Molecular tuning of amino acids to form two-dimensional molecular networks driven by conformational preorganization

2016 ◽  
Vol 52 (97) ◽  
pp. 14055-14058 ◽  
Author(s):  
Young-Sang Youn ◽  
Aram Jeon ◽  
Do Hwan Kim ◽  
Hee-Seung Lee ◽  
Sehun Kim
Keyword(s):  
Amino Acids ◽  
Dft Calculations ◽  
Self Assembly ◽  
Intramolecular Interaction ◽  
The Self ◽  
Molecular Network ◽  
Molecular Networks ◽  
Two Dimensional ◽  
Self Assembled ◽  
Self Association

We investigated the self-assembly of rationally designed γ-Phe on Au(111) using STM with DFT calculations. In contrast to α-Phe, γ-Phe self-assembled into 2D molecular network. The better self-association was attributed to conformational preorganization through intramolecular interaction.

Co-assembly of helical β3-peptides: a self-assembled analogue of a statistical copolymer

2017 ◽  
Vol 89 (12) ◽  
pp. 1809-1816 ◽  
Author(s):  
Claire Buchanan ◽  
Christopher J. Garvey ◽  
Patrick Perlmutter ◽  
Adam Mechler
Keyword(s):  
Amino Acids ◽  
Physical Properties ◽  
Self Assembly ◽  
Unnatural Amino Acids ◽  
The Self ◽  
Microscopy Imaging ◽  
Wide Range ◽  
Self Assembled ◽  
Unnatural Peptides ◽  
Natural Amino Acids

AbstractUnnatural peptide self-assembly offers the means to design hierarchical nanostructures of controlled geometries, chemical function and physical properties. N-acyl β3 peptides, where all residues are unnatural amino acids, are able to form helical fibrous structures by a head-to-tail assembly of helical monomers, extending the helix via a three point supramolecular hydrogen bonding motif. These helical nanorods were shown to be stable under a wide range of physical conditions, offering a self-assembled analogue of polymeric fibres. Hitherto the self-assembly has only been demonstrated between identical monomers; however the self-assembly motif is sequence-independent, offering the possibility of hetero-assembly of different peptide monomers. Here we present a proof of principle study of head-to-tail co-assembly of two different helical unnatural peptides Ac-β3[WELWEL] and Ac-β3[LIA], where the letters denote the β3 analogues of natural amino acids. By atomic force microscopy imaging it was demonstrated that the homo-assembly and co-assembly of these peptides yield characteristically different structures. Synchrotron small angle X-ray scattering experiments have confirmed the presence of the fibres in the solution and the averaged diameters from modelled data correlate well to the results of AFM imaging. Hence, there is evidence of co-assembly of the fibrous superstructures; given that different monomers may be used to introduce variations into chemical and physical properties, the results demonstrate a self-assembled analogue of a statistical co-polymer that can be used in designing complex functional nanomaterials.

Self-assembled atomically thin hybrid conjugated polymer perovskites with two-dimensional structure

2018 ◽  
Vol 6 (31) ◽  
pp. 8405-8410 ◽  
Author(s):  
Furkan H. Isikgor ◽  
Chilla Damodara Reddy ◽  
Mengsha Li ◽  
Hikmet Coskun ◽  
Bichen Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Conjugated Polymer ◽  
The Self ◽  
Dimensional Structure ◽  
Two Dimensional ◽  
Self Assembled

2D hybrid perovskites are formed through the self assembly of polyaniline with PbI6 octahedra.

Self-Assembled Optical Gratings with Banana-Shaped Liquid Crystals

2010 ◽  
Vol 428-429 ◽  
pp. 12-23 ◽  
Author(s):  
Yuan Ming Huang
Keyword(s):  
Liquid Crystals ◽  
Self Assembly ◽  
Red Light ◽  
Diffraction Gratings ◽  
The Self ◽  
Two Dimensional ◽  
Glass Substrates ◽  
Self Assembled ◽  
Optical Gratings ◽  
Diffraction Patterns

We demonstrated that a homologous series of banana-shaped liquid crystals, 1,3-phenylene bis(4-alkyloxybenzylideneamine), could assemble themselves into various kinds of groove-free diffraction gratings when their isotropic melts were slowly cooled into mesophases between two pieces of glass substrates. The groove-free diffraction gratings included one-dimensional parallel gratings, two-dimensional crossed gratings, two-dimensional fan-shaped gratings and two-dimensional circular gratings. Characterization by means of polarized optical microscopy showed that a pattern of periodic modulation of the refractive index was developed in the thin films formed by the banana-shaped compound. Our laser light diffraction experiments confirmed that these groove-free gratings could effectively diffract the incident red light from a helium-neon laser. On the basis of the diffraction equations derived for the self-assembled groove-free optical gratings, the diffraction patterns were simulated for the parallel gratings, orthogonally crossed gratings, fan-shaped gratings and circular gratings, respectively, and good agreement was achieved. The mechanisms on the self-assembly of the banana-shaped molecules were discussed in terms of intermolecular interactions. Our work provides an alternative method for manufacturing diffraction gratings by harnessing the self-assembly of banana-shaped molecules.

