scholarly journals Complex chromene derivatives through a silver-catalysed cascade reaction of simple o-alkynylsalicylaldehydes and alkenes

2016 ◽  
Vol 52 (91) ◽  
pp. 13405-13408 ◽  
Author(s):  
Tamara Arto ◽  
Patricia Fernández ◽  
Francisco J. Fañanás ◽  
Félix Rodríguez
Keyword(s):  
Cascade Reaction ◽  
Cyclization Reactions ◽  
Silver Triflate ◽  
Complex Transformation

Silver triflate catalyses a complex transformation of simple ortho-alkynylsalicylaldehydes and alkenes to give benzo[de]chromenyl ketones in a process that involves two formal [4+2]-cyclization reactions.

A Route to Highly Functionalized Stereospecific trans-Aminated Aurones from 3-Bromoflavones with Aniline and N-Phenylurea via a Domino Aza-Michael Ring Opening and Cyclization Reactions

Synthesis ◽  
2018 ◽  
Vol 51 (04) ◽  
pp. 960-970 ◽  
Author(s):  
Naseem Ahmed ◽  
Iram Parveen
Keyword(s):  
Michael Addition ◽  
Ring Opening ◽  
Cascade Reaction ◽  
Cyclization Reactions ◽  
Reaction Conditions ◽  
Aniline Derivatives

A facile cascade reaction is reported via aza-Michael addition, ring opening, and cyclization between 3-bromoflavone and aniline derivatives or N-phenylurea in the presence of KOt-Bu and CuI in DMF under mild reaction conditions. Products were obtained as stereospecific trans-aminated aurones in good to excellent yields (61–83%). Our protocol is operationally successful with ease, avoids the requirement of additives and ligands, and offers broad substrate scope.

scholarly journals Efficient Synthesis of Isoquinoline Derivatives through Sequential Cyclization–Deoxygenation Reaction of 2-Alkynylbenzaldoximes

SynOpen ◽  
2022 ◽  
Vol 06 (01) ◽  
pp. 11-15
Author(s):  
Saeed Balalaie ◽  
Mojtaba Ayoubi ◽  
Ali Nikbakht ◽  
Kamran Amiri ◽  
Alireza Abbasi Kejani ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Cyclization Reactions ◽  
Cyclic Nitrones ◽  
Silver Triflate ◽  
High Yields ◽  
Isoquinoline Derivatives

AbstractWe describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of cyclic nitrones through 6-endo-dig cyclization was achieved using silver triflate or bromine as an electrophile, and subsequently, the deoxygenation process was carried out in the presence of CS2 in good to high yields.

Syntheses of Diverse Natural Products via Dual-Mode Lewis Acid Induced Cascade Cyclization Reactions

Synlett ◽  
2017 ◽  
Vol 28 (12) ◽  
pp. 1394-1406 ◽  
Author(s):  
Chi-Sing Lee ◽  
Guangyan Du ◽  
Gaopeng Wang ◽  
Wenjing Ma ◽  
Qianqian Yang ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Lewis Acids ◽  
First Generation ◽  
Cascade Reaction ◽  
Diels Alder ◽  
Natural Product Synthesis ◽  
Cyclization Reactions ◽  
Dual Mode ◽  
Binding Properties ◽  
Cascade Cyclization

The σ/π-binding properties of a series of Lewis acids was studied using DFT calculations. The results led to the identification of Zn(II)/In(III) as a suitable dual-mode Lewis acid for use in promoting cascade cyclization reactions. Based on this finding, we developed three new types of dual-mode Lewis acid induced cascade cyclization reactions and have demonstrated the utilities of each process in natural product synthesis.1 Introduction2 Dual-Mode Lewis Acids3 Prins/Conia-Ene Cascade Reaction and its Applications4 Diels–Alder/Carbocyclization Cascade Reaction and Applications4.1 First Generation Diels–Alder/Carbocyclization Cascade Reaction and its Application4.2 Second Generation Diels–Alder/Carbocyclization Cascade Reaction and its Applications5 Michael/Conia-Ene Cascade Reaction and its Applications6 Conclusion

scholarly journals Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction

2019 ◽  
Vol 55 (49) ◽  
pp. 7013-7016 ◽  
Author(s):  
Michaelyn C. Lux ◽  
Melissa L. Boby ◽  
Joshua L. Brooks ◽  
Derek S. Tan
Keyword(s):  
Cascade Reaction ◽  
Oxidative Cyclization ◽  
Cyclization Reactions ◽  
Palladium Catalyzed ◽  
Remote Sites

A redox-relay process links two successive Pd-catalyzed cyclization reactions at remote sites to afford bicyclic ether products from readily available linear diene–diol substrates.

Mechanistic Study and Development of Catalytic Reactions of Sm(II)

2018 ◽  
Author(s):  
Sandepan Maity ◽  
Robert Flowers
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Proton Donor ◽  
Catalytic Reactions ◽  
Mechanistic Study ◽  
Mechanistic Studies ◽  
Cyclization Reactions ◽  
Mechanistic Approach ◽  
Donor Source

Despite the broad utility and application of SmI<sub>2</sub>in synthesis, the reagent is used in stoichiometric amounts and has a high molecular weight, resulting in a large amount of material being used for reactions requiring one or more equivalents of electrons. We report mechanistic studies on catalytic reactions of Sm(II) employing a terminal magnesium reductant and trimethyl silyl chloride in concert with a non-coordinating proton donor source. Reactions using this approach permitted reductions with as little as 1 mol% Sm. The mechanistic approach enabled catalysis employing HMPA as a ligand, facilitating the development of catalytic Sm(II) 5-<i>exo</i>-<i>trig </i>ketyl olefin cyclization reactions.

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