scholarly journals A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

Lab on a Chip ◽  
2017 ◽  
Vol 17 (1) ◽  
pp. 134-144 ◽  
Author(s):  
J. R. Coppeta ◽  
M. J. Mescher ◽  
B. C. Isenberg ◽  
A. J. Spencer ◽  
E. S. Kim ◽  
...  
Keyword(s):  
Drug Development ◽  
Flow Control ◽  
High Precision ◽  
Microfluidic Flow ◽  
Microphysiological Systems ◽  
Organ Model

A microphysiological systems platform with high precision onboard flow control supports organ model crosstalk for up to 2 weeks.

scholarly journals Phase-selective graphene oxide membranes for advanced microfluidic flow control

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Jennifer Gaughran ◽  
David Boyle ◽  
James Murphy ◽  
Robert Kelly ◽  
Jens Ducrée
Keyword(s):  
Graphene Oxide ◽  
Flow Control ◽  
Microfluidic Flow ◽  
Oxide Membranes ◽  
Graphene Oxide Membranes

Multichannel Catalyst-Testing Reactor with Microfluidic Flow Control

2001 ◽  
Vol 73 (6) ◽  
pp. 661-661 ◽  
Author(s):  
Y Y Low ◽  
V Tesar ◽  
J R Tippetts ◽  
M J Pitt ◽  
R W K Allen
Keyword(s):  
Flow Control ◽  
Microfluidic Flow

scholarly journals Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

2015 ◽  
Vol 7 (4) ◽  
pp. 383-391 ◽  
Author(s):  
Hasan Erbil Abaci ◽  
Michael L. Shuler
Keyword(s):  
Drug Development ◽  
Development Studies ◽  
Human Tissues ◽  
Design Strategies ◽  
Physiologically Based Pharmacokinetics ◽  
Microfluidic Platforms ◽  
Chip Design ◽  
Microphysiological Systems ◽  
Physiologically Based

Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies.

scholarly journals Anti-Counterfeit Technologies for Microfluidic “Lab-on-a-Disc” Systems

2021 ◽  
Author(s):  
Jens Ducrée
Keyword(s):  
Flow Control ◽  
Point Of Care ◽  
Significant Risk ◽  
Online Database ◽  
Medical Products ◽  
Digital Twin ◽  
Economy Of Scale ◽  
Microfluidic Flow ◽  
Significant Damage ◽  
Hardware Encryption

Non-genuine medical products, including diagnostic devices, have become a lucrative business for fraudsters, causing significant damage to revenues and reputation of companies, as well as posing a significant risk to the health of people and societies. Along a “digital twin” representing centrifugal microfluidic flow control on exemplary “Lab-on-a-Disc” (LoaD) systems, a novel, two-pronged strategy to safeguard miniaturized point-of-care devices by means of secret features and manufacturing challenges is outlined; such “hardware encryption” is flexibly programmed for each chip during production, and deciphered from a secure, local or online database at the time of use. This way, unlicensed copying may be efficiently deterred by an unfavourable economy-of-scale, even in absence of legal prosecution.

scholarly journals Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development

2021 ◽  
pp. 1-13
Author(s):  
Passley Hargrove-Grimes ◽  
Lucie A. Low ◽  
Danilo A. Tagle
Keyword(s):  
Human Physiology ◽  
Pharmaceutical Industry ◽  
Drug Development ◽  
End Users ◽  
Regulatory Agencies ◽  
Functional Level ◽  
Multiple Stakeholder ◽  
Widespread Adoption ◽  
Microphysiological Systems

Microphysiological systems (MPS) or tissue chips/organs-on-chips are novel <i>in vitro</i> models that emulate human physiology at the most basic functional level. In this review, we discuss various hurdles to widespread adoption of MPS technology focusing on issues from multiple stakeholder sectors, e.g., academic MPS developers, commercial suppliers of platforms, the pharmaceutical and biotechnology industries, and regulatory organizations. Broad adoption of MPS technology has thus far been limited by a gap in translation between platform developers, end-users, regulatory agencies, and the pharmaceutical industry. In this brief review, we offer a perspective on the existing barriers and how end-users may help surmount these obstacles to achieve broader adoption of MPS technology.

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