Dual antibacterial activities of a chitosan-modified upconversion photodynamic therapy system against drug-resistant bacteria in deep tissue

Nanoscale ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 3912-3924 ◽  
Author(s):  
Siwen Li ◽  
Sisi Cui ◽  
Deyan Yin ◽  
Qiuyun Zhu ◽  
Yuxiang Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antibacterial Activities ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Deep Tissue ◽  
Drug Resistant Bacteria

scholarly journals Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rui Wang ◽  
Miusi Shi ◽  
Feiyan Xu ◽  
Yun Qiu ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Antibacterial Activities ◽  
Titanium Implants ◽  
Bone Tissue Regeneration ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Implant Infection ◽  
Tio2 Nanofibers ◽  
Antibacterial Ability ◽  
Drug Resistant Bacteria

Abstract Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.

The antibacterial activities of MoS2 nanosheets towards multi-drug resistant bacteria

2021 ◽  
Vol 57 (24) ◽  
pp. 2998-3001
Author(s):  
Yingcan Zhao ◽  
Yuexiao Jia ◽  
Jiayi Xu ◽  
Liang Han ◽  
Feng He ◽  
...  
Keyword(s):  
Molybdenum Disulfide ◽  
Antibacterial Activities ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Mos2 Nanosheets ◽  
Solar Disinfection ◽  
Drug Resistant Bacteria

We demonstrated that molybdenum disulfide (MoS2) nanosheets can be an excellent solar disinfection agent for multi-drug resistant (MDR) bacteria with disinfection efficiencies >99.9999% in only 30 min.

scholarly journals AIE-Active Poly(phenyleneethynylene)s for Fluorescence and Raman Dual-Modal Imaging and Drug-Resistant Bacteria Killing

2021 ◽  
Author(s):  
xiang su ◽  
ruihua liu ◽  
Ying Li ◽  
Ting Han ◽  
Zhijun Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Mammalian Cells ◽  
Antibacterial Activities ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Organic Optoelectronics ◽  
Drug Resistant Bacteria ◽  
Fluorescence Efficiency ◽  
Alkyl Side Chains ◽  
Bacteria Killing

Poly(phenyleneethynylene) (PPE) is a widely used functional conjugated polymer with applications ranging from organic optoelectronics and fluorescence sensors to optical imaging and theranostics. However, the fluorescence efficiency of PPE in aggregate states is generally not as good as their solution states, which greatly compromises their performance in fluorescence-related applications. Herein, we design and synthesize a series of PPE derivatives with typical aggregation-induced emission (AIE) properties. In these PPEs, the diethylamino-substituted tetraphenylethene units function as the long-wavelength AIE source and the alkyl side chains serve as the functionalization site. The obtained AIE-active PPEs with large π-conjugation show strong aggregate-state fluorescence, interesting self-assembly behaviors, inherently enhanced alkyne vibrations in the Raman-silent region of cells, and efficient antibacterial activities. The PPE nanoparticles with good cellular uptake capability can clearly and sensitively visualize the tumor region and residual tumors via their fluorescence and Raman signals, respectively, to benefit the precise tumor surgery. After post-functionalization, the obtained PPE-based polyelectrolyte can preferentially image bacteria over mammalian cells and possesses efficient photodynamic killing capability against Gram-positive and drug-resistant bacteria. This work provides a feasible design strategy for developing multifunctional conjugated polymers with multimodal imaging capability as well as photodynamic antimicrobial ability.

High antimicrobial photodynamic activity of photosensitizer encapsulated dual-functional metallocatanionic vesicles against drug-resistant bacteria S. aureus

2020 ◽  
Vol 8 (10) ◽  
pp. 2905-2920 ◽  
Author(s):  
Bunty Sharma ◽  
Gurpreet Kaur ◽  
Ganga Ram Chaudhary ◽  
Santosh L. Gawali ◽  
P. A. Hassan
Keyword(s):  
Photodynamic Therapy ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Penetration Effect ◽  
Dual Functional ◽  
Drug Resistant Bacteria ◽  
Photodynamic Activity ◽  
Effect Of Light

Developments in the field of photodynamic therapy (PDT) are being made by investigating appropriate photosensitizers (PSs) and enhancing the penetration effect of light by developing new metallocatanionic vesicles.

scholarly journals Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

2021 ◽  
Vol 22 (12) ◽  
pp. 6392
Author(s):  
Nikita Suvorov ◽  
Viktor Pogorilyy ◽  
Ekaterina Diachkova ◽  
Yuri Vasil’ev ◽  
Andrey Mironov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Heterocyclic Compounds ◽  
Resistant Bacteria ◽  
Antimicrobial Photodynamic Therapy ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Major Research ◽  
Drug Resistant Bacteria ◽  
Research Challenge ◽  
Derivatives Of

The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.

scholarly journals Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 964
Author(s):  
Noor Akbar ◽  
Jasra Gul ◽  
Ruqaiyyah Siddiqui ◽  
Muhammad Raza Shah ◽  
Naveed Ahmed Khan
Keyword(s):  
Antibacterial Activities ◽  
Human Cells ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Force Microscopy ◽  
Human Red Blood Cells ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant ◽  
Approved Drugs

