scholarly journals Protein corona-induced modification of silver nanoparticle aggregation in simulated gastric fluid

2016 ◽  
Vol 3 (6) ◽  
pp. 1510-1520 ◽  
Author(s):  
Andrew P. Ault ◽  
Diana I. Stark ◽  
Jessica L. Axson ◽  
Justin N. Keeney ◽  
Andrew D. Maynard ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Protein Corona ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid ◽  
Nanoparticle Aggregation

This works shows enhanced aggregation of silver nanoparticles in simulated gastric fluid when pepsin protein is present.

scholarly journals Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution

2019 ◽  
Vol 6 (4) ◽  
pp. 1089-1098 ◽  
Author(s):  
Vladimir Gorshkov ◽  
Julia A. Bubis ◽  
Elizaveta M. Solovyeva ◽  
Mikhail V. Gorshkov ◽  
Frank Kjeldsen
Keyword(s):  
Silver Nanoparticles ◽  
Protein Binding ◽  
Blood Plasma ◽  
Silver Nanoparticle ◽  
Protein Corona ◽  
Physicochemical Changes ◽  
Nanoparticle Surface ◽  
Protein Properties ◽  
In Blood Plasma

Highlighted are the protein properties determining protein binding to the silver nanoparticle surface.

scholarly journals Rapid Kinetics of Size and pH-Dependent Dissolution and Aggregation of Silver Nanoparticles in Simulated Gastric Fluid

2015 ◽  
Vol 119 (35) ◽  
pp. 20632-20641 ◽  
Author(s):  
Jessica L. Axson ◽  
Diana I. Stark ◽  
Amy L. Bondy ◽  
Sonja S. Capracotta ◽  
Andrew D. Maynard ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid ◽  
Ph Dependent ◽  
Rapid Kinetics ◽  
Kinetics Of

Human serum albumin stabilizes aqueous silver nanoparticle suspensions and inhibits particle uptake by cells

2018 ◽  
Vol 5 (4) ◽  
pp. 863-867 ◽  
Author(s):  
D. C. Kennedy ◽  
H. Qian ◽  
V. Gies ◽  
L. Yang
Keyword(s):  
Silver Nanoparticles ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Silver Nanoparticle ◽  
Protein Corona ◽  
Particle Uptake ◽  
Nanoparticle Suspensions ◽  
Commercial Polymers ◽  
Better Than

Human serum albumin forms a protein corona that stabilizes silver nanoparticles in water better than commercial polymers.

Emerging investigator series: quantifying silver nanoparticle aggregation kinetics in real-time using particle impact voltammetry coupled with UV-vis spectroscopy

2020 ◽  
Vol 7 (9) ◽  
pp. 2509-2521
Author(s):  
Laela Ezra ◽  
Zachary J. O'Dell ◽  
Janan Hui ◽  
Kathryn R. Riley
Keyword(s):  
Silver Nanoparticles ◽  
Real Time ◽  
Silver Nanoparticle ◽  
Particle Impact ◽  
Aggregation Kinetics ◽  
Nanoparticle Aggregation ◽  
Analytical Technique ◽  
Single Nanoparticle ◽  
Vis Spectroscopy

This work describes the development of an analytical technique that couples single nanoparticle electrochemistry and UV-vis spectroscopy to determine aggregation kinetics and critical coagulation concentrations (CCCs) of silver nanoparticles.

Silver nanoparticle protein corona composition compared across engineered particle properties and environmentally relevant reaction conditions

2014 ◽  
Vol 1 (3) ◽  
pp. 238-247 ◽  
Author(s):  
Richard Eigenheer ◽  
Erick R. Castellanos ◽  
Meagan Y. Nakamoto ◽  
Kyle T. Gerner ◽  
Alyssa M. Lampe ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Surface Engineering ◽  
Protein Corona ◽  
Reaction Conditions ◽  
Biologically Relevant ◽  
Particle Properties ◽  
Nanoparticle Surface

The protein coronas of silver nanoparticles are profoundly impacted by nanoparticle surface engineering and by environmentally and biologically relevant solution conditions.

