scholarly journals Fatty acid transport proteins: targeting FATP2 as a gatekeeper involved in the transport of exogenous fatty acids

MedChemComm ◽  
2016 ◽  
Vol 7 (4) ◽  
pp. 612-622 ◽  
Author(s):  
Paul N. Black ◽  
Constance Ahowesso ◽  
David Montefusco ◽  
Nipun Saini ◽  
Concetta C. DiRusso
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Transport Proteins ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Proteins

FATP2 as the gatekeeper (A), dysregulation of fatty acid metabolism from FA overload (B), and Lipofermata or Grassofermata treatment (C).

scholarly journals Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4

2006 ◽  
Vol 48 (3) ◽  
pp. 609-620 ◽  
Author(s):  
Sandra Lobo ◽  
Brian M. Wiczer ◽  
Ann J. Smith ◽  
Angela M. Hall ◽  
David A. Bernlohr
Keyword(s):  
Functional Analysis ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Transport Proteins ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Proteins

scholarly journals PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid -Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease

PPAR Research ◽  
2009 ◽  
Vol 2009 ◽  
pp. 1-20 ◽  
Author(s):  
James P. Hardwick ◽  
Douglas Osei-Hyiaman ◽  
Homer Wiland ◽  
Mohamed A. Abdelmegeed ◽  
Byoung-Joon Song
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Liver ◽  
Transport Proteins ◽  
Chain Fatty Acid ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Hydroxylase ◽  
Fatty Acid Transport Proteins

Fatty liver disease is a common lipid metabolism disorder influenced by the combination of individual genetic makeup, drug exposure, and life-style choices that are frequently associated with metabolic syndrome, which encompasses obesity, dyslipidemia, hypertension, hypertriglyceridemia, and insulin resistant diabetes. Common to obesity related dyslipidemia is the excessive storage of hepatic fatty acids (steatosis), due to a decrease in mitochondria -oxidation with an increase in both peroxisomal -oxidation, and microsomal -oxidation of fatty acids through peroxisome proliferator activated receptors (PPARs). How steatosis increases PPAR activated gene expression of fatty acid transport proteins, peroxisomal and mitochondrial fatty acid -oxidation and -oxidation of fatty acids genes regardless of whether dietary fatty acids are polyunsaturated (PUFA), monounsaturated (MUFA), or saturated (SFA) may be determined by the interplay of PPARs and HNF4 with the fatty acid transport proteins L-FABP and ACBP. In hepatic steatosis and steatohepatitis, the -oxidation cytochrome P450CYP4Agene expression is increased even with reduced hepatic levels of PPAR. Although numerous studies have suggested the role ethanol-inducibleCYP2E1in contributing to increased oxidative stress,Cyp2e1-null mice still develop steatohepatitis with a dramatic increase inCYP4Agene expression. This strongly implies thatCYP4Afatty acid -hydroxylase P450s may play an important role in the development of steatohepatitis. In this review and tutorial, we briefly describe how fatty acids are partitioned by fatty acid transport proteins to either anabolic or catabolic pathways regulated by PPARs, and we explore how medium-chain fatty acid (MCFA)CYP4Aand long-chain fatty acid (LCFA)CYP4F-hydroxylase genes are regulated in fatty liver. We finally propose a hypothesis that increasedCYP4Aexpression with a decrease inCYP4Fgenes may promote the progression of steatosis to steatohepatitis.

901 A LINK BETWEEN FREE FATTY ACIDS, FATTY ACID TRANSPORT PROTEINS AND APOPTOSIS IN THE PATHOGENESIS OF NASH

2008 ◽  
Vol 48 ◽  
pp. S338
Author(s):  
L.P. Bechmann ◽  
N. Wiesemann ◽  
M. Schlensak ◽  
I. Wedemeier ◽  
M. Odenthal ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Transport Proteins ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Proteins

scholarly journals New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae

2004 ◽  
Vol 63 (2) ◽  
pp. 259-262 ◽  
Author(s):  
Jürgen Pohl ◽  
Axel Ring ◽  
Thomas Herrmann ◽  
Wolfgang Stremmel
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Lipid Rafts ◽  
Transport Proteins ◽  
Fatty Acid Transport ◽  
Long Chain Fatty Acids ◽  
Acid Transport ◽  
Fatty Acid Transport Proteins ◽  
Lcfa Uptake ◽  
Long Chain

Efficient uptake and channelling of long-chain fatty acids (LCFA) are critical cell functions. Evidence is emerging that proteins are important mediators of LCFA-trafficking into cells and various proteins have been suggested to be involved in this process. Amongst these proteins is a family of membrane-associated proteins termed fatty acid transport proteins (FATP). So far six members of this family, designated FATP 1–6, have been characterized. FATP 1, 2 and 6 show a highly-conserved AMP-binding region that participates in the activation of very-long-chain fatty acids (VLCFA) to form their acyl-CoA derivatives. The mechanisms by which FATP mediate LCFA uptake are not well understood, but several studies provide evidence that uptake of LCFA across cellular membranes is closely linked to acyl-CoA synthetase activity. It is proposed that FATP indirectly enhance LCFA uptake by activating VLCFA to their CoA esters, which are required to maintain the typical structure of lipid rafts in cellular membranes. Recent work has shown that the structural integrity of lipid rafts is essential for cellular LCFA uptake. This effect might be exerted by proteins, e.g. caveolin-1 and FAT/CD36, that use lipid rafts as platforms and bind or transport LCFA. The proposed molecular mechanisms await further experimental investigation.

scholarly journals Differential Expression of Fatty Acid Transport Proteins in Epidermis and Skin Appendages

2005 ◽  
Vol 125 (6) ◽  
pp. 1174-1181 ◽  
Author(s):  
Matthias Schmuth ◽  
Angelica M. Ortegon ◽  
Mao-Qiang Man ◽  
Peter M. Elias ◽  
Kenneth R. Feingold ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Differential Expression ◽  
Transport Proteins ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Skin Appendages ◽  
Fatty Acid Transport Proteins
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