The reaction mechanism of sarcosine oxidase elucidated using FMO and QM/MM methods

2017 ◽  
Vol 19 (15) ◽  
pp. 9811-9822 ◽  
Author(s):  
Yukihiro Abe ◽  
Mitsuo Shoji ◽  
Yoshiaki Nishiya ◽  
Hiroshi Aiba ◽  
Takahide Kishimoto ◽  
...  

Monomeric sarcosine oxidase (MSOX) is a flavoprotein that oxidizes sarcosine to the corresponding imine product and is widely used in clinical diagnostics to test renal function.

2020 ◽  
Vol 22 (29) ◽  
pp. 16552-16561
Author(s):  
Mitsuo Shoji ◽  
Yukihiro Abe ◽  
Mauro Boero ◽  
Yasuteru Shigeta ◽  
Yoshiaki Nishiya

Reaction mechanism of monomeric sarcosine oxidase (MSOX) with N-cyclopropylglycine (CPG) is unravelled at the theoretical level of the hybrid quantum mechanics/molecular mechanical (QM/MM) method.


Author(s):  
Tomasz J. Idzik ◽  
Zofia M. Myk ◽  
Łukasz Struk ◽  
Magdalena Perużyńska ◽  
Gabriela Maciejewska ◽  
...  

Triisopropylsilyltrifluoromethanesulfonate can be effectively used for the arylation of a wide range of enelactams. The multinuclear NMR study provided deep insights into the reaction mechanism.


2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  

2007 ◽  
Vol 177 (4S) ◽  
pp. 542-543
Author(s):  
Rajash K. Handa ◽  
Lynn R. Willis ◽  
Andrew P. Evan ◽  
Bret A. Connors ◽  
Ryan F. Paterson ◽  
...  
Keyword(s):  

2007 ◽  
Vol 177 (4S) ◽  
pp. 593-594
Author(s):  
Shelby N. Morrisroe ◽  
Erin P. Gibbons ◽  
Benjamin R. Stockton ◽  
Kyongtae T. Bae ◽  
Cheng Hong ◽  
...  

2006 ◽  
Vol 175 (4S) ◽  
pp. 282-283
Author(s):  
Shigeta Masanobu ◽  
Koji Mita ◽  
Tsuguru Usui ◽  
Kazushi Marukawa ◽  
Toshihiro Tachikake

2006 ◽  
Vol 175 (4S) ◽  
pp. 245-245
Author(s):  
Joao L. Pippi Salle ◽  
Anthony J. Cook ◽  
Frank Papanicolaou ◽  
Darius J. Bagli ◽  
Farhat Walid ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 503-503
Author(s):  
Boaz Moskovitz ◽  
Vladimir Sopov ◽  
Sarel Halachmi ◽  
Michael Mullerad ◽  
Yusef Barbara ◽  
...  

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