin.

scholarly journals The interaction of β2-microglobulin with gold nanoparticles: impact of coating, charge and size

2018 ◽  
Vol 6 (37) ◽  
pp. 5964-5974 ◽  
Author(s):  
Cristina Cantarutti ◽  
Paolo Bertoncin ◽  
Paola Posocco ◽  
Yamanappa Hunashal ◽  
Sofia Giorgetti ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Β2 Microglobulin

Gold nanoparticles (AuNPs) have been proved to be ideal scaffolds to build nanodevices whose performance can be tuned by changing their coating.

scholarly journals Can small hydrophobic gold nanoparticles inhibit β2-microglobulin fibrillation?

Nanoscale ◽  
2014 ◽  
Vol 6 (14) ◽  
pp. 7903-7911 ◽  
Author(s):  
Giorgia Brancolini ◽  
Dimitrios Toroz ◽  
Stefano Corni
Keyword(s):  
Molecular Dynamics ◽  
Gold Nanoparticles ◽  
Molecular Dynamics Simulations ◽  
Β2 Microglobulin ◽  
Dynamics Simulations ◽  
Small Hydrophobic

Molecular dynamics simulations suggest that small hydrophobic gold nanoparticles can stabilize the native folding of the β2-microglobulin protein.

scholarly journals Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

2018 ◽  
Vol 54 (43) ◽  
pp. 5422-5425 ◽  
Author(s):  
Cristina Cantarutti ◽  
Gijo Raj ◽  
Federico Fogolari ◽  
Sofia Giorgetti ◽  
Alessandra Corazza ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Β2 Microglobulin ◽  
Association Equilibria

Citrate-coated gold nanoparticles interfere with the association equilibria of β2-microglobulin and thus inhibit the early events of fibrillogenesis.

A NMR study of human β2 microglobulin

1981 ◽  
Vol 78 ◽  
pp. 837-841 ◽  
Author(s):  
Marcel Sarrazin ◽  
Claudette Briand ◽  
Madeleine Bourdeaux ◽  
Michèle Chauvet ◽  
Claude Vincent ◽  
...  
Keyword(s):  
Β2 Microglobulin ◽  
Nmr Study

EpCam-specific Gold Nanoparticles for Detection, Live-imaging and Rapid Enrichment of Adult Human Liver Progenitor Cells

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
N Fekete-Drimusz ◽  
J de la Roche ◽  
F Vondran ◽  
CL Sajti ◽  
MP Manns ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Progenitor Cells ◽  
Human Liver ◽  
Live Imaging ◽  
Adult Human

Urinary Beta-Thromboglobulin Correlates with Impairment of Renal Function in Patients with Diabetic Nephropathy

1986 ◽  
Vol 56 (02) ◽  
pp. 229-231 ◽  
Author(s):  
A H Hopper ◽  
H Tindall ◽  
J A Davies
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Microvascular Disease ◽  
Normal Subjects ◽  
Specific Protein ◽  
Creatinine Concentration ◽  
Β2 Microglobulin ◽  
Plasma Creatinine Concentration ◽  
Insulin Dependent ◽  
Indium 111

SummaryTBeta-thromboglobulin (βTG) is a platelet-specific protein and since its concentration in plasma rises when platelets are activated, it has been used as an indicator of platelet involvement in vascular disease. Since platelets might be involved in the pathogenesis of diabetic microvascular disease we measured urinary βTG in 20 insulin-dependent diabetics with nephropathy and compared the results with those from 20 normal subjects. Measurement of βTG in urine was undertaken to avoid errors induced by blood sampling and to gain information over a prolonged period using a single assay. Measurements were made of βTG, β2-microglobulin and total protein in urine collected for 24 h and creatinine and β2 microglobulin in plasma. Survival of indium-111-labelled platelets was measured in nine patients. Urinary PTG was significantly (p <0.02) increased in the 20 patients compared with 20 normal volunteers (median value 1.3 vs 0.8 μg/24 h). There was a strong correlation between urinary βTG excretion and plasma creatinine concentration (r = 0.8, p <0.0001) and plasma β2-microglobulin concentration (r = 0.9, p <0.0001). Urinary βTG concentration did not correlate with platelet survival. The results indicate that although urinary βTG is significantly increased in patients with diabetic nephropathy its concentration in urine correlates with indicators of glomerular filtration rather than with a test of platelet activation.

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