Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces

2016 ◽  
Vol 18 (38) ◽  
pp. 26630-26642 ◽  
Author(s):  
Debby P. Chang ◽  
Aleksandra P. Dabkowska ◽  
Richard A. Campbell ◽  
Maria Wadsäter ◽  
Justas Barauskas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystalline ◽  
Interfacial Properties ◽  
High Potential ◽  
Silica Surfaces ◽  
Drug Molecules ◽  
Hydrophilic Drug ◽  
Liquid Crystalline Nanoparticles ◽  
Drug Delivery Applications

Reversed lipid liquid crystalline nanoparticles (LCNPs) of the cubic micellar (I2) phase have high potential in drug delivery applications due to their ability to encapsulate both hydrophobic and hydrophilic drug molecules.

Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Sara Yazdani ◽  
Seyed Mohammad Ghoreishi ◽  
Neda Habibi
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Amino Acid Sequences ◽  
Molecular Structures ◽  
Flufenamic Acid ◽  
Mixture Ratio ◽  
Drug Molecules ◽  
Release Capacity ◽  
Essential Properties ◽  
Drug Delivery Applications

Background: Due to their solid-like porous structure, molecular organogel and microcrystal structures have the capabilities of loading drug molecules, encapsulation, and extended release, all considered as essential properties in drug delivery applications. Phases of these structures, however, depend on the solvent used during the gelation process. Objective: Understanding the phase transition between organogel and microcrystal structures through adjusting the mixture ratio of different co-solvents. Method: Short peptide Diphenylalanine as the gelation building block was used due to its amino acid sequences that can be exactly selected at its molecular levels. Ethanol as a polar solvent was used in combination with four other co-solvents with different polarity levels, namely Xylene, Toluene, Acetone, and Dimethyl Sulfoxide. The morphology of molecular structures of each co-solvent combination at each ratio level was examined as well as the loading and release properties for a non-polar Flufenamic Acid drug. Results: The resultant structure wasaffected by the polarity of the co-solvents; in particular, in the sample containing 25 μg/ml of the drug, 94% of the drug amount was loaded inside the organogel. By increasing the drug concentration to 50, 75, and 100 μg/ml, the loading capability decreased to 76%, 47%, and 33%, respectively. Conclusion: Molecular organogels have excellent capabilities of loading drug molecules, while microcrystal structures have higher release capacity. The findings of this study reveal how to best design a gelation method to obtain maximum loading or release properties for a particular peptide-based drug delivery application.

Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems

2019 ◽  
Vol 24 (7) ◽  
pp. 1405-1412 ◽  
Author(s):  
Thiagarajan Madheswaran ◽  
Murugesh Kandasamy ◽  
Rajendran JC Bose ◽  
Vengadeshprabhu Karuppagounder
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Liquid Crystalline ◽  
Delivery Systems ◽  
Liquid Crystalline Nanoparticles ◽  
Current Potential

scholarly journals Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 16 ◽  
Author(s):  
Anan Yaghmur ◽  
Boi Vi Tran ◽  
Seyed Moein Moghimi
Keyword(s):  
Liquid Crystalline ◽  
Drug Carriers ◽  
Structural Features ◽  
Drug Induced ◽  
Guest Molecules ◽  
Drug Molecules ◽  
Liquid Crystalline Nanoparticles ◽  
The Mean ◽  
Biological Performance ◽  
Glycerol Monooleate

