scholarly journals An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit

2017 ◽  
Vol 19 (1) ◽  
pp. 249-258 ◽  
Author(s):  
S. Abou-Shehada ◽  
P. Mampuys ◽  
B. U. W. Maes ◽  
J. H. Clark ◽  
L. Summerton
Keyword(s):  
Organic Compounds ◽  
Multicomponent Reaction ◽  
Multicomponent Reactions ◽  
Materials Used

Multicomponent reactions (MCRs) are considered green and material efficient methods for the synthesis of organic compounds, however very few studies have investigated the metrics of the upstream processes involved to achieve the starting materials used in these reactions.

Pot, atom and step-economic (PASE) synthesis of medicinally relevant spiro[oxindole-3,4′-pyrano[4,3-b]pyran] scaffold

2016 ◽  
Vol 22 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Michail N. Elinson ◽  
Fedor V. Ryzhkov ◽  
Victor A. Korolev ◽  
Mikhail P. Egorov
Keyword(s):  
Multicomponent Reaction ◽  
Multicomponent Reactions ◽  
Large Scale ◽  
Potassium Fluoride ◽  
Environmentally Benign ◽  
Anti Hiv

AbstractFast (3 min) pot, atom and step economics (PASE) potassium fluoride catalyzed multicomponent reaction of isatins, malononitrile and 4-hydroxy-6-methyl-2H-pyran-2-one results in efficient formation of substituted spirooxindole-3,4′-pyrano[4,3-b]pyrans in 92–96% yields. The developed ‘on-solvent’ approach to the substituted spirooxindole-3,4′-pyrano[4,3-b]pyrans – the pharmacologically perspective substances with known antiviral, antileishmanial, anticonvulsant and anti-HIV activities – is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast and environmentally benign synthetic concept for the multicomponent reactions strategy.

scholarly journals Nanotechnology for Environmental Remediation: Materials and Applications

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1760 ◽  
Author(s):  
Fernanda Guerra ◽  
Mohamed Attia ◽  
Daniel Whitehead ◽  
Frank Alexis
Keyword(s):  
Organic Compounds ◽  
Environmental Remediation ◽  
Organophosphorus Compounds ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Chlorinated Organic Compounds ◽  
Environmental Media ◽  
Chlorinated Organic ◽  
Materials Used

Environmental remediation relies mainly on using various technologies (e.g., adsorption, absorption, chemical reactions, photocatalysis, and filtration) for the removal of contaminants from different environmental media (e.g., soil, water, and air). The enhanced properties and effectiveness of nanotechnology-based materials makes them particularly suitable for such processes given that they have a high surface area-to-volume ratio, which often results in higher reactivity. This review provides an overview of three main categories of nanomaterials (inorganic, carbon-based, and polymeric-based materials) used for environmental remediation. The use of these nanomaterials for the remediation of different environmental contaminants—such as heavy metals, dyes, chlorinated organic compounds, organophosphorus compounds, volatile organic compounds, and halogenated herbicides—is reviewed. Various recent examples are extensively highlighted focusing on the materials and their applications.

scholarly journals Synthesis of Biologically Active Molecules through Multicomponent Reactions

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 505 ◽  
Author(s):  
Daniel Insuasty ◽  
Juan Castillo ◽  
Diana Becerra ◽  
Hugo Rojas ◽  
Rodrigo Abonia
Keyword(s):  
Multicomponent Reaction ◽  
Biological Property ◽  
Multicomponent Reactions ◽  
Organic Molecules ◽  
Biological Activities ◽  
Biologically Active ◽  
Vast Number ◽  
Key Points ◽  
Reported Data ◽  
Synthetic Approaches

Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that many of such molecules are biologically active or at least have been submitted to any biological screen. The selected papers covered in this review must meet two mandatory requirements: (1) the reported products should be obtained via a multicomponent reaction; (2) the reported products should be biologically actives or at least tested for any biological property. Given the diversity of synthetic approaches utilized in MCRs, the highly diverse nature of the biological activities evaluated for the synthesized compounds, and considering their huge structural variability, much of the reported data are organized into concise schemes and tables to facilitate comparison, and to underscore the key points of this review.

scholarly journals Concise Synthesis of Macrocycles by Multicomponent Reactions

Synthesis ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 1027-1038 ◽  
Author(s):  
Alexander Dömling ◽  
Eman Abdelraheem ◽  
Samad Khaksar
Keyword(s):  
Amino Acid ◽  
Multicomponent Reaction ◽  
Ring Opening ◽  
Multicomponent Reactions ◽  
Reaction Pathway ◽  
Ring Closure ◽  
Side Chains ◽  
Reaction Sequence ◽  
Cyclic Anhydride

