Cellular imaging and mitochondria targeted photo-cytotoxicity in visible light by singlet oxygen using a BODIPY-appended oxovanadium(iv) DNA crosslinking agent

MedChemComm ◽  
2016 ◽  
Vol 7 (7) ◽  
pp. 1398-1404 ◽  
Author(s):  
Arun Kumar ◽  
Akanksha Dixit ◽  
Samya Banerjee ◽  
Arnab Bhattacharyya ◽  
Aditya Garai ◽  
...  
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Crosslinking Agent ◽  
Cellular Imaging ◽  
Dna Crosslinking ◽  
Crosslinking Site

Targeted PDT by1O2at mtDNA crosslinking site of a BODIPY-appended VO2+complex in visible light.

BODIPY appended copper(ii) complexes for cellular imaging and singlet oxygen mediated anticancer activity in visible light

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104474-104482 ◽  
Author(s):  
Arnab Bhattacharyya ◽  
Akanksha Dixit ◽  
Samya Banerjee ◽  
Bijan Roy ◽  
Arun Kumar ◽  
...  
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Anticancer Activity ◽  
Cellular Imaging ◽  
Cellular Apoptosis ◽  
Mcf 7

BODIPY-appended copper(ii) complexes are for cellular imaging and visible light-induced remarkable PDT activity in HeLa/MCF-7 cells with1O2-mediated cellular apoptosis.

Mitochondria-localizing BODIPY–copper(ii) conjugates for cellular imaging and photo-activated cytotoxicity forming singlet oxygen

2018 ◽  
Vol 47 (14) ◽  
pp. 5019-5030 ◽  
Author(s):  
Arnab Bhattacharyya ◽  
Aida Jameei ◽  
Aditya Garai ◽  
Rupak Saha ◽  
Anjali A. Karande ◽  
...  
Keyword(s):  
Cell Death ◽  
Visible Light ◽  
Singlet Oxygen ◽  
Apoptotic Cell ◽  
Cellular Imaging ◽  
Apoptotic Cell Death ◽  
Mitochondrial Localization

BODIPY–copper(ii) conjugates are prepared and characterized and the complexes showed mitochondrial localization with singlet oxygen mediated visible light-induced apoptotic cell death.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Extending the excitation wavelength from UV to visible light for a europium complex-based mitochondria targetable luminescent probe for singlet oxygen

2018 ◽  
Vol 47 (37) ◽  
pp. 12852-12857 ◽  
Author(s):  
Hua Ma ◽  
Xin Wang ◽  
Bo Song ◽  
Liu Wang ◽  
Zhixin Tang ◽  
...  
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Europium Complex ◽  
Excitation Wavelength ◽  
Luminescent Probe ◽  
Luminescence Detection

A visible-light-excitable Eu3+ complex-based luminescent probe for the time-gated luminescence detection of singlet oxygen in vitro and in vivo.

scholarly journals Singlet oxygen generation properties of an inclusion complex of cyclic free-base porphyrin dimer and fullerene C60

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18690-18695 ◽  
Author(s):  
Yousuke Ooyama ◽  
Toshiaki Enoki ◽  
Joji Ohshita ◽  
Takuya Kamimura ◽  
Shuwa Ozako ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Visible Light ◽  
Singlet Oxygen ◽  
Visible Light Irradiation ◽  
Fullerene C60 ◽  
Light Irradiation ◽  
Free Base ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Porphyrin Dimer

We demonstrate that a cyclic free-base porphyrin dimer and its inclusion complex with fullerene C60 possess the ability to generate singlet oxygen (1O2) under visible light irradiation.

Degradation of natural toxins by phthalocyanines–example of cyanobacterial toxin, microcystin

2010 ◽  
Vol 62 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Daniel Jančula ◽  
Lucie Bláhová ◽  
Marie Karásková ◽  
Blahoslav Maršálek
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Visible Light ◽  
Singlet Oxygen ◽  
Oxygen Species ◽  
Cyanobacterial Toxin ◽  
Natural Toxins ◽  
Peptide Toxins ◽  
Near Future ◽  
Absorption Characteristics

Phthalocyanines (Pcs) are promising photosensitizers for use in various branches of science and industry. In the presence of visible light and diatomic oxygen, phthalocyanines can react to produce singlet oxygen, a member of reactive oxygen species able to damage different molecules and tissues. The aim of this study was to investigate the ability of phthalocyanines to degrade natural toxins in the presence of visible light. As the representative of hardly degradable toxins, a group of cyanobacterial peptide toxins—microcystin-LR—was chosen for this study. According to our results, phthalocyanines are able to degrade 61,5% of microcystins within a 48-hour incubation (38% of microcystins was degraded after 24 h and 24% after 12 h of incubation). Although other oxidants like hydrogen peroxide or ozone are able to degrade microcystins within several hours, we assume that by optimizing the spectrum emitted by light source and by changing the absorption characteristics of Pcs, microcystins degradation by phthalocyanines could be more effective in the near future.

scholarly journals Electrochemically deposited poly(selenophene)-fullerene photoactive layer: Tuning of the spectroscopic properties towards visible light-driven generation of singlet oxygen

2020 ◽  
Vol 525 ◽  
pp. 146594
Author(s):  
Aleksandra Nyga ◽  
Radoslaw Motyka ◽  
Gianlorenzo Bussetti ◽  
Alberto Calloni ◽  
Madan Sangarashettyhalli Jagadeesh ◽  
...  
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Spectroscopic Properties ◽  
Photoactive Layer ◽  
Electrochemically Deposited ◽  
Visible Light Driven

Visible-Light-Sensitized Photo-Oxidative Cross-Linking of Polysiloxanes Using Singlet Oxygen

2020 ◽  
Vol 2 (11) ◽  
pp. 4802-4808
Author(s):  
Taylor Wright ◽  
Tanja Tomkovic ◽  
Savvas G. Hatzikiriakos ◽  
Michael O. Wolf
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Cross Linking

Tetraphenylethylene conjugated p-hydroxyphenacyl: fluorescent organic nanoparticles for the release of hydrogen sulfide under visible light with real-time cellular imaging

2018 ◽  
Vol 16 (42) ◽  
pp. 7903-7909 ◽  
Author(s):  
C. Parthiban ◽  
Pavithra M. ◽  
L. Vinod Kumar Reddy ◽  
Dwaipayan Sen ◽  
Melvin Samuel S. ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Visible Light ◽  
Real Time ◽  
Cellular Imaging ◽  
Organic Nanoparticles ◽  
Fluorescent Organic Nanoparticles ◽  
Low Concentrations

Hydrogen sulfide (H2S) behaves like a two-edged sword, at low concentrations it has beneficial and cytoprotective effects, while at higher concentrations it exhibits toxicity.

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