Structural and spectroscopic insight into the metal binding properties of the o-aminophenol-N,N,O-triacetic acid (APTRA) chelator: implications for design of metal indicators

2016 ◽  
Vol 45 (31) ◽  
pp. 12458-12464 ◽  
Author(s):  
Michael Brady ◽  
Sebastian D. Piombo ◽  
Chunhua Hu ◽  
Daniela Buccella
Keyword(s):  
Metal Binding ◽  
Binding Properties ◽  
Coordination Properties ◽  
Weak Binding ◽  
Recognition Motifs ◽  
Metal Recognition ◽  
Insight Into ◽  
Enhanced Selectivity

Studies on the coordination properties of APTRA reveal the origin of weak binding to Mg2+, and provide clues for design of metal-recognition motifs with enhanced selectivity for applications in sensing.

scholarly journals Differential metal-binding properties of dynamic acylhydrazone polymers and their sensing applications

2017 ◽  
Vol 4 (8) ◽  
pp. 170466 ◽  
Author(s):  
Siheng Gao ◽  
Lijie Li ◽  
Ismail Vohra ◽  
Daijun Zha ◽  
Lei You
Keyword(s):  
Metal Binding ◽  
Binding Properties ◽  
Covalent Bonds ◽  
Responsive Materials ◽  
Metal Binding Sites ◽  
Sensing Applications ◽  
Sensitivity And Selectivity ◽  
Application Potential ◽  
Metal Recognition ◽  
Fine Tune

As one of common dynamic covalent bonds, acylhydrazone bond plays an important role in developing intelligent responsive materials. In this report, we present acylhydrazone-based dynamic polymers with multi-stimuli responsiveness, particularly metal recognition behaviours and their modulation. A series of polyacylhydrazones with different metal-binding sites were designed and prepared in a modular fashion. Titration of these receptors with a diverse set of metal ions, including Cu 2+ , Zn 2+ and La 3+ , resulted in unique optical changes, and both the sensitivity and selectivity profiles can be regulated. Moreover, the metal-binding feature was facilely modulated by changing the solvent. The addition of weakly basic anions was employed to further fine-tune the responsiveness of the polymers by taking advantage of the cooperative effect with metal coordination. Finally, the sensitive detection of 6-mercaptopurine and pyrophosphate was achieved to demonstrate the application potential of these systems.

A new family of fluorescent calcium indicators designed to resist leakage or for measuring calcium near membranes

1994 ◽  
Vol 52 ◽  
pp. 168-169
Author(s):  
Martin Poenie ◽  
Akwasi Minta ◽  
Charles Vorndran
Keyword(s):  
Metal Binding ◽  
Acetoxymethyl Ester ◽  
Binding Properties ◽  
Fura 2 ◽  
New Family ◽  
Anion Transporter ◽  
Calcium Indicator ◽  
Calcium Indicators ◽  
High Calcium ◽  
Intracellular Compartmentalization

The use of fura-2 as an intracellular calcium indicator is complicated by problems of rapid dye leakage and intracellular compartmentalization which is due to a probenecid sensitive anion transporter. In addition there is increasing evidence for localized microdomains of high calcium signals which may not be faithfully reported by fura-2.We have developed a new family of fura-2 analogs aimed at addressing some of these problems. These new indicators are based on a modified bapta which can be readily derivatized to produce fura-2 analogs with a variety of new properties. The modifications do not affect the chromophore and have little impact on the spectral and metal binding properties of the indicator. One of these new derivatives known as FPE3 is a zwitterionic analog of fura-2 that can be loaded into cells as an acetoxymethyl ester and whose retention in cells is much improved. The improved retention of FPE3 is important for both cuvettebased measurements of cell suspensions and for calcium imaging.

Synthesis and Metal-Binding Properties of Chelating Fluorescein Derivatives

2003 ◽  
Vol 5 (12) ◽  
pp. 2051-2054 ◽  
Author(s):  
Matthew A. Clark ◽  
Kathryn Duffy ◽  
Jyoti Tibrewala ◽  
Stephen J. Lippard
Keyword(s):  
Metal Binding ◽  
Binding Properties

Synthesis and metal binding properties of the novel ligand N,N′N″-tris(2-hydroxyethyl)-1,4,7-triazacyclononane

1983 ◽  
Vol 77 ◽  
pp. L63-L64 ◽  
Author(s):  
Bridget A. Sayer ◽  
Joseph P. Michael ◽  
Robert D. Hancock
Keyword(s):  
Metal Binding ◽  
The Novel ◽  
Binding Properties

scholarly journals Cucumber Metallothionein-Like 2 (CsMTL2) Exhibits Metal-Binding Properties

Genes ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 106 ◽  
Author(s):  
Yu Pan ◽  
Yanglu Pan ◽  
Junpeng Zhai ◽  
Yan Xiong ◽  
Jinhua Li ◽  
...  
Keyword(s):  
Metal Binding ◽  
Binding Properties
Sign in / Sign up

Export Citation Format

Share Document