Kinetics of prebiotic depsipeptide formation from the ester–amide exchange reaction

2016 ◽  
Vol 18 (41) ◽  
pp. 28441-28450 ◽  
Author(s):  
Sheng-Sheng Yu ◽  
Ramanarayanan Krishnamurthy ◽  
Facundo M. Fernández ◽  
Nicholas V. Hud ◽  
F. Joseph Schork ◽  
...  
Keyword(s):  
Kinetic Model ◽  
Exchange Reaction ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Amide Exchange ◽  
Kinetics Of

In this work, we introduce a kinetic model to study the effectiveness of ester-mediated amide bond formation under prebiotic conditions.

The effect of temperature on the kinetics of enhanced amide bond formation from lactic acid and valine driven by deep eutectic solvents

2021 ◽  
Author(s):  
Yi-Ting Tsai ◽  
Cong-Wei Huang ◽  
Sheng-Sheng Yu
Keyword(s):  
Amino Acids ◽  
Lactic Acid ◽  
Bond Formation ◽  
Deep Eutectic Solvents ◽  
Amide Bond ◽  
Effect Of Temperature ◽  
Hydroxy Acids ◽  
Amide Bond Formation ◽  
Amide Exchange ◽  
Kinetics Of

Deep eutectic solvents have been found to facilitate the copolymerization of hydroxy acids and amino acids through ester-amide exchange reaction, and to drive the formation of amino acid-enriched oligomers with...

Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

2018 ◽  
Vol 16 (1) ◽  
pp. 30-33
Author(s):  
Ashish Kumar ◽  
Yahya E. Jad ◽  
Ayman El-Faham ◽  
Beatriz G. de la Torre ◽  
Fernando Albericio
Keyword(s):  
Bond Formation ◽  
Hydrolytic Stability ◽  
Solid Material ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

A Review of Amide Bond Formation in Microwave Organic Synthesis

2014 ◽  
Vol 11 (4) ◽  
pp. 592-604 ◽  
Author(s):  
Natalia Lukasik ◽  
Ewa Wagner-Wysiecka
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines

2017 ◽  
Vol 15 (30) ◽  
pp. 6367-6374 ◽  
Author(s):  
Song-Lin Zhang ◽  
Hai-Xing Wan ◽  
Zhu-Qin Deng
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Computational Study ◽  
Bond Formation ◽  
Amide Bond ◽  
Reactivity Pattern ◽  
Amide Bond Formation ◽  
Coupling Reagent ◽  
Catalytic Effects ◽  
Acid Substrate

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

Green Amide Bond Formation in Water via Direct Coupling of Metal Carboxylate Salts with Ammonium Salts at Room Temperature

2021 ◽  
Author(s):  
Truong Thanh Tung ◽  
John Nielsen
Keyword(s):  
Room Temperature ◽  
Bond Formation ◽  
Direct Coupling ◽  
Ammonium Salts ◽  
Amide Bond ◽  
Metal Carboxylate ◽  
Amide Bond Formation ◽  
Simple Protocol

Herein, we report the green, expedite, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary...

Mechanism of Amide Bond Formation from Carboxylic Acids and Amines Promoted by 9-Silafluorenyl Dichloride Derivatives

2017 ◽  
Vol 82 (17) ◽  
pp. 9087-9096 ◽  
Author(s):  
Yuan-Ye Jiang ◽  
Ling Zhu ◽  
Yujie Liang ◽  
Xiaoping Man ◽  
Siwei Bi
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation
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