Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection

2016 ◽  
Vol 7 (7) ◽  
pp. 3211-3223 ◽  
Author(s):  
Arumugam Kamaladevi ◽  
Krishnaswamy Balamurugan
Keyword(s):  
Lactic Acid ◽  
Caenorhabditis Elegans ◽  
Lactic Acid Bacteria ◽  
Klebsiella Pneumoniae ◽  
P38 Mapk ◽  
Lactobacillus Casei ◽  
Molecular Level ◽  
Mapk Pathway ◽  
Model Organism ◽  
P38 Mapk Pathway

In the present study, the effect of lactic acid bacteria was investigated at the molecular level using the model organismCaenorhabditis elegansagainstKlebsiella pneumoniae.

Caenorhabditis elegans mounts a p38 MAPK pathway‐mediated defence to Cutibacterium acnes infection

2020 ◽  
Vol 22 (10) ◽  
Author(s):  
Xiaowen Huang ◽  
Wen Pan ◽  
Wooseong Kim ◽  
Alexis White ◽  
Silei Li ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway ◽  
Cutibacterium Acnes

scholarly journals Cranberry Extract Standardized for Proanthocyanidins Promotes the Immune Response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK Pathway and HSF-1

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103290 ◽  
Author(s):  
Jessica Dinh ◽  
Joseph T. Angeloni ◽  
Daniel B. Pederson ◽  
Xiaoxia Wang ◽  
Min Cao ◽  
...  
Keyword(s):  
Immune Response ◽  
Caenorhabditis Elegans ◽  
Vibrio Cholerae ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway

scholarly journals IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans

2020 ◽  
Vol 11 ◽  
Author(s):  
Cheng-Ju Kuo ◽  
Ya-Chu Hsu ◽  
Sin-Tian Wang ◽  
Bang-Yu Liou ◽  
Serene Boon-Yuean Lim ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Transmembrane Protein ◽  
Host Susceptibility ◽  
Leucine Rich Repeat ◽  
C Elegans ◽  
P38 Mapk Pathway ◽  
Immune Pathway ◽  
Pathogen Avoidance

Enterohemorrhagic Escherichia coli (EHEC), a human pathogen, also infects Caenorhabditis elegans. We demonstrated previously that C. elegans activates the p38 MAPK innate immune pathway to defend against EHEC infection. However, whether a C. elegans pattern recognition receptor (PRR) exists to regulate the immune pathway remains unknown. PRRs identified in other metazoans contain several conserved domains, including the leucine-rich repeat (LRR). By screening a focused RNAi library, we identified the IGLR-2, a transmembrane protein containing the LRR domain, as a potential immune regulator in C. elegans. Our data showed that iglr-2 regulates the host susceptibility to EHEC infection. Moreover, iglr-2 is required for pathogen avoidance to EHEC. The iglr-2 overexpressed strain, which was more resistant to EHEC originally, showed hypersusceptibility to EHEC upon knockdown of the p38 MAPK pathway. Together, our data suggested that iglr-2 plays an important role in C. elegans to defend EHEC by regulating pathogen-avoidance behavior and the p38 MAPK pathway.

Role of the p38 MAPK Pathway in Induction of iNOS Expression in Human Leukocytes

2008 ◽  
Vol 56 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Ewa Jablonska ◽  
Wioletta Ratajczak ◽  
Jakub Jablonski
Keyword(s):  
P38 Mapk ◽  
Mapk Pathway ◽  
Inos Expression ◽  
Human Leukocytes ◽  
P38 Mapk Pathway

Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway

2021 ◽  
Author(s):  
Lingfan Xiong ◽  
Wenhao Guo ◽  
Yong Yang ◽  
Danping Gao ◽  
Jun Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway
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