Dehydrogenative coupling promoted by copper catalysts: a way to optimise and upgrade bio-alcohols

2017 ◽  
Vol 7 (6) ◽  
pp. 1386-1393 ◽  
Author(s):  
Nicola Scotti ◽  
Federica Zaccheria ◽  
Claudio Evangelisti ◽  
Rinaldo Psaro ◽  
Nicoletta Ravasio
Keyword(s):  
Copper Catalysts ◽  
One Pot ◽  
Excellent Yield ◽  
Dehydrogenative Coupling ◽  
One Step

A one-pot one-step transformation of butanol into butyl butanoate takes place with excellent yield on a Cu/ZrO2 catalyst.

scholarly journals Dehydrogenative Coupling of Methanol for the Gas-Phase, One-Step Synthesis of Dimethoxymethane over Supported Copper Catalysts

2020 ◽  
Vol 8 (32) ◽  
pp. 12151-12160
Author(s):  
Anh The To ◽  
Trenton J. Wilke ◽  
Eric Nelson ◽  
Connor P. Nash ◽  
Andrew Bartling ◽  
...  
Keyword(s):  
Gas Phase ◽  
Copper Catalysts ◽  
Dehydrogenative Coupling ◽  
One Step ◽  
Supported Copper Catalysts

The one-step transformation of fructose to 2,5-diformylfuran over Ru metal supported on montmorillonite

2020 ◽  
Vol 44 (32) ◽  
pp. 13659-13668
Author(s):  
Amol B. Raut ◽  
Vaishali S. Shende ◽  
Bhalchandra M. Bhanage
Keyword(s):  
One Pot ◽  
Excellent Yield ◽  
One Step ◽  
The One

Ruthenium metal supported on a montmorillonite (2 wt% Ru-MMT) catalyst have been synthesized and characterized. Catalyst found to be effective for the one-pot transformation of fructose to DFF showing an excellent yield with good recyclability.

A Study on the Rearrangement of Dialkyl 1-Aryl-1-hydroxymethylphosphonates to Benzyl Phosphates

2020 ◽  
Vol 24 (4) ◽  
pp. 465-471 ◽  
Author(s):  
Zita Rádai ◽  
Réka Szabó ◽  
Áron Szigetvári ◽  
Nóra Zsuzsa Kiss ◽  
Zoltán Mucsi ◽  
...  
Keyword(s):  
Quantum Chemical ◽  
Room Temperature ◽  
Phase Transfer ◽  
One Pot ◽  
Substrate Dependence ◽  
Triethylbenzylammonium Chloride ◽  
One Step ◽  
The Pudovik Reaction ◽  
The One ◽  
Solid Liquid

The phospha-Brook rearrangement of dialkyl 1-aryl-1-hydroxymethylphosphonates (HPs) to the corresponding benzyl phosphates (BPs) has been elaborated under solid-liquid phase transfer catalytic conditions. The best procedure involved the use of triethylbenzylammonium chloride as the catalyst and Cs2CO3 as the base in acetonitrile as the solvent at room temperature. The substrate dependence of the rearrangement has been studied, and the mechanism of the transformation under discussion was explored by quantum chemical calculations. The key intermediate is an oxaphosphirane. The one-pot version starting with the Pudovik reaction has also been developed. The conditions of this tandem transformation were the same, as those for the one-step HP→BP conversion.

Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

2019 ◽  
Vol 55 (82) ◽  
pp. 12384-12387 ◽  
Author(s):  
Yanling Zheng ◽  
Xufeng Nie ◽  
Yang Long ◽  
Li Ji ◽  
Haiyan Fu ◽  
...  
Keyword(s):  
Phosphine Ligand ◽  
Primary Amines ◽  
Dehydrogenative Coupling ◽  
One Step

The first synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene–phosphine–phosphine ligand as the catalyst.

Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction

2016 ◽  
Vol 40 (12) ◽  
pp. 10412-10417 ◽  
Author(s):  
Chetan K. Khatri ◽  
Deelip S. Rekunge ◽  
Ganesh U. Chaturbhuj
Keyword(s):  
Biginelli Reaction ◽  
Solvent Free ◽  
Synthetic Methodology ◽  
One Pot ◽  
Free Condition ◽  
Sulfated Polyborate ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Solvent Free Condition

A highly efficient and improved synthetic methodology for the preparation of 3,4-dihydropyrimidin-2(1H)-one derivatives in good to excellent yield via Biginelli reaction of β-ketoesters/β-diketone, urea/thiourea and various aldehydes using new, efficient and recyclable sulfated polyborate catalyst under the solvent-free condition is reported.

scholarly journals Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles

2018 ◽  
Vol 14 ◽  
pp. 2789-2798 ◽  
Author(s):  
Camila S Pires ◽  
Daniela H de Oliveira ◽  
Maria R B Pontel ◽  
Jean C Kazmierczak ◽  
Roberta Cargnelutti ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Functional Group ◽  
Diazo Compound ◽  
Molecular Iodine ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
X Ray ◽  
Dehydrogenative Coupling ◽  
Reflux Temperature

A one-pot iodine-catalyzed multicomponent reaction has been developed for the selective preparation of 5-amino-4-(arylselanyl)-1H-pyrazoles from a diverse array of benzoylacetonitriles, arylhydrazines and diaryl diselenides. The reactions were conducted in MeCN as solvent at reflux temperature under air. The methodology presents a large functional group tolerance to electron-deficient, electron-rich, and bulky substituents and gave the expected products in good to excellent yields. The synthesized 1,3-diphenyl-4-(phenylselanyl)-1H-pyrazol-5-amine was submitted to an oxidative dehydrogenative coupling to produce a diazo compound confirmed by X-ray analysis.

scholarly journals Microwave-Assisted Vacuum Synthesis of TiO2 Nanocrystalline Powders in One-Pot, One-Step Procedure

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 149
Author(s):  
Enrico Paradisi ◽  
Roberto Rosa ◽  
Giovanni Baldi ◽  
Valentina Dami ◽  
Andrea Cioni ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Sol Gel ◽  
Reaction Medium ◽  
Process Intensification ◽  
Nanocrystalline Powders ◽  
Fast Heating ◽  
One Pot ◽  
Nanoparticle Suspension ◽  
Step Procedure ◽  
One Step

A new method for fast and simple synthesis of crystalline TiO2 nanoparticles with photocatalytic activity was developed by carrying out a classic sol–gel reaction directly under vacuum. The use of microwaves for fast heating of the reaction medium further reduces synthesis times. When the solvent is completely removed by vacuum, the product is obtained in the form of a powder that can be easily redispersed in water to yield a stable nanoparticle suspension, exhibiting a comparable photocatalytic activity with respect to a commercial product. The present methodology can, therefore, be considered a process intensification procedure for the production of nanotitania.

scholarly journals Expedient Microwave-Assisted Synthesis of Bis(n)-lophine Analogues as Selective Butyrylcholinesterase Inhibitors: Cytotoxicity Evaluation and Molecular Modelling

2021 ◽  
Author(s):  
Viktor Câmara ◽  
Ana Julia Soares ◽  
Brunella Biscussi ◽  
Ana Paula Murray ◽  
Isabella Guedes ◽  
...  
Keyword(s):  
Ammonium Acetate ◽  
Docking Studies ◽  
Microwave Assisted Synthesis ◽  
One Pot ◽  
Cytotoxic Effects ◽  
One Step ◽  
The Brain ◽  
Micromolar Range ◽  
Potent Inhibitory Activity

In the brain of patients with chronic Alzheimer’s disease (AD), the butyrylcholinesterase (BuChE) levels rise while the acetylcholinesterase (AChE) levels decrease. Therefore, development of new selective BuChE inhibitors is of vital importance. Here we present a series of bis(n)‑lophine analogues, where two lophine derivatives are connected by a methylene chain. The bis(n)-lophine analogues were synthesized through one-pot four component reaction between pyridinecarboxaldehydes, 1,n-alkanediamines, benzil, and ammonium acetate. The reactions were performed in a microwave reactor in one step for symmetrical bis(n)-lophines, and in two steps for unsymmetrical bis(n)-lophines. The compounds are strongly selective to BuChE, since none of them inhibit AChE. All the compounds, except 7a, 7b and 7c, displayed potent inhibitory activity against BuChE at a micromolar and sub-micromolar range (half maximal inhibitory concentration (IC50) 32.25-0.03 μM). The enzyme kinetic and docking studies suggests that the inhibitor act as a dual binding site inhibitor, binding into the bottom of the gorge and in the peripheral anionic site (PAS) of BuChE cavity. Furthermore, in vitro studies showed that compounds 5b and 12b had no cytotoxic effects in kidney Vero, hepatic HepG2 and C6 astroglial cell lines.

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