Protective effects of fraction 4a of polysaccharides isolated from Lycium barbarum against KBrO3-induced renal damage in rats

2017 ◽  
Vol 8 (7) ◽  
pp. 2566-2572 ◽  
Author(s):  
J. Li ◽  
M. Shi ◽  
B. Ma ◽  
Y. Zheng ◽  
R. Niu ◽  
...  
Keyword(s):  
Oxidation Resistance ◽  
Renal Damage ◽  
Protective Effects ◽  
Renal Cells ◽  
Lycium Barbarum

LBP-4a exhibits protective effects on KBrO3-induced renal damage, and the mechanism correlates with the increase of oxidation resistance in renal cells.

scholarly journals Enhancing the Cardiovascular Protective Effects of a Healthy Dietary Pattern with Wolfberry (Lycium barbarum): A Randomized Controlled Trial

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 82-82
Author(s):  
Darel Wee Kiat Toh ◽  
Xuejuan Xia ◽  
Jasmine Hui Min Low ◽  
Clarinda Sutanto ◽  
Wan Yee Lee ◽  
...  
Keyword(s):  
Older Adults ◽  
Randomized Controlled Trial ◽  
Dietary Pattern ◽  
Cardiovascular Health ◽  
Controlled Trial ◽  
Protective Effects ◽  
Lycium Barbarum ◽  
Endothelin 1 ◽  
Randomized Controlled ◽  
Healthy Dietary Pattern

Abstract Objectives The study aimed to investigate the impact of wolfberry (Lycium barbarum) consumption as part of a healthy dietary pattern on cardiovascular health in Singaporean middle-aged and older adults. It was hypothesized that the consumption of wolfberry could further enhance the cardiovascular protective effects of a healthy dietary pattern. Methods This was a 16 week, parallel design, randomized controlled trial where 40 Singaporean men and women (aged 50 to 64 years) received dietary counselling to follow a healthy dietary pattern either with or without 15 g/day of dried whole wolfberry, cooked and consumed as part of their meals. Blood pressure, serum lipid-lipoprotein concentrations and dietary compliance using 3-day food records were monitored every 4 weeks. Further evaluation of cardiovascular disease (CVD) biomarkers, broadly classified as serological (total nitrate/nitrite, endothelin-1, intercellular adhesion molecule-1, angiopoietin-1, angiopoietin-2 and von-Willebrand factor), structural (carotid intima-media thickness using B-mode ultrasonography) and functional (flow-mediated dilation using B-mode ultrasonography and circulating endothelial progenitor cells (CD34+/KDR+) by fluorescence-activated cell sorting) were analyzed before and after intervention. Results Adherence to a healthy dietary pattern contributed to a time dependent effect on both the plasma total nitrate/nitrite (P < 0.01) and plasma endothelin-1 (P < 0.005) which were raised and lowered respectively at week 16. However, changes were significant only in the wolfberry group (total nitrate/nitrite: 15.9 ± 1.8 to 19.4 ± 2.2 μmol/L, P < 0.05; endothelin-1: 1.31 ± 0.12 to 1.11 ± 0.10 ng/L, P < 0.01) and not in the control group. Moreover, a significant increase in serum high density lipoprotein (HDL) cholesterol was also detected solely in the wolfberry group (1.56 ± 0.10 to 1.65 ± 0.10 mmol/L, P < 0.05). The other serological, structural and functional biomarkers of cardiovascular health showed no observable change after the intervention. Conclusions Incorporating wolfberry to your daily meals may augment the cardiovascular protective benefits of a healthy dietary pattern by improving the regulation of vascular tone and plasma lipid-lipoprotein profile in Singaporean middle-aged and older adults. Funding Sources Ministry of Education, Singapore.

scholarly journals Correction to: Heat stress-induced renal damage in poultry and the protective effects of HSP60 and HSP47

2020 ◽  
Vol 25 (2) ◽  
pp. 379-379
Author(s):  
Shu Tang ◽  
Shuang Zhou ◽  
Bin Yin ◽  
Jiao Xu ◽  
Liangjiao Di ◽  
...  
Keyword(s):  
Heat Stress ◽  
Renal Damage ◽  
Protective Effects

scholarly journals Protective effects of protocatechuic acid against cisplatin-induced renal damage in rats

2015 ◽  
Vol 19 ◽  
pp. 20-27 ◽  
Author(s):  
Noriko Yamabe ◽  
Jun Yeon Park ◽  
Seungyong Lee ◽  
Eun-Ju Cho ◽  
Sanghyun Lee ◽  
...  
Keyword(s):  
Renal Damage ◽  
Protocatechuic Acid ◽  
Protective Effects

scholarly journals Heat stress-induced renal damage in poultry and the protective effects of HSP60 and HSP47

2018 ◽  
Vol 23 (5) ◽  
pp. 1033-1040 ◽  
Author(s):  
Shu Tang ◽  
Shuang Zhou ◽  
Bin Yin ◽  
Jiao Xu ◽  
Liangjiao Di ◽  
...  
Keyword(s):  
Heat Stress ◽  
Renal Damage ◽  
Protective Effects

Protective Effects of Serotonin and its Derivatives, N-Feruloylserotonin and N-(p-Coumaroyl) Serotonin, Against Cisplatin-Induced Renal Damage in Mice