Pepsin-induced modification of silver nanoparticles in simulated gastric fluid

2021 ◽  
Vol 44 ◽  
pp. 100491
Author(s):  
Tae Hyeon Jeong ◽  
Kyung Bin Kim ◽  
Su Yeon Kim ◽  
Yu Ra Kim ◽  
Jong Hoon Kim ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid

Detection of intracellular silver nanoparticles using flow cytometry

2018 ◽  
pp. 223-226
Author(s):  
С.И. Каба ◽  
А.А. Соколовская
Keyword(s):  
Flow Cytometry ◽  
Silver Nanoparticles ◽  
Endothelial Cells ◽  
Silver Nanoparticle ◽  
Cell Uptake ◽  
Control Samples

Продемонстрировано обнаружение наночастиц серебра во внутриклеточном пространстве с помощью проточной цитофлуориметрии. В эндотелиальных клетках линии EA.hy926, инкубированных в растворе, содержащем 2 мкг/мл наносеребра, измеряли боковое светорассеяние. По сравнению с контрольными образцами этот параметр возрастал, в то время как прочие значимые характеристики не изменялись. Это подтверждает чувствительность метода к изменившемуся состоянию клеток и указывает на поглощение наночастиц серебра клетками при концентрации ниже токсической. The study demonstrated a possibility for detection of intracellular silver nanoparticles using flow cytometry. The parameter used in this work, side scattering, was measured in EA.hy926 endothelial cells incubated in a 2 mg/ml silver nanoparticle solution. This parameter was increased compared to control samples. Therefore, this technique was sensitive to changes in the cell status and suggested the cell uptake of the particles under the subtoxic conditions.

scholarly journals Formulation of Quaternized Aminated Chitosan Nanoparticles for Efficient Encapsulation and Slow Release of Curcumin

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 449
Author(s):  
Ahmed M. Omer ◽  
Zyta M. Ziora ◽  
Tamer M. Tamer ◽  
Randa E. Khalifa ◽  
Mohamed A. Hassan ◽  
...  
Keyword(s):  
Slow Release ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Gastric Fluid ◽  
Release Profile ◽  
Simulated Gastric Fluid ◽  
Maximum Value ◽  
Structure Surface ◽  
Drug Encapsulation Efficiency

An effective drug nanocarrier was developed on the basis of a quaternized aminated chitosan (Q-AmCs) derivative for the efficient encapsulation and slow release of the curcumin (Cur)-drug. A simple ionic gelation method was conducted to formulate Q-AmCs nanoparticles (NPs), using different ratios of sodium tripolyphosphate (TPP) as an ionic crosslinker. Various characterization tools were employed to investigate the structure, surface morphology, and thermal properties of the formulated nanoparticles. The formulated Q-AmCs NPs displayed a smaller particle size of 162 ± 9.10 nm, and higher surface positive charges, with a maximum potential of +48.3 mV, compared to native aminated chitosan (AmCs) NPs (231 ± 7.14 nm, +32.8 mV). The Cur-drug encapsulation efficiency was greatly improved and reached a maximum value of 94.4 ± 0.91%, compared to 75.0 ± 1.13% for AmCs NPs. Moreover, the in vitro Cur-release profile was investigated under the conditions of simulated gastric fluid [SGF; pH 1.2] and simulated colon fluid [SCF; pH 7.4]. For Q-AmCs NPs, the Cur-release rate was meaningfully decreased, and recorded a cumulative release value of 54.0% at pH 7.4, compared to 73.0% for AmCs NPs. The formulated nanoparticles exhibited acceptable biocompatibility and biodegradability. These findings emphasize that Q-AmCs NPs have an outstanding potential for the delivery and slow release of anticancer drugs.

scholarly journals A comparative study of silver nanoparticle dissolution under physiological conditions

2020 ◽  
Vol 2 (12) ◽  
pp. 5760-5768
Author(s):  
Lukas Steinmetz ◽  
Christoph Geers ◽  
Sandor Balog ◽  
Mathias Bonmarin ◽  
Laura Rodriguez-Lorenzo ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Comparative Study ◽  
Silver Nanoparticle ◽  
Biologically Relevant ◽  
Physiological Conditions ◽  
Aggregation Behaviour

The dissolution and aggregation behaviour of silver nanoparticles under physiological conditions and in biologically relevant environments is investigated by exploiting their plasmonic properties.

Modelling inactivation of wild‐type and clinical Escherichia coli O26 strains using UV‐C and thermal treatment and subsequent persistence in simulated gastric fluid

2019 ◽  
Vol 127 (5) ◽  
pp. 1564-1575 ◽  
Author(s):  
V.S. Castro ◽  
D.K.A. Rosario ◽  
Y.S. Mutz ◽  
A.C.C. Paletta ◽  
E.E.S. Figueiredo ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Thermal Treatment ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid ◽  
Wild Type ◽  
Uv C
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