scholarly journals 35Cl dynamic nuclear polarization solid-state NMR of active pharmaceutical ingredients

2016 ◽  
Vol 18 (37) ◽  
pp. 25893-25904 ◽  
Author(s):  
David A. Hirsh ◽  
Aaron J. Rossini ◽  
Lyndon Emsley ◽  
Robert W. Schurko
Keyword(s):  
Solid State ◽  
Dynamic Nuclear Polarization ◽  
Solid State Nmr ◽  
Nuclear Polarization ◽  
Molecular Level ◽  
Level Structure ◽  
Dosage Forms ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

In this work, we show how to obtain efficient dynamic nuclear polarization (DNP) enhanced 35Cl solid-state NMR (SSNMR) spectra at 9.4 T and demonstrate how they can be used to characterize the molecular-level structure of hydrochloride salts of active pharmaceutical ingredients (APIs) in both bulk and low wt% API dosage forms.

scholarly journals Dynamic Nuclear Polarization / solid-state NMR of membranes. Thermal effects and sample geometry

2019 ◽  
Vol 100 ◽  
pp. 70-76 ◽  
Author(s):  
Evgeniy Sergeevich Salnikov ◽  
Fabien Aussenac ◽  
Sebastian Abel ◽  
Armin Purea ◽  
Paul Tordo ◽  
...  
Keyword(s):  
Solid State ◽  
Dynamic Nuclear Polarization ◽  
Thermal Effects ◽  
Solid State Nmr ◽  
Nuclear Polarization ◽  
Sample Geometry

scholarly journals Solid-State NMR/Dynamic Nuclear Polarization of Polypeptides in Planar Supported Lipid Bilayers

2015 ◽  
Vol 119 (46) ◽  
pp. 14574-14583 ◽  
Author(s):  
Evgeniy S. Salnikov ◽  
Hiba Sarrouj ◽  
Christian Reiter ◽  
Christopher Aisenbrey ◽  
Armin Purea ◽  
...  
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Dynamic Nuclear Polarization ◽  
Solid State Nmr ◽  
Nuclear Polarization ◽  
Supported Lipid Bilayers

scholarly journals Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology

2013 ◽  
Vol 56 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Ioannis Gelis ◽  
Veronika Vitzthum ◽  
Neha Dhimole ◽  
Marc A. Caporini ◽  
Andreas Schedlbauer ◽  
...  
Keyword(s):  
Solid State ◽  
Structural Biology ◽  
Dynamic Nuclear Polarization ◽  
Solid State Nmr ◽  
Nuclear Polarization

Up to 100% Improvement in Dynamic Nuclear Polarization Solid-State NMR Sensitivity Enhancement of Polymers by Removing Oxygen

2015 ◽  
Vol 36 (15) ◽  
pp. 1416-1421 ◽  
Author(s):  
Dao Le ◽  
Fabio Ziarelli ◽  
Trang N. T. Phan ◽  
Giulia Mollica ◽  
Pierre Thureau ◽  
...  
Keyword(s):  
Solid State ◽  
Dynamic Nuclear Polarization ◽  
Solid State Nmr ◽  
Nuclear Polarization ◽  
Sensitivity Enhancement ◽  
Nmr Sensitivity

scholarly journals Improved Structural Elucidation of Synthetic Polymers by Dynamic Nuclear Polarization Solid-State NMR Spectroscopy

2013 ◽  
Vol 2 (8) ◽  
pp. 715-719 ◽  
Author(s):  
Olivier Ouari ◽  
Trang Phan ◽  
Fabio Ziarelli ◽  
Gilles Casano ◽  
Fabien Aussenac ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Dynamic Nuclear Polarization ◽  
Solid State Nmr ◽  
Nuclear Polarization ◽  
Synthetic Polymers ◽  
Structural Elucidation ◽  
Solid State Nmr Spectroscopy

35Cl solid-state NMR of HCl salts of active pharmaceutical ingredients: structural prediction, spectral fingerprinting and polymorph recognition

CrystEngComm ◽  
2014 ◽  
Vol 16 (31) ◽  
pp. 7334-7356 ◽  
Author(s):  
Marcel Hildebrand ◽  
Hiyam Hamaed ◽  
Andrew M. Namespetra ◽  
John M. Donohue ◽  
Riqiang Fu ◽  
...  
Keyword(s):  
Solid State ◽  
Plane Wave ◽  
Dft Calculations ◽  
First Principles ◽  
Solid State Nmr ◽  
Active Pharmaceutical Ingredients ◽  
Structural Prediction ◽  
Pharmaceutical Ingredients

A series of HCl salts of active pharmaceutical ingredients (APIs) have been characterized via35Cl solid-state NMR (SSNMR) spectroscopy and first-principles plane-wave DFT calculations of 35Cl NMR interaction tensors.

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