2019 ◽  
Vol 47 (02) ◽  
pp. 369-383 ◽  
Author(s):  
Chan Hum Park ◽  
Ah Young Lee ◽  
Ji Hyun Kim ◽  
Su Hui Seong ◽  
Eun Ju Cho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Renal Damage ◽  
Pleiotropic Effect ◽  
Protective Effects ◽  
Related Protein ◽  
Renoprotective Effect ◽  
Serotonin Derivatives ◽  
Mitogen Activated Protein ◽  
Apoptosis Related Protein

This study examined whether serotonin and two of its derivatives, [Formula: see text]-feruloylserotonin and [Formula: see text]-([Formula: see text]-coumaroyl) serotonin, have a renoprotective effect in a mouse model of cisplatin-induced acute renal failure. Cisplatin (20[Formula: see text]mg/kg body weight) was administered by intraperitoneal injection to male BALB/c mice that had received oral serotonin, [Formula: see text]-feruloylserotonin or [Formula: see text]-([Formula: see text]-coumaroyl) serotonin (7.5[Formula: see text]mg/kg body weight per day) during the preceding 2 days. At 3 days after the cisplatin injection, serum and renal biochemical factors, oxidative stress, inflammation and apoptosis-related protein expression were evaluated, and histological examinations were performed. Cisplatin caused reduction in body weight and an increase in kidney weight; however, [Formula: see text]-([Formula: see text]-coumaroyl) serotonin and [Formula: see text]-feruloylserotonin attenuated these effects. Moreover, the serotonin derivatives significantly decreased serum urea nitrogen and creatinine levels. They also significantly reduced the level of reactive oxygen species and upregulated the expression of glutathione peroxidase in the kidney. Furthermore, the serotonin derivatives improved the abnormal expression of mitogen-activated protein kinases activation-dependent inflammation- and apoptosis-related protein and caused less renal damage. These results provide important evidence that [Formula: see text]-([Formula: see text]-coumaroyl) serotonin and [Formula: see text]-feruloylserotonin exert a pleiotropic effect on several parameters related to oxidative stress, inflammation and apoptosis. The derivatives also have a renoprotective effect in cisplatin-treated mice; however, this effect is higher with [Formula: see text]-([Formula: see text]-coumaroyl) serotonin.

scholarly journals Protective Effects of Recombinant Human Soluble Thrombomodulin on Lipopolysaccharide-Induced Acute Kidney Injury

2020 ◽  
Vol 21 (7) ◽  
pp. 2519
Author(s):  
Yuji Nozaki ◽  
Jinhai Ri ◽  
Kenji Sakai ◽  
Kaoru Niki ◽  
Masanori Funauchi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Damage ◽  
Cell Activation ◽  
Therapeutic Strategy ◽  
Cytokine Production ◽  
Kidney Injury ◽  
Protective Effects ◽  
Inflammatory Cytokine Production ◽  
Soluble Thrombomodulin ◽  
Anticoagulant Function

Thrombomodulin (TM) is a single transmembrane, multidomain glycoprotein receptor for thrombin, and is best known for its role as a cofactor in a clinically important natural anticoagulant pathway. In addition to its anticoagulant function, TM has well-defined anti-inflammatory properties. Soluble TM levels increase significantly in the plasma of septic patients; however, the possible involvement of recombinant human soluble TM (rTM) transduction in the pathogenesis of lipopolysaccharide (LPS)-induced nephrotoxicity, including acute kidney injury (AKI), has remained unclear. Mice were injected intraperitoneally with 15 mg/kg LPS. rTM (3 mg/kg) or saline was administered to the animals before the 3 and 24 h LPS-injection. At 24 and 48 h, blood urea nitrogen, the inflammatory cytokines in sera and kidney, and histological findings were assessed. Cell activation and apoptosis signal was assessed by Western blot analysis. In this study using a mouse model of LPS-induced AKI, we found that rTM attenuated renal damage by reducing both cytokine and cell activation and apoptosis signals with the accumulation of CD4+ T-cells, CD11c+ cells, and F4/80+ cells via phospho c-Jun activations and Bax expression. These findings suggest that the mechanism underlying these effects of TM may be mediated by a reduction in inflammatory cytokine production in response to LPS. These molecules might thereby provide a new therapeutic strategy in the context of AKI with sepsis.

scholarly journals Selenium and rutin alone or in combination do not have stronger protective effects than their separate effects against cadmium-induced renal damage

2015 ◽  
Vol 54 (5) ◽  
pp. 896-904 ◽  
Author(s):  
Sunny O. Abarikwu ◽  
Olusegun L. Adebayo ◽  
Chiagoziem A. Otuechere ◽  
Blessing O. Iserhienrhien ◽  
Temitope A. Badejo
Keyword(s):  
Renal Damage ◽  
Protective Effects

The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats

2012 ◽  
Vol 15 ◽  
pp. 65-71 ◽  
Author(s):  
Chun-Kun Hu ◽  
Yih-Jing Lee ◽  
Carmen M. Colitz ◽  
Ching-Jin Chang ◽  
Chung-Tien Lin
Keyword(s):  
Protective Effects ◽  
Lycium Barbarum
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