Fabrication of RGD-conjugated Gd(OH)3:Eu nanorods with enhancement of magnetic resonance, luminescence imaging and in vivo tumor targeting

2016 ◽  
Vol 45 (36) ◽  
pp. 14063-14070 ◽  
Author(s):  
Bianyun Cai ◽  
Zhongbing Huang ◽  
Zhi Wu ◽  
Lei Wang ◽  
Guangfu Yin ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Hydrothermal Method ◽  
Blood Circulation ◽  
Tumor Targeting ◽  
Circulation Time ◽  
Luminescence Imaging

RGD-linked Gd(OH)3:Eu NRs with long blood circulation time were fabricated via a hydrothermal method, PEGylation and thiolation conjugation, and these NRs could enhance in vivo MR and luminescence imagings of gliomas by a good targeting of gliomas.

scholarly journals The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5072
Author(s):  
Xiaodong Li ◽  
Yanhong Sun ◽  
Lina Ma ◽  
Guifeng Liu ◽  
Zhenxin Wang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Blood Circulation ◽  
Time Window ◽  
Circulation Time ◽  
Great Success ◽  
Resonance Imaging ◽  
Enhanced Sensitivity ◽  
Magnetic Resonance Imaging Contrast

The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation.

scholarly journals Polysialic Acid Modified Liposomes for Improving Pharmacokinetics and Overcoming Accelerated Blood Clearance Phenomenon

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 834
Author(s):  
Xi Han ◽  
Ting Zhang ◽  
Mengyang Liu ◽  
Yanzhi Song ◽  
Xinrong Liu ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Polysialic Acid ◽  
Repeated Administration ◽  
The Body ◽  
Circulation Time ◽  
Blood Clearance ◽  
In Vivo Evaluation ◽  
Accelerated Blood Clearance ◽  
Abc Phenomenon

Poly (ethylene glycol) (PEG) modified nanocarriers are being used widely in the drug delivery system (DDS). However, the “accelerated blood clearance (ABC) phenomenon” was induced upon repeated administration of PEG-modified liposomes, resulting in reduced blood circulation time, and increased accumulation in liver and spleen. To avoid the unexpected phenomenon, polysialic acid (PSA) was selected to modify liposomes. PSA is a natural, highly hydrophilic polysaccharide polymer for which no receptors exists in the body. It is non-immunogenic, biodegradable and endows the conjugated bioactive macromolecule and drugs with increased circulation time in vivo. In the present study, the in vivo evaluation showed that PSA modified liposomes (PSA-Lip) afford extended blood circulation in wistar rats and beagle dogs. Moreover, the ABC phenomenon did not occur and the IgM antibody was not induced after repeated injections of PSA-Lip. These results strongly suggest that PSA modification represents a promising strategy to afford good stealth of the liposomes without evoking the ABC phenomenon.

scholarly journals Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

ACS Nano ◽  
2013 ◽  
Vol 7 (10) ◽  
pp. 8870-8880 ◽  
Author(s):  
Christopher E. Nelson ◽  
James R. Kintzing ◽  
Ann Hanna ◽  
Joshua M. Shannon ◽  
Mukesh K. Gupta ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Circulation Time ◽  
Endosome Escape

A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

2005 ◽  
Vol 288-289 ◽  
pp. 163-166 ◽  
Author(s):  
You Rong Duan ◽  
W.S. Liu ◽  
J. Liu ◽  
Z.R. Zhang
Keyword(s):  
Ethylene Glycol ◽  
Blood Circulation ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Systemic Blood ◽  
Model Drug ◽  
Poly Ethylene

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging

2014 ◽  
Vol 53 (18) ◽  
pp. 4551-4555 ◽  
Author(s):  
Jianan Liu ◽  
Jiwen Bu ◽  
Wenbo Bu ◽  
Shengjian Zhang ◽  
Limin Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Drug Release ◽  
Real Time ◽  
Dual Mode ◽  
Luminescence Imaging ◽  
Quantitative Monitoring

scholarly journals A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry: from chemical characterization to in vivo biodistribution

2018 ◽  
Vol 6 (7) ◽  
pp. 1754-1763 ◽  
Author(s):  
Francielle Pelegrin Garcia ◽  
Marlène Rippe ◽  
Mychelle V. P. Companhoni ◽  
Talitha Fernandes Stefanello ◽  
Benoit Louage ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Blood Circulation ◽  
Chemical Characterization ◽  
Circulation Time ◽  
In Vivo Biodistribution ◽  
Tumor Accumulation

Nanogels show long in vivo blood circulation time and high tumor accumulation.

