Robust regulation of hepatic pericentral amination by glutamate dehydrogenase kinetics

2016 ◽  
Vol 8 (11) ◽  
pp. 1126-1132 ◽  
Author(s):  
Soumen Bera ◽  
Sanjay Lamba ◽  
Mubasher Rashid ◽  
Anuj K. Sharma ◽  
Alexander B. Medvinsky ◽  
...  

α-Ketoglutarate substrate inhibition kinetics of hepatic glutamate dehydrogenase amination activity confers robust control over the ratio between glutamate and ammonium.

2000 ◽  
Vol 72 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Chetan T. Goudar ◽  
Shobha H. Ganji ◽  
Basayya G. Pujar ◽  
Keith A. Strevett

2004 ◽  
Vol 4 (1) ◽  
pp. 56-61 ◽  
Author(s):  
B.O. Oboirien . ◽  
B. Amigun . ◽  
T.V. Ojumu . ◽  
O.A. Ogunkunle . ◽  
O.A. Adetunji . ◽  
...  

Chlorophenols are listed as priority pollutants both by European community and US EPA. Biodegradation of pchlorophenol (4-CP) was investigated in batch shake flasks by Arthrobacter chlorophenolicus A6 at initial 4-CP concentrations between 25 to 350 mgl-1. The rate of 4-CP removal decreased with increasing initial 4-CP concentrations due to toxic effects on the microorganisms. The growth and biodegradation kinetic of the culture was evaluated. The batch growth profile of the A chlorophenolicus A6 followed substrate inhibition kinetics with the estimated biokinetic parameters of Ksi = 272 mgl-1, Ks = 65 mgl-1 for 4-CP respectively. High inhibition constant (KSI = 272 mg -l) with a KSI/KS ratio of 4.18 indicates superior 4-CP biodegradation potential of the A chlorophenolicus A6. The maximum rate of 4-CP degradation has been achieved at an optimum substrate concentration of Smax = (KSKSI)1/2 = (65×272)1/2 = 133 mgl−1.


2019 ◽  
Vol 152 ◽  
pp. 214-220
Author(s):  
Abubakar Aisami ◽  
Nur Adeela Yasid ◽  
Wan Lutfi Wan Johari ◽  
Siti Aqlima Ahmad ◽  
Mohd Yunus Shukor

2021 ◽  
Vol 54 (3) ◽  
pp. 318-323
Author(s):  
Thomas Emil Ryde ◽  
Morten Ryberg Wahlgreen ◽  
Marcus Krogh Nielsen ◽  
Steen Hørsholt ◽  
Sten Bay Jørgensen ◽  
...  

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