scholarly journals Oral administration of green algae, Euglena gracilis, inhibits hyperglycemia in OLETF rats, a model of spontaneous type 2 diabetes

2016 ◽  
Vol 7 (11) ◽  
pp. 4655-4659 ◽  
Author(s):  
Ryoko Shimada ◽  
Miho Fujita ◽  
Masahiro Yuasa ◽  
Hiromi Sawamura ◽  
Toshiaki Watanabe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Oral Administration ◽  
Green Algae ◽  
Euglena Gracilis ◽  
Oletf Rats ◽  
Long Evans

In the present study, the effects of Euglena and paramylon on hyperglycemia were examined in Otsuka Long–Evans Tokushima fatty (OLETF; type 2 diabetes mellitus model) rats.

Reductions in Intestinal Taurine-Conjugated Bile Acids and Short-Chain Fatty Acid-Producing Bacteria Might be Novel Mechanisms of Type 2 Diabetes Mellitus in Otsuka Long-Evans Tokushima Fatty Rats

2021 ◽  
Author(s):  
Xiaoyun Yang ◽  
Wenhui Jiang ◽  
Jingli Cheng ◽  
Jintong Hao ◽  
Fei Han ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Oletf Rats ◽  
Fasting Plasma ◽  
Long Evans ◽  
Conjugated Bile Acids

Abstract Background The pathogenesis of spontaneously diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, among the best models for human type 2 diabetes mellitus (T2DM), remains poorly defined. Therefore, we investigated the dynamic changes in taurine-conjugated bile acids (T-BAs) and intestinal microbiota during T2DM development in OLETF rats. Methods OLETF rats and corresponding diabetes-resistant Long Evans Tokushima Otsuka (LETO) rats were fed a normal baseline diet. The progress of T2DM was divided into four phases, including normal glycemia-normal insulinemia (baseline), normal glycemia-hyperinsulinemia, impaired glucose tolerance, and DM. Body weight, liver function, blood lipids, fasting plasma glucose, fasting plasma insulin, fasting plasma glucagon-like peptide (GLP)-1 and GLP-2, serum and fecal T-BAs, and gut microbiota were analyzed during the entire course of T2DM development. Results There were reductions in fecal T-BAs and short-chain fatty acids (SCFAs)-producing bacteria including Phascolarctobacterium and Lactobacillus in OLETF rats compared with those in LETO rats at baseline, and low levels of fecal T-BAs and SCFAs-producing bacteria were maintained throughout the whole course of the development of T2DM among OLETF rats compared with those in corresponding age-matched LETO rats. Fecal taurine-conjugated chenodeoxycholic acid correlated positively with Phascolarctobacterium. Fecal taurine-conjugated deoxycholic acid correlated positively with Lactobacillus and fasting plasma GLP-1 and inversely with fasting plasma glucose. Conclusion The fecal BAs profiles and microbiota structure among OLETF rats were different from those of LETO rats during the entire course of T2DM development, indicating that reductions in intestinal T-BAs and specific SCFA-producing bacteria may be potential mechanisms of T2DM in OLETF rats.

scholarly journals Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus

2017 ◽  
Vol 8 (5) ◽  
pp. 661-671 ◽  
Author(s):  
Eri Takahashi ◽  
Hiroyuki Unoki-Kubota ◽  
Yukiko Shimizu ◽  
Tadashi Okamura ◽  
Wakiko Iwata ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Animal Model ◽  
Type 2 Diabetes Mellitus ◽  
Proteomic Analysis ◽  
Serum Biomarkers ◽  
Long Evans ◽  
Spontaneous Animal Model

Influence of piperine and quercetin on antidiabetic potential of curcumin

2016 ◽  
Vol 13 (3) ◽  
Author(s):  
Ginpreet Kaur ◽  
Mihir Invally ◽  
Meena Chintamaneni
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Oral Administration ◽  
Therapeutic Agent ◽  
Therapeutic Potential ◽  
Diabetic Rats ◽  
Reduced Dose ◽  
Single Intraperitoneal Injection

Abstract: Curcumin is a nutraceutical obtained from the rhizomes of: The present study was targeted to explore the antidiabetic potential of combinatorial extract of curcumin with piperine and quercetin (CPQ) in streptozotocin- and nicotinamide-induced diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of streptozotocin (55 mg/kg) and nicotinamide (120 mg/kg: Oral administration of CPQ at the dose of 100 mg kg: Treatment with combinatorial extract of curcumin presented a significantly better therapeutic potential when compared with curcumin alone, which reveals that CPQ, with reduced dose of curcumin may serve as a therapeutic agent in the treatment of type 2 diabetes mellitus.

scholarly journals Insulin and Glucagon Secretions, and Morphological Change of Pancreatic Islets in OLETF Rats, a Model of Type 2 Diabetes Mellitus

2002 ◽  
Vol 17 (1) ◽  
pp. 34 ◽  
Author(s):  
Eun Gyoung Hong ◽  
Hye Lim Noh ◽  
Seong Kyu Lee ◽  
Yoon Sok Chung ◽  
Kwan Woo Lee ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pancreatic Islets ◽  
Morphological Change ◽  
Oletf Rats
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