The effect of zwitterionic surface content on blood circulation time of nanocapsule

2020 ◽  
Vol 35 (3) ◽  
pp. 371-384
Author(s):  
Xing Han ◽  
Sidi Li ◽  
Xueping Li ◽  
Qi Zhan ◽  
Yueying Zhan ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Blood Circulation ◽  
Circulation Time ◽  
H Nmr ◽  
Surface Filling ◽  
Optimal Surface ◽  
Delivery Platform ◽  
Surface Content ◽  
The Relationship

Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore the relationship between the zwitterionic content and circulation time of nanocarrier so as to figure out what content of zwitterion can enable the nanocarrier to obtain both the long blood circulation ability and other functions mentioned above. Herein, using nanocapsule as a research model, we investigated the nanocapsule modified with zwitterion of phosphorylcholine (PC) or carboxybetaine (CB) respectively, and through 1H-NMR quantification we determined the zwitterionic surface content, so as to study the effect of PC or CB surface content on blood circulation performance of nanocapsule. In vivo study showed that the nanocapsule possessed an optimal surface filling ratios range for blood circulation of 43–68% for PC and of 20–68% for CB, with the longest t1/2=37.35 h for PC-nanocapsule and t1/2=45.27 h for CB-nanocapsule. Furthermore, the protein adsorption and macrophage endocytosis experiments indicated that when the surface filling ratio reached 43% for PC-nanocapsule and 20% for CB-nanocapsule, it could effectively reduce the protein adsorption and weaken macrophage endocytosis, thus explaining the phenomenon of long circulation time of nanocapsules from the point of protein adsorption and interaction with immune cells. This study proposes a new direction for designing long-circulating nanocarrier, and provides basis for constructing enzyme-responsive and intracellular or extracellular delivery platform.

scholarly journals Extended in vivo blood circulation time of fluorinated liposomes

FEBS Letters ◽  
1993 ◽  
Vol 336 (3) ◽  
pp. 481-484 ◽  
Author(s):  
Catherine Santaella ◽  
Frédéric Frézard ◽  
Pierre Vierling ◽  
Jean G. Riess
Keyword(s):  
Blood Circulation ◽  
Circulation Time

Melanin-manganese nanoparticles with ultrahigh efficient clearance in vivo for tumor-targeting T1 magnetic resonance imaging contrast agent

2018 ◽  
Vol 6 (1) ◽  
pp. 207-215 ◽  
Author(s):  
Wen Xu ◽  
Jinghua Sun ◽  
Liping Li ◽  
Xiaoyang Peng ◽  
Ruiping Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Tumor Targeting ◽  
Resonance Imaging ◽  
Agent Based ◽  
Magnetic Resonance Imaging Contrast ◽  
Imaging Contrast Agent ◽  
Manganese Nanoparticles

A magnetic resonance imaging contrast agent, based on Mn2+-chelating melanin nanoparticles, that has ultrahigh efficient clearance in vivo for tumor-targeted imaging.

scholarly journals Light-Responsive Micelles Loaded With Doxorubicin for Osteosarcoma Suppression

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiayi Chen ◽  
Chenhong Qian ◽  
Peng Ren ◽  
Han Yu ◽  
Xiangjia Kong ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Blood Circulation ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Amide Bond ◽  
Significant Damage ◽  
Stimulus Responsive ◽  
Significant Factors

The enhancement of tumor targeting and cellular uptake of drugs are significant factors in maximizing anticancer therapy and minimizing the side effects of chemotherapeutic drugs. A key challenge remains to explore stimulus-responsive polymeric nanoparticles to achieve efficient drug delivery. In this study, doxorubicin conjugated polymer (Poly-Dox) with light-responsiveness was synthesized, which can self-assemble to form polymeric micelles (Poly-Dox-M) in water. As an inert structure, the polyethylene glycol (PEG) can shield the adsorption of protein and avoid becoming a protein crown in the blood circulation, improving the tumor targeting of drugs and reducing the cardiotoxicity of doxorubicin (Dox). Besides, after ultraviolet irradiation, the amide bond connecting Dox with PEG can be broken, which induced the responsive detachment of PEG and enhanced cellular uptake of Dox. Notably, the results of immunohistochemistry in vivo showed that Poly-Dox-M had no significant damage to normal organs. Meanwhile, they showed efficient tumor-suppressive effects. This nano-delivery system with the light-responsive feature might hold great promises for the targeted therapy for osteosarcoma.

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