Next generation sequencing: implications in personalized medicine and pharmacogenomics

2016 ◽  
Vol 12 (6) ◽  
pp. 1818-1830 ◽  
Author(s):  
Bahareh Rabbani ◽  
Hirofumi Nakaoka ◽  
Shahin Akhondzadeh ◽  
Mustafa Tekin ◽  
Nejat Mahdieh
Keyword(s):  
Next Generation Sequencing ◽  
Personalized Medicine ◽  
Genetic Variations ◽  
Next Generation ◽  
Health And Disease ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

A breakthrough in next generation sequencing (NGS) in the last decade provided an unprecedented opportunity to investigate genetic variations in humans and their roles in health and disease.

scholarly journals Next-generation sequencing (NGS) methods and their application in clinical microbiology, infectology and epidemiology

2021 ◽  
Vol 18 (4) ◽  
pp. 26-32
Author(s):  
V. M. Mitsura
Keyword(s):  
Next Generation Sequencing ◽  
Personalized Medicine ◽  
Infectious Diseases ◽  
Medical Research ◽  
Clinical Microbiology ◽  
Next Generation ◽  
Basic Principles ◽  
Treatment And Prevention ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

This review presents basic principles and methods of next-generation sequencing (NGS) and discusses a number of the latest papers on the possibilities, principles and stages of NGS, as well as the application of NGS in medical research, particularly, clinical microbiology and infectious diseases, epidemiology. The development of NGS technologies will allow improving the results of diagnostics, treatment and prevention of infectious diseases and opens up new prospects for personalized medicine.

scholarly journals Is Next-Generation Sequencing Appropriate for the Clinic?

2014 ◽  
Vol 4 (2) ◽  
pp. 45-48
Author(s):  
Ramzi Hassouneh
Keyword(s):  
Next Generation Sequencing ◽  
Low Cost ◽  
Genomic Medicine ◽  
Clinical Applications ◽  
Next Generation ◽  
Apply Genetic ◽  
Health And Disease ◽  
Next Generation Sequencing Ngs ◽  
The Impact ◽  
Generation Sequencing

Next-generation sequencing (NGS) has ignited a revolution in genomic medicine by eliminating the inherent limitations of conventional sequencing methods. Due to its high throughput and low-cost, clinics can use NGS to perform targeted and genome sequencing to make diagnoses or pre-screen for risk to future disease. Despite its clinical uses, many challenges exist before NGS becomes a mainstay in the clinic. There is a lack of understanding of the impact of genetic variants on health and disease and how to best apply genetic information to patient care. Nevertheless, the translation of base pair reads to clinical applications has truly begun.

scholarly journals Pharmacogenomics, How to Deal with Different Types of Variants in Next Generation Sequencing Data in the Personalized Medicine Area

2020 ◽  
Vol 10 (1) ◽  
pp. 34
Author(s):  
Alireza Tafazoli ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Renata Posmyk ◽  
Wojciech Miltyk
Keyword(s):  
Next Generation Sequencing ◽  
Personalized Medicine ◽  
Next Generation Sequencing Data ◽  
Next Generation ◽  
Sequencing Data ◽  
Clinical Practices ◽  
Clinical Investigations ◽  
Different Types ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Pharmacogenomics (PGx) is the knowledge of diverse drug responses and effects in people, based on their genomic profiles. Such information is considered as one of the main directions to reach personalized medicine in future clinical practices. Since the start of applying next generation sequencing (NGS) methods in drug related clinical investigations, many common medicines found their genetic data for the related metabolizing/shipping proteins in the human body. Yet, the employing of technology is accompanied by big obtained data, which most of them have no clear guidelines for consideration in routine treatment decisions for patients. This review article talks about different types of NGS derived PGx variants in clinical studies and try to display the current and newly developed approaches to deal with pharmacogenetic data with/without clear guidelines for considering in clinical settings.

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