Antibiotic resistance is a major concern given the rapid emergence of multiple-drug-resistant bacteria compared to the discovery of novel antibacterials. An alternative strategy is enhancing the existing available drugs. Nanomedicine has emerged as an exciting area of research, showing promise in the enhanced development of existing antimicrobials. Herein, we synthesized nanocarriers and loaded these with available clinically approved drugs, namely Moxifloxacin and Sulfamethoxazole. Bactericidal activity against Gram-negative (Serratia marcescens, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella enterica) and Gram-positive (methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Bacillus cereus) bacteria was investigated. To characterize the nanocarriers and their drug-loaded forms, Fourier-transform infrared spectroscopy, dynamic light scattering, and atomic force microscopy were utilized. Antibacterial assays and hemolysis assays were carried out. Moreover, lactate dehydrogenase assays were performed to determine cytotoxicity against human cells. The results depicted the successful formation of drug–nanocarrier complexes. The potent antibacterial activities of the drug-loaded nanocarriers were observed and were significantly enhanced in comparison to the drugs alone. Hemolysis and cytotoxicity assays revealed minimal or negligible cytotoxic effects against human red blood cells and human cells. Overall, metronidazole-based nanocarriers loaded with Moxifloxacin and Sulfamethoxazole showed enhanced bactericidal effects against multiple-drug-resistant bacteria compared with drugs alone, without affecting human cells. Our findings show that drug-loaded nanocarriers hold promise as potent chemotherapeutic drugs against multiple-drug-resistant bacteria.

scholarly journals GC-MS Analysis and Antibacterial Effects of Vernonia glaberrima n-Hexane Extracts alone and in Combination with Standard Antibiotics

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
P. Gangas ◽  
A.B. Aliyu ◽  
A.O. Oyewale
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Activities ◽  
Fatty Acid Esters ◽  
Gas Chromatography Mass Spectrometry ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Ms Analysis ◽  
Drug Resistant Bacteria ◽  
Hexane Extracts

The occurrence of drug resistant bacteria warrant investigation on herbal plants for effective antibacterial agents. Vernonia glaberrima leaf (VGL) and stem (VGS) hexane extracts were subjected to analysis by gas chromatography-mass spectrometry (GC-MS) and subsequently evaluated for antibacterial activity alone and in combination each with Sparfloxacin (SPX) and Ciprofloxacin (CPX) on selected bacteria including resistant species. GC-MS analysis revealed fatty acid esters, triterpenoids and aromatic derivatives largely identified as responsible for the broad-spectrum antibacterial activity. Both the VGL and VGS demonstrated potent antibacterial activities on P. aeruginosa (29 mm and 27 mm), respectively. However, combination of SPX with VGL potentiated the effects on E. coli and S. typhi by synergistic interaction. Similarly, the efficacy of CFX in combination with VGS on MRSA (30 mm) was significantly enhanced by additive action. It was observed that VGS potentiation of CFX on P. aeruginosa (32 mm) was the most effective antibacterial inhibition recorded in the study. Thus, combination of SPX and CFX each with the extracts has revealed remarkable properties for alternative or complementary therapeutic strategy. Our findings elicit enormous potentials of V. glaberrima hexane extracts as treatment adjuncts for combating drug resistant bacteria. It will be interesting to evaluate in vivo effects of extracts in combination with antibiotics against drug resistant bacteria.

scholarly journals AIE-Active Poly(phenyleneethynylene)s for Fluorescence and Raman Dual-Modal Imaging and Drug-Resistant Bacteria Killing

2021 ◽  
Author(s):  
xiang su ◽  
ruihua liu ◽  
Ying Li ◽  
Ting Han ◽  
Zhijun Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Mammalian Cells ◽  
Antibacterial Activities ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Organic Optoelectronics ◽  
Drug Resistant Bacteria ◽  
Fluorescence Efficiency ◽  
Alkyl Side Chains ◽  
Bacteria Killing

Poly(phenyleneethynylene) (PPE) is a widely used functional conjugated polymer with applications ranging from organic optoelectronics and fluorescence sensors to optical imaging and theranostics. However, the fluorescence efficiency of PPE in aggregate states is generally not as good as their solution states, which greatly compromises their performance in fluorescence-related applications. Herein, we design and synthesize a series of PPE derivatives with typical aggregation-induced emission (AIE) properties. In these PPEs, the diethylamino-substituted tetraphenylethene units function as the long-wavelength AIE source and the alkyl side chains serve as the functionalization site. The obtained AIE-active PPEs with large π-conjugation show strong aggregate-state fluorescence, interesting self-assembly behaviors, inherently enhanced alkyne vibrations in the Raman-silent region of cells, and efficient antibacterial activities. The PPE nanoparticles with good cellular uptake capability can clearly and sensitively visualize the tumor region and residual tumors via their fluorescence and Raman signals, respectively, to benefit the precise tumor surgery. After post-functionalization, the obtained PPE-based polyelectrolyte can preferentially image bacteria over mammalian cells and possesses efficient photodynamic killing capability against Gram-positive and drug-resistant bacteria. This work provides a feasible design strategy for developing multifunctional conjugated polymers with multimodal imaging capability as well as photodynamic antimicrobial ability.

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