Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal

CrystEngComm ◽  
2017 ◽  
Vol 19 (8) ◽  
pp. 1156-1159 ◽  
Author(s):  
Hiroyuki Yamashita ◽  
Changquan Calvin Sun
Keyword(s):  
Carbamazepine Dihydrate

scholarly journals Revealing the early stages of carbamazepine crystallization by cryoTEM and 3D electron diffraction

IUCrJ ◽  
2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Edward T. Broadhurst ◽  
Hongyi Xu ◽  
Simon Parsons ◽  
Fabio Nudelman
Keyword(s):  
Phase Separation ◽  
Electron Diffraction ◽  
Early Stage ◽  
Active Pharmaceutical Ingredient ◽  
Time Resolved ◽  
Carbamazepine Dihydrate ◽  
Early Stages ◽  
3D Electron

Time-resolved carbamazepine crystallization from wet ethanol has been monitored using a combination of cryoTEM and 3D electron diffraction. Carbamazepine is shown to crystallize exclusively as a dihydrate after 180 s. When the timescale was reduced to 30 s, three further polymorphs could be identified. At 20 s, the development of early stage carbamazepine dihydrate was observed through phase separation. This work reveals two possible crystallization pathways present in this active pharmaceutical ingredient.

scholarly journals Assessment of impact breakage of carbamazepine dihydrate due to aerodynamic dispersion

2019 ◽  
Vol 572 ◽  
pp. 118780
Author(s):  
Wei Pin Goh ◽  
Muzammil Ali ◽  
Kushal Sinha ◽  
Nandkishor K. Nere ◽  
Raimundo Ho ◽  
...  
Keyword(s):  
Carbamazepine Dihydrate

Quantitative analyses of complex pharmaceutical mixtures by the Rietveld method

2001 ◽  
Vol 16 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Sampath S. Iyengar ◽  
Neelima V. Phadnis ◽  
Raj Suryanarayanan
Keyword(s):  
Lithium Fluoride ◽  
Goodness Of Fit ◽  
Rietveld Method ◽  
Internal Standard ◽  
Model System ◽  
Analyte Concentration ◽  
Xrd Pattern ◽  
X Ray ◽  
Carbamazepine Dihydrate ◽  
Quantitative Analyses

The object was to perform simultaneous quantitative analyses of complex pharmaceutical solid mixtures by the Rietveld method. Mixtures consisting of anhydrous β-carbamazepine, anhydrous α-carbamazepine, and carbamazepine dihydrate were chosen as the model system. Lithium fluoride was used as the internal standard. Mixtures of various compositions were prepared and subjected to X-ray powder diffractometry (XRD). The XRD pattern of each mixture was analyzed by the Rietveld method and at the end of the refinement, the goodness of fit was evaluated. When the analyte concentration was high (≥20%), the relative error in the determination was <±5%. The detection of analyte was possible even when its concentration was low (<1% w/w). A unique advantage of the method is that it enables simultaneous quantitative analyses of multiple phases without the requirement of “standard curves.” © 2001 International Centre for Diffraction Data.

scholarly journals PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN

2017 ◽  
Vol 9 (10) ◽  
pp. 318
Author(s):  
Sharwaree Hardikar ◽  
Ashok Bhosale ◽  
Swati Vanave ◽  
Bhagyashree Kamathe
Keyword(s):  
Phase Transformation ◽  
Hydrogen Bonding ◽  
Aqueous Medium ◽  
Crystal Formation ◽  
Ftir Study ◽  
Carbamazepine Dihydrate ◽  
Dissolution Efficiency ◽  
Preparation And Evaluation

Objective: The objective of the present work was to inhibit transformation of carbamazepine anhydrous to its dihydrate form in aqueous medium by adopting the co-crystal approach.Methods: Co-crystallization of carbamazepine and glucomannan as co-former was carried out by solution mediated phase transformation. The solution of carbamazepine and glucomannan in ethanol (95%) was agitated for 2 h and the co-crystals obtained were recovered after 24 h.Results: Co-crystal formation due to hydrogen bonding between carbamazepine and glucomannan as a co-former was confirmed by FTIR study. Inhibition of transformation of co-crystal of carbamazepine to carbamazepine dihydrate in aqueous medium was confirmed by SEM.Conclusion: Inhibition of transformation of carbamazepine co-crystal to its dihydrate form resulted in its improved dissolution. Dissolution efficiency of carbamazepine in its co-crystal was increased up to 79.26% within 30 min.

scholarly journals Solid-vapor interactions: Influence of environmental conditions on the dehydration of carbamazepine dihydrate

2003 ◽  
Vol 4 (4) ◽  
pp. 539-548 ◽  
Author(s):  
Rahul Surana ◽  
Abira Pyne ◽  
Raj Suryanarayanan
Keyword(s):  
Environmental Conditions ◽  
Carbamazepine Dihydrate

In Situ Dehydration of Carbamazepine Dihydrate: A Novel Technique to Prepare Amorphous Anhydrous Carbamazepine

2000 ◽  
Vol 5 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Yinghua Li ◽  
Jun Han ◽  
Geoff G. Z. Zhang ◽  
David J. W. Grant ◽  
Raj Suryanarayanan
Keyword(s):  
Carbamazepine Dihydrate ◽  
Novel Technique

Process-induced phase transformation of carbamazepine dihydrate to its polymorphic anhydrates

2013 ◽  
Vol 236 ◽  
pp. 114-121 ◽  
Author(s):  
Ji Yi Khoo ◽  
Umang V. Shah ◽  
Marc Schaepertoens ◽  
Daryl R. Williams ◽  
Jerry Y.Y. Heng
Keyword(s):  
Phase Transformation ◽  
Carbamazepine Dihydrate
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