scholarly journals Preparation and comparison of bulk and membrane hydrogels based on Kraft- and ionic-liquid-isolated lignins

2016 ◽  
Vol 18 (20) ◽  
pp. 5607-5620 ◽  
Author(s):  
Xiaoping Shen ◽  
Paula Berton ◽  
Julia L. Shamshina ◽  
Robin D. Rogers
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Polyethylene Glycol ◽  
Alkaline Solution ◽  
Wound Dressing ◽  
Food Packaging ◽  
Potential Drug

Lignin-based hydrogels in both bulk and membrane forms for potential drug delivery, food packaging, and wound dressing applications have been designed by crosslinking ionic-liquid-isolated lignin with epoxide-terminated polyethylene glycol (ETPEG) in alkaline solution.

scholarly journals Functionalization of Biotinylated Polyethylene Glycol on Live Magnetotactic Bacteria Carriers for Improved Stealth Properties

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 993
Author(s):  
Richa Chaturvedi ◽  
Yumin Kang ◽  
Yunji Eom ◽  
Sri Ramulu Torati ◽  
CheolGi Kim
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Carrier ◽  
Magnetotactic Bacteria ◽  
Biological Applications ◽  
Potential Drug ◽  
Time Saving ◽  
Area Of Interest ◽  
Cell Association

The early removal of drug delivery agents before reaching the affected target remains an area of interest to researchers. Several magnetotactic bacteria (MTB) have been used as self-propelled drug delivery agents, and they can also be controlled by an external magnetic field. By attaching the PEG–biotin polymer, the bacteria are turned into a stealth material that can escape from the phagocytosis process and reach the area of interest with the drug load. In the study, we developed a potential drug carrier by attaching the PEG–biotin to the MTB-through-NHS crosslinker to form a MTB/PEG–biotin complex. The attachment stability, efficacy, and bacterial viability upon attachment of the PEG–biotin polymer were investigated. Biological applications were carried out using a cytotoxicity assay of THP-1 cells, and the results indicate that the MTB/PEG–biotin complex is less harmful to cell viability compared to MTB alone. Along with cytotoxicity, an assay for cell association was also evaluated to assess the complex as a potential stealth material. The development of these complexes focuses on an easy, time-saving, and stable technique of polymer attachment with the bacteria, without damaging the cell’s surface, so as to make it a strong and reliable delivery agent.

scholarly journals Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3067
Author(s):  
Mustafa A. Jihad ◽  
Farah T. M. Noori ◽  
Majid S. Jabir ◽  
Salim Albukhaty ◽  
Faizah A. AlMalki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Grain Size ◽  
Cell Wall ◽  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Nucleic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nigella Sativa ◽  
Seed Extract

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

Bioevaluation of glucose-modified liposomes as a potential drug delivery system for cancer treatment using 177-Lu radiotracking

2021 ◽  
Vol 332 ◽  
pp. 301-311
Author(s):  
Đorđe Cvjetinović ◽  
Željko Prijović ◽  
Drina Janković ◽  
Magdalena Radović ◽  
Marija Mirković ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug

scholarly journals Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1347
Author(s):  
Arbanah Muhammad ◽  
Dabin Lee ◽  
Yonghun Shin ◽  
Juhyun Park
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Wound Dressing ◽  
Freeze Drying ◽  
Recent Progress ◽  
Present Review ◽  
Porous Structures ◽  
Air Filtration ◽  
Future Outlook ◽  
Synthetic Process

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

Graphene oxide/polyethylene glycol aerogel reinforced with grape seed extracts as wound dressing

2021 ◽  
Author(s):  
Jessica Borges-Vilches ◽  
Javiera Poblete ◽  
Fernando Gajardo ◽  
Claudio Aguayo ◽  
Katherina Fernández
Keyword(s):  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Wound Dressing ◽  
Grape Seed ◽  
Grape Seed Extracts ◽  
Seed Extracts

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

2021 ◽  
Author(s):  
Amlika Rungrod ◽  
Apichaya Kapanya ◽  
Winita Punyodom ◽  
Robert Molloy ◽  
Jomkhwan Meerak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Dressing ◽  
Controlled Drug Delivery

Drug delivery via anion exchange of salicylate decorating poly(meth)acrylates based on a pharmaceutical ionic liquid

2017 ◽  
Vol 41 (21) ◽  
pp. 12801-12807 ◽  
Author(s):  
Rafał Bielas ◽  
Dariusz Łukowiec ◽  
Dorota Neugebauer
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Anion Exchange ◽  
Drug Carriers ◽  
Phosphate Anions

Poly[trimethylammonium (meth)acrylate]s decorated by salicylate anions were investigated as drug carriers. Efficient exchange of drug was provided by phosphate anions contained in the medium within 4 h.

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