scholarly journals ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells

MedChemComm ◽  
2017 ◽  
Vol 8 (2) ◽  
pp. 295-319 ◽  
Author(s):  
Cyril Ronco ◽  
Anthony R. Martin ◽  
Luc Demange ◽  
Rachid Benhida
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

A review highlighting on cancer stem cells, with an exhaustive listing and comparison of biological efficacies and pharmacology of the inhibitors of 5 pivotal enzymes of the DNA-damage response.

scholarly journals DNA Damage Response/Repair in Cancer Stem Cells — Potential vs. Controversies

10.5772/61355 ◽  
2015 ◽  
Author(s):  
Maria Louka ◽  
Effrossyni Boutou ◽  
Vasiliki Bakou ◽  
Vassiliki Pappa ◽  
Anastasios Georgoulis ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Replication stress drives constitutive activation of the DNA damage response and consequent radioresistance in glioblastoma cancer stem cells

2018 ◽  
Vol 20 (suppl_1) ◽  
pp. i3-i4
Author(s):  
Ross Carruthers ◽  
Shafiq Ahmed ◽  
Shaliny Ramachandran ◽  
Ester Hammond ◽  
Anthony Chalmers
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Replication Stress ◽  
Constitutive Activation ◽  
Damage Response

Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response

Oncogene ◽  
2019 ◽  
Vol 38 (17) ◽  
pp. 3103-3118 ◽  
Author(s):  
Ayala Gold ◽  
Lital Eini ◽  
Malka Nissim-Rafinia ◽  
Ruth Viner ◽  
Shlomit Ezer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Author correction: Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells

2020 ◽  
Vol 122 (2) ◽  
pp. 301-302
Author(s):  
Yulin Chen ◽  
Dan Li ◽  
Dapeng Wang ◽  
Xuefeng Liu ◽  
Ning Yin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Esophageal Cancer ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Heriberto Abraham Valencia-González ◽  
Graciela Ruíz ◽  
Elizabeth Ortiz-Sánchez ◽  
Alejandro García-Carrancá
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Dna Damage Response ◽  
Tumor Cell Line ◽  
Damage Response ◽  
Sensor Proteins ◽  
Dna Damage Response Pathway

Recently, a subpopulation of tumor cells, called cancer stem cells (CSC), has been characterized, and these have emerged as a major topic in cancer research. CSC are proposed to repair DNA damage more efficiently than the rest of tumor cells, resisting chemotherapy or radiotherapy and causing clinical recurrence and metastasis. We aimed to determine the molecular basis of radioresistance and first compared the response to ionizing radiation (IR) between cancer stem cell-enriched cultures grown as spheres and conventional tumor cell line cultures grown as monolayer, from HeLa and MCF-7 cancer cell lines. To verify that our sphere cultures were enriched in CSC, we evaluated the double staining of CD49f and ALDH activity for HeLa cells by flow cytometry. We then evaluated whether differences could exist in sensor elements in the DNA damage response pathway among these cultures. We found that CSC cultures showed less sensitivity to radiation than conventional tumor cell line cultures. We observed a higher baseline expression of activated response sensor proteins of DNA damage, such as ATM, H2A.X, and PARP1, in untreated CSC cultures. These findings provide the first evidence, to our knowledge, that DNA damage response sensor proteins are present and preferentially activated in CSC, as opposed to the bulk of cells in monolayer cultures. Likewise, they provide the basis for biological differences in response to IR between CSC and other tumor cell populations. Understanding the DNA damage response pathway may provide therapeutic targets to sensitize CSC to cytotoxic therapies to improve current cancer treatments.

scholarly journals DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

2011 ◽  
Vol 8 (1) ◽  
pp. 16-29 ◽  
Author(s):  
Cedric Blanpain ◽  
Mary Mohrin ◽  
Panagiota A. Sotiropoulou ◽  
Emmanuelle Passegué
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Tissue Specific ◽  
Damage Response

Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells

2012 ◽  
Vol 113 (12) ◽  
pp. 3643-3652 ◽  
Author(s):  
Yulin Chen ◽  
Dan Li ◽  
Dapeng Wang ◽  
Xuefeng Liu ◽  
Ning Yin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Esophageal Cancer ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

DNA damage response and resistance of cancer stem cells

2020 ◽  
Vol 474 ◽  
pp. 106-117 ◽  
Author(s):  
Etna Abad ◽  
Dmitry Graifer ◽  
Alex Lyakhovich
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response
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