Bio-inspired fabrication and potential applications of hierarchically porous CaCO3 hollow nanospheres

2016 ◽  
Vol 40 (8) ◽  
pp. 6874-6880 ◽  
Author(s):  
Xiaoming Ma ◽  
Yucong Zhu ◽  
Ping Yang ◽  
Zipeng Wei ◽  
Peng Liu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Drug ◽  
Ph Sensitive ◽  
Hollow Nanospheres ◽  
Delivery Vehicle ◽  
Hierarchically Porous ◽  
Potential Applications

Hierarchically porous CaCO3 hollow nanospheres are developed as an efficient pH-sensitive and sustained release anticancer drug (DOX) delivery vehicle.

scholarly journals A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yan Hu ◽  
Sheng Hu ◽  
Shangwen Zhang ◽  
Siyi Dong ◽  
Jie Hu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Double Layer ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Inner Core ◽  
Synthetic Polymer ◽  
Ph Sensitive ◽  
Sustained Drug Delivery ◽  
Potential Applications ◽  
Sensitive Property

AbstractA new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods.

Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH‐sensitive polymeric micelle

2019 ◽  
Vol 136 (32) ◽  
pp. 47854 ◽  
Author(s):  
Xiaotian Shan ◽  
Jing Mao ◽  
Miaomiao Long ◽  
Kamel S. Ahmed ◽  
Changling Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Polymeric Micelle ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery

scholarly journals The interaction of supramolecular anticancer drug amphiphiles with phospholipid membranes

2021 ◽  
Author(s):  
Phu K. Tang ◽  
Anjela Manandhar ◽  
William Hu ◽  
Myungshim Kang ◽  
Sharon M. Loverde
Keyword(s):  
Drug Delivery ◽  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Anticancer Drug ◽  
Phospholipid Membranes ◽  
Delivery Vehicle ◽  
Membrane Interaction ◽  
Drug Delivery Vehicle ◽  
Probe Drug ◽  
Dynamics Simulations

Molecular dynamics simulations probe drug delivery vehicle-membrane interaction.

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