Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

2016 ◽  
Vol 18 (28) ◽  
pp. 18923-18933 ◽  
Author(s):  
Tongtao Yue ◽  
Yan Xu ◽  
Shixin Li ◽  
Xianren Zhang ◽  
Fang Huang
Keyword(s):  
Pulmonary Surfactant ◽  
Lipid Extraction ◽  
Md Simulations ◽  
Carbon Nanospheres ◽  
Surfactant Monolayers ◽  
Size Dependent

Our MD simulations demonstrate that the aggregation of carbon nanospheres in PSM is in fact size-dependent and mediated by lipid extractions.

scholarly journals Simulated Breathing: Application of Molecular Dynamics Simulations to Pulmonary Lung Surfactant

Symmetry ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1259
Author(s):  
Maksymilian Dziura ◽  
Basel Mansour ◽  
Mitchell DiPasquale ◽  
P. Charukeshi Chandrasekera ◽  
James W. Gauld ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Pulmonary Surfactant ◽  
Lung Surfactant ◽  
Protein Composition ◽  
Md Simulations ◽  
Building Blocks ◽  
Future Research ◽  
Total Composition ◽  
Protein Components ◽  
Dynamics Simulations

In this review, we delve into the topic of the pulmonary surfactant (PS) system, which is present in the respiratory system. The total composition of the PS has been presented and explored, from the types of cells involved in its synthesis and secretion, down to the specific building blocks used, such as the various lipid and protein components. The lipid and protein composition varies across species and between individuals, but ultimately produces a PS monolayer with the same role. As such, the composition has been investigated for the ways in which it imposes function and confers peculiar biophysical characteristics to the system as a whole. Moreover, a couple of theories/models that are associated with the functions of PS have been addressed. Finally, molecular dynamic (MD) simulations of pulmonary surfactant have been emphasized to not only showcase various group’s findings, but also to demonstrate the validity and importance that MD simulations can have in future research exploring the PS monolayer system.

scholarly journals Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung-specific additives

2017 ◽  
Vol 49 (9) ◽  
pp. 864-872
Author(s):  
Michael J. Davies ◽  
Zoe Taylor ◽  
Andrew G. Leach ◽  
James Ren ◽  
Paul Gibbons
Keyword(s):  
Pulmonary Surfactant ◽  
Surfactant Monolayers

scholarly journals The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions

2017 ◽  
Vol 49 (7) ◽  
pp. 654-665 ◽  
Author(s):  
Michael J. Davies ◽  
Jason W. Birkett ◽  
Mateusz Kotwa ◽  
Lauren Tomlinson ◽  
Rezene Woldetinsae
Keyword(s):  
Pulmonary Surfactant ◽  
Surfactant Monolayers ◽  
The Impact

scholarly journals Effects of Hydrophobic Surfactant Proteins on Collapse of Pulmonary Surfactant Monolayers

2007 ◽  
Vol 93 (12) ◽  
pp. 4237-4243 ◽  
Author(s):  
Florence Lhert ◽  
Wenfei Yan ◽  
Samares C. Biswas ◽  
Stephen B. Hall
Keyword(s):  
Pulmonary Surfactant ◽  
Surfactant Proteins ◽  
Surfactant Monolayers

The crystal engineering of salbutamol sulphate via simulated pulmonary surfactant monolayers

2013 ◽  
Vol 446 (1-2) ◽  
pp. 34-45 ◽  
Author(s):  
Michael J. Davies ◽  
Thomas D. Kerry ◽  
Linda Seton ◽  
Mark F. Murphy ◽  
Paul Gibbons ◽  
...  
Keyword(s):  
Crystal Engineering ◽  
Pulmonary Surfactant ◽  
Surfactant Monolayers ◽  
Salbutamol Sulphate
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