Metal-free radical C–H methylation of pyrimidinones and pyridinones with dicumyl peroxide

2017 ◽  
Vol 19 (4) ◽  
pp. 919-923 ◽  
Author(s):  
Pei-Zhi Zhang ◽  
Jian-An Li ◽  
Ling Zhang ◽  
Adedamola Shoberu ◽  
Jian-Ping Zou ◽  
...  
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Metal Free

A method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely. The product was separated by crystallization and the byproducts were recovery by distillation.

Metal-Free Cascade Methylation/Cyclization of N-Alkyl-N-methacryloylbenzamides with Dicumyl Peroxide

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 617-620 ◽  
Author(s):  
Yan-Ning Niu ◽  
Xiao-Feng Xia ◽  
Yuan Yuan
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Metal Free ◽  
Wide Range ◽  
Radical Cascade ◽  
Convenient Access

A metal-free radical cascade methylation/cyclization of a wide range of N-alkyl-N-methacryloylbenzamides by using dicumyl peroxide as the methylating reagent provides a convenient access to a series of methylated isoquinoline-1,3-diones in moderate yields.

Metal-free radical cascade dichloromethylation of activated alkenes using CH2Cl2: highly selective activation of the C–H bond

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64855-64859 ◽  
Author(s):  
Yunfei Tian ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Cascade Process ◽  
Selective Activation ◽  
Metal Free ◽  
Efficient Access ◽  
Radical Cascade

A dicumyl peroxide-initiated highly selective activation of the (sp3)C–H bond in dichloromethane (DCM, CH2Cl2) has been achieved, which allows efficient access to dichloronated oxindoles via a free-radical cascade process.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

scholarly journals Synthesis of Polychloromethyl-Containing Indolines via Metal-Free Radical Arylpolychloromethylation of Unactivated Alkenes

2019 ◽  
Vol 39 (6) ◽  
pp. 1727 ◽  
Author(s):  
Wenlan Li ◽  
Yitong Sun ◽  
Yongchao Yao ◽  
Ying Xu ◽  
Peng Li ◽  
...  
Keyword(s):  
Free Radical ◽  
Metal Free

scholarly journals Transition-Metal-Free Radical C(sp3)–C(sp2) and C(sp3)–C(sp3) Coupling Enabled by 2-Azaallyls as Super-Electron-Donors and Coupling-Partners

2017 ◽  
Vol 139 (45) ◽  
pp. 16327-16333 ◽  
Author(s):  
Minyan Li ◽  
Simon Berritt ◽  
Lucas Matuszewski ◽  
Guogang Deng ◽  
Ana Pascual-Escudero ◽  
...  
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Electron Donors ◽  
Metal Free

Metal-Free Radical [2+2+1] Carbocyclization of Benzene-Linked 1,n-Enynes: Dual C(sp3)H Functionalization Adjacent to a Heteroatom

2015 ◽  
Vol 127 (33) ◽  
pp. 9713-9716 ◽  
Author(s):  
Ming Hu ◽  
Jian-Hong Fan ◽  
Yu Liu ◽  
Xuan-Hui Ouyang ◽  
Ren-Jie Song ◽  
...  
Keyword(s):  
Free Radical ◽  
Metal Free

Magnetic behavior in metal-free radical thin films

Chem ◽  
2021 ◽  
Author(s):  
Tobias Junghoefer ◽  
Arrigo Calzolari ◽  
Ivan Baev ◽  
Mathias Glaser ◽  
Francesca Ciccullo ◽  
...  
Keyword(s):  
Thin Films ◽  
Free Radical ◽  
Magnetic Behavior ◽  
Metal Free

Metal‐Free Radical Annulation‐Hydrofunctionalization of 1,6‐Enynes for Stereoselective Synthesis of ( E )‐1‐Indanones

2020 ◽  
Vol 9 (7) ◽  
pp. 1040-1044 ◽  
Author(s):  
Ya‐Nan Wu ◽  
Tian‐Shu Zhang ◽  
Wen‐Juan Hao ◽  
Shu‐Jiang Tu ◽  
Bo Jiang
Keyword(s):  
Free Radical ◽  
Stereoselective Synthesis ◽  
Metal Free
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