A short reaction pathway was devised to synthesize a library of artificial 18–27-membered macrocycles. The five-step reaction sequence involves ring opening of a cyclic anhydride with a diamine, esterification, coupling with an amino acid isocyanide, saponification, and, finally, macro-ring closure using an Ugi or, alternatively, a Passerini multicomponent reaction. Three out of the five steps allow for the versatile introduction of linker elements, side chains, and substituents with aromatic, heteroaromatic, and aliphatic character. The versatile pathway is described for 15 different target macrocycles on a mmol scale. Artificial macrocycles have recently become of great interest due to their potential to bind to difficult post-genomic targets.

scholarly journals Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Biswa Mohan Sahoo ◽  
B. V. V. Ravi Kumar ◽  
Jnyanaranjan Panda ◽  
S. C. Dinda
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Multicomponent Reaction ◽  
Multicomponent Reactions ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Heating Method ◽  
Green Protocol ◽  
Drug Molecules

A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1HNMR spectral data.

scholarly journals A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction

2011 ◽  
Vol 7 ◽  
pp. 962-975 ◽  
Author(s):  
Christian Eidamshaus ◽  
Roopender Kumar ◽  
Mrinal K Bera ◽  
Hans-Ulrich Reissig
Keyword(s):  
Lactic Acid ◽  
Carboxylic Acids ◽  
Multicomponent Reaction ◽  
Multicomponent Reactions ◽  
Practical Approach ◽  
Side Chains ◽  
Step Process ◽  
Step Procedure ◽  
Cyclocondensation Reaction

A practical approach to highly functionalized 4-hydroxypyridine derivatives with stereogenic side chains in the 2- and 6-positions is described. The presented two-step process utilizes a multicomponent reaction of alkoxyallenes, nitriles and carboxylic acids to provide β-methoxy-β-ketoenamides which are transformed into 4-hydroxypyridines in a subsequent cyclocondensation. The process shows broad substrate scope and leads to differentially substituted enantiopure pyridines in good to moderate yields. The preparation of diverse substituted lactic acid derived pyrid-4-yl nonaflates is described. Additional evidence for the postulated mechanism of the multicomponent reaction is presented.

scholarly journals Monitoring Of Pollutants In Museum Environment

2015 ◽  
Vol 9 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Budu Ana-Maria ◽  
Sandu Ion
Keyword(s):  
Organic Compounds ◽  
Inorganic Compounds ◽  
Pollution Source ◽  
Direct Reading ◽  
Inorganic Particles ◽  
Skin Cells ◽  
Art Objects ◽  
Art Works ◽  
Materials Used ◽  
Acidic Compounds

Abstract Art works are affected by environmental factors as light, temperature, humidity. Air pollutants are also implicated in their degradation. The pollution in museums has two sources: the air from outside, which brings usually dust and inorganic particles, and the inside sources – the materials used for casings (sealants, textiles placed on the display cases, varnishes, wood) that emanate organic compounds. The dust is composed of particles with a diameter of approximately 2µm or higher, which come from soil (silica) or animal and vegetal residues (skin cells, pollen). They facilitate water condensation on objects surface and biologic attack. The inorganic compounds are a result of materials combustion (SO2, NO2, NO) and in presence of water they form acidic compounds which affect the museum objects. The organic compounds are usually peroxides, acids, phthalates, formaldehyde. The effects of these pollutants are: soiling, surface discolouration, embrittlement, corrosion. Therefore, conservators are interested in monitoring the pollution degree in the display cases or in the museum air and in analyzing the effects of pollutants on the exhibited objects. They use different methods for pollutants identification, like direct reading devices based on colorimetry, that can be read after few minutes and hours (they interact with the pollutants in atmosphere), or indirect reading samples that require a laboratory. The information gathered is used for the identification of pollution source and to analyze the concentration of pollutants needed to provoke damages on the surfaces of art objects. This paper is a review of pollutants that affect the art objects and of the monitoring systems used for their identification and measuring.

scholarly journals Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

2016 ◽  
Vol 12 ◽  
pp. 1269-1301 ◽  
Author(s):  
Mohammad Haji
Keyword(s):  
Organic Compounds ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Synthetic Chemistry ◽  
Phosphonate Group ◽  
Wide Range ◽  
Efficient Route ◽  
Organophosphorus Chemistry

Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

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