Owing to their unique structural features, non-lamellar liquid crystalline nanoparticles comprising cubosomes and hexosomes are attracting increasing attention as versatile investigative drug carriers. Background: Depending on their physiochemical characteristics, drug molecules on entrapment can modulate and reorganize structural features of cubosomes and hexosomes. Therefore, it is important to assess the effect of guest molecules on broader biophysical characteristics of non-lamellar liquid crystalline nanoparticles, since drug-induced architectural, morphological, and size modifications can affect the biological performance of cubosomes and hexosomes. Methods: We report on alterations in morphological, structural, and size characteristics of nanodispersions composed from binary mixtures of glycerol monooleate and vitamin E on thymoquinone (a molecule with wide therapeutic potentials) loading. Results: Thymoquinone loading was associated with a slight increase in the mean hydrodynamic nanoparticle size and led to structural transitions from an internal biphasic feature of coexisting inverse cubic Fd3m and hexagonal (H2) phases to an internal inverse cubic Fd3m phase (micellar cubosomes) or an internal inverse micellar (L2) phase (emulsified microemulsions, EMEs). We further report on the presence of “flower-like” vesicular populations in both native and drug-loaded nanodispersions. Conclusions: These nanodispersions have the potential to accommodate thymoquinone and may be considered as promising platforms for the development of thymoquinone nanomedicines.

Graphene nano-ribbon based high potential and efficiency for DNA, cancer therapy and drug delivery applications

2019 ◽  
Vol 51 (1) ◽  
pp. 91-104 ◽  
Author(s):  
Seyyed Mojtaba Mousavi ◽  
Sadaf Soroshnia ◽  
Seyyed Alireza Hashemi ◽  
Aziz Babapoor ◽  
Younes Ghasemi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
High Potential ◽  
Drug Delivery Applications

A Review of Basics and Potential of Liquid Crystalline Nanoparticles as Drug Delivery Systems

2021 ◽  
Vol 11 ◽  
Author(s):  
Mangesh Pradeep Kulkarni ◽  
Poluri Sesha Sai Kiran ◽  
Kamaldeep Singh ◽  
Kamal Dua ◽  
Sagar Tanwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystals ◽  
Liquid Crystalline ◽  
Structural Alignment ◽  
Physical Parameters ◽  
Stable Form ◽  
Theranostic Agent ◽  
Self Assembling ◽  
Liquid Crystalline Nanoparticles ◽  
Made In

Aim: For procuring the stable form of drug delivery, tremendous efforts have been made in developing new drug delivery vectors. One such approach that meets the desired stability standards is Liquid Crystalline Nanoparticles (LCNs). Background: The liquid crystals are the intermediate forms of solid and liquid materials, which hold high tolerance to bear the influences of physical parameters. The liquid crystals are employed in nanotechnology to find the best way to produce the intended action of customized targeting drug delivery. The structural alignment is another critical aspect to consider, as these can accommodate wholesome drug amounts. Methods: From the studies, it has been evident that distinct characteristics like the simplicity in structure, self-assembling properties, feasibility of production, efficacy in delivery with low toxic values, have addressed the excellency of LCNs. Conclusion: The current review focusses on key areas regarding the nature of liquid crystal, diverse forms, technologies used to transform them into the desired nanoparticles, and their applications as drug delivery carriers as well as theranostic agent.

Physicochemical and Drug Delivery Aspects of Lipid-Based Liquid Crystalline Nanoparticles: A Case Study of Intravenously Administered Propofol

2006 ◽  
Vol 6 (9) ◽  
pp. 3017-3024 ◽  
Author(s):  
Markus Johnsson ◽  
Justas Barauskas ◽  
Andreas Norlin ◽  
Fredrik Tiberg
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Drug Loading ◽  
Drug Substances ◽  
Physicochemical Features ◽  
Liquid Crystalline Nanoparticles ◽  
Effect Duration

Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including: higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration.

scholarly journals Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies

Nanoscale ◽  
2015 ◽  
Vol 7 (9) ◽  
pp. 3817-3837 ◽  
Author(s):  
Mijanur Rahaman Molla ◽  
Poornima Rangadurai ◽  
Giovanni M. Pavan ◽  
S. Thayumanavan
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Macromolecular Assemblies ◽  
Drug Molecules ◽  
Theoretical Investigations ◽  
Drug Delivery Applications

Stimuli-responsive macromolecular assemblies are of great interest in drug delivery applications, as it holds the promise to keep the drug molecules sequestered under one set of conditions and release them under another.

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