Membranolytic anticancer peptides

MedChemComm ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 2232-2245 ◽  
Author(s):  
G. Gabernet ◽  
A. T. Müller ◽  
J. A. Hiss ◽  
G. Schneider
Keyword(s):  
Mechanisms Of Action ◽  
Therapeutic Success ◽  
Structure Activity Relationships ◽  
Anticancer Peptides ◽  
Structure Activity

Understanding the structure–activity relationships and mechanisms of action of membranolytic anticancer peptides could help them advance to therapeutic success.

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

2021 ◽  
Vol 21 ◽  
Author(s):  
Kong Zhang ◽  
Tianze Li ◽  
Xijie Shan ◽  
Rongfei Lu ◽  
Shaoyong Zhang ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Anticancer Activity ◽  
Structural Modification ◽  
Biological Properties ◽  
Mechanisms Of Action ◽  
Inflammatory Activity ◽  
Anti Psychotic ◽  
Structure Activity Relationships ◽  
Structure Activity

: Cholesterol, a steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 were summarized. In addition, the bioactivities, mechanisms of action and structure-activity relationships of cholesterol and its related derivatives were involved.

scholarly journals Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

Planta Medica ◽  
2020 ◽  
Vol 86 (09) ◽  
pp. 585-618
Author(s):  
Lucia Mamede ◽  
Allison Ledoux ◽  
Olivia Jansen ◽  
Michel Frédérich
Keyword(s):  
Phenolic Compounds ◽  
Traditional Medicine ◽  
Phenolic Acids ◽  
Mechanisms Of Action ◽  
Parasitic Disease ◽  
Structure Activity Relationships ◽  
Antimalarial Agents ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Natural Phenolic Compounds

AbstractMalaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for the search of new antiplasmodial and antimalarial molecules. However, this search for new antimalarials is complex and time-consuming and ultimately leads to a great number of interesting compounds with a lack of discussion of their characteristics. This review aims to examine the most promising antiplasmodial phenolic compounds (phenolic acids, flavonoids, xanthones, coumarins, lignans, among others) and derivatives isolated over the course of the last 28 y (1990 – 2018) and discuss their structure-activity relationships, mechanisms of action, toxicity, new perspectives they could add to the fight against malaria, and finally, the difficulties of transforming these potential compounds into new antimalarials.

Antibacterial green tea catechins from a molecular perspective: mechanisms of action and structure–activity relationships

2020 ◽  
Vol 11 (11) ◽  
pp. 9370-9396
Author(s):  
Andrea Renzetti ◽  
Jonathan W. Betts ◽  
Kozo Fukumoto ◽  
Ryan Noboru Rutherford
Keyword(s):  
Green Tea ◽  
Structure Activity Relationship ◽  
Mechanisms Of Action ◽  
Antibacterial Action ◽  
Activity Relationship ◽  
Tea Catechins ◽  
Structure Activity Relationships ◽  
Green Tea Catechins ◽  
Sar Studies ◽  
Structure Activity

This review summarizes the mechanisms of antibacterial action of green tea catechins, discussing the structure–activity relationship (SAR) studies for each mechanism.

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