Cargo delivery on demand from photodegradable MOF nano-cages

2017 ◽  
Vol 46 (15) ◽  
pp. 4917-4922 ◽  
Author(s):  
Charity C. Epley ◽  
Kristina L. Roth ◽  
Shaoyang Lin ◽  
Spencer R. Ahrenholtz ◽  
Tijana Z. Grove ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
On Demand ◽  
Cargo Delivery ◽  
Metal Organic ◽  
Organic Framework

The photo-induced degradation of and cargo release from a nanoscale metal–organic framework (nMOF) incorporating photo-isomerizable 4,4′-azobenzenedicarboxylate (AZB) linkers.

On Demand: The Singular rht Net, an Ideal Blueprint for the Construction of a Metal-Organic Framework (MOF) Platform

2012 ◽  
Vol 124 (40) ◽  
pp. 10246-10250 ◽  
Author(s):  
Jarrod F. Eubank ◽  
Farid Nouar ◽  
Ryan Luebke ◽  
Amy J. Cairns ◽  
Lukasz Wojtas ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

On Demand: The Singular rht Net, an Ideal Blueprint for the Construction of a Metal-Organic Framework (MOF) Platform

2012 ◽  
Vol 51 (40) ◽  
pp. 10099-10103 ◽  
Author(s):  
Jarrod F. Eubank ◽  
Farid Nouar ◽  
Ryan Luebke ◽  
Amy J. Cairns ◽  
Lukasz Wojtas ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

On-Demand Degradation of Metal–Organic Framework Based on Photocleavable Dianthracene-Based Ligand

2018 ◽  
Vol 140 (34) ◽  
pp. 10820-10828 ◽  
Author(s):  
Guillaume Collet ◽  
Timothée Lathion ◽  
Céline Besnard ◽  
Claude Piguet ◽  
Stéphane Petoud
Keyword(s):  
Metal Organic Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Junfeng Huang ◽  
Zhourui Xu ◽  
Yihang jiang ◽  
Wing-cheung Law ◽  
Biqin Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Near Infrared ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Zeolitic Imidazolate Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

AbstractChemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Magnetic Ordering via Itinerant Ferromagnetism in a Metal-Organic Framework

2020 ◽  
Author(s):  
Jesse Park ◽  
Brianna Collins ◽  
Lucy Darago ◽  
Tomce Runcevski ◽  
Michael Aubrey ◽  
...  
Keyword(s):  
Charge Transport ◽  
Magnetic Order ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Magnetic Ordering ◽  
Double Exchange ◽  
Itinerant Ferromagnetism ◽  
Organic Solids ◽  
Metal Organic ◽  
Organic Framework

<b>Materials that combine magnetic order with other desirable physical attributes offer to revolutionize our energy landscape. Indeed, such materials could find transformative applications in spintronics, quantum sensing, low-density magnets, and gas separations. As a result, efforts to design multifunctional magnetic materials have recently moved beyond traditional solid-state materials to metal–organic solids. Among these, metal–organic frameworks in particular bear structures that offer intrinsic porosity, vast chemical and structural programmability, and tunability of electronic properties. Nevertheless, magnetic order within metal–organic frameworks has generally been limited to low temperatures, owing largely to challenges in creating strong magnetic exchange in extended metal–organic solids. Here, we employ the phenomenon of itinerant ferromagnetism to realize magnetic ordering at <i>T</i><sub>C</sub> = 225 K in a mixed-valence chromium(II/III) triazolate compound, representing the highest ferromagnetic ordering temperature yet observed in a metal–organic framework. The itinerant ferromagnetism is shown to proceed via a double-exchange mechanism, the first such observation in any metal–organic material. Critically, this mechanism results in variable-temperature conductivity with barrierless charge transport below <i>T</i><sub>C</sub> and a large negative magnetoresistance of 23% at 5 K. These observations suggest applications for double-exchange-based coordination solids in the emergent fields of magnetoelectrics and spintronics. Taken together, the insights gleaned from these results are expected to provide a blueprint for the design and synthesis of porous materials with synergistic high-temperature magnetic and charge transport properties. </b>

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