scholarly journals Immunoactivity of self-assembled antibodies investigated by atomic force microscopy

RSC Advances ◽  
2018 ◽  
Vol 8 (51) ◽  
pp. 29378-29384 ◽  
Author(s):  
Hiroaki Kominami ◽  
Kei Kobayashi ◽  
Shinichiro Ido ◽  
Hirokazu Kimiya ◽  
Hirofumi Yamada
Keyword(s):  
Atomic Force Microscopy ◽  
Self Assembly ◽  
The Self ◽  
Two Dimensional ◽  
Igg Antibodies ◽  
Association Rate Constant ◽  
Association Rate ◽  
Force Microscopy ◽  
Atomic Force ◽  
Self Assembled

We investigated self-assembly such as hexamerization and two-dimensional crystallization of immunoglobulin G (IgG) molecules on mica by atomic force microscopy. We also estimated the association rate constant of the self-assembled IgG antibodies.

Understanding the self-ordering of amino acids into supramolecular architects: Co-assembly based modulation of phenylalanine nanofibrils

2021 ◽  
Author(s):  
Prabhjot Singh ◽  
Satish Kumar Pandey ◽  
Aarzoo Grover ◽  
Rohit K. Sharma ◽  
Nishima Wangoo
Keyword(s):  
Amino Acids ◽  
Thermodynamic Stability ◽  
Self Assembly ◽  
Functional Materials ◽  
The Self ◽  
Self Assembled ◽  
Bio Compatibility

Amino acids have emerged as promising molecular frameworks for the generation of functional materials owing to the bio-compatibility and thermodynamic stability of their self-assembled architects. The homogeneous and heterogeneous self-assembly...

scholarly journals Self-assembly of amino acids toward functional biomaterials

2021 ◽  
Vol 12 ◽  
pp. 1140-1150
Author(s):  
Huan Ren ◽  
Lifang Wu ◽  
Lina Tan ◽  
Yanni Bao ◽  
Yuchen Ma ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Self Assembly ◽  
Functional Materials ◽  
Building Blocks ◽  
The Self ◽  
Self Assembled ◽  
Functional Biomaterials ◽  
Proteins And Peptides

Biomolecules, such as proteins and peptides, can be self-assembled. They are widely distributed, easy to obtain, and biocompatible. However, the self-assembly of proteins and peptides has disadvantages, such as difficulty in obtaining high quantities of materials, high cost, polydispersity, and purification limitations. The difficulties in using proteins and peptides as functional materials make it more complicate to arrange assembled nanostructures at both microscopic and macroscopic scales. Amino acids, as the smallest constituent of proteins and the smallest constituent in the bottom-up approach, are the smallest building blocks that can be self-assembled. The self-assembly of single amino acids has the advantages of low synthesis cost, simple modeling, excellent biocompatibility and biodegradability in vivo. In addition, amino acids can be assembled with other components to meet multiple scientific needs. However, using these simple building blocks to design attractive materials remains a challenge due to the simplicity of the amino acids. Most of the review articles about self-assembly focus on large molecules, such as peptides and proteins. The preparation of complicated materials by self-assembly of amino acids has not yet been evaluated. Therefore, it is of great significance to systematically summarize the literature of amino acid self-assembly. This article reviews the recent advances in amino acid self-assembly regarding amino acid self-assembly, functional amino acid self-assembly, amino acid coordination self-assembly, and amino acid regulatory functional molecule self-assembly.

Nanoscale Self-Assembly Using Ion and Electron Beam Techniques: A Rapid Review

MRS Advances ◽  
2020 ◽  
Vol 5 (64) ◽  
pp. 3507-3520
Author(s):  
Chunhui Dai ◽  
Kriti Agarwal ◽  
Jeong-Hyun Cho
Keyword(s):  
Electron Beam ◽  
Self Assembly ◽  
Ion Beam ◽  
Three Dimensional ◽  
The Self ◽  
Stress Generation ◽  
Rapid Review ◽  
High Yield ◽  
3D Nanostructures ◽  
Self Assembled

AbstractNanoscale self-assembly, as a technique to transform two-dimensional (2D) planar patterns into three-dimensional (3D) nanoscale architectures, has achieved tremendous success in the past decade. However, an assembly process at nanoscale is easily affected by small unavoidable variations in sample conditions and reaction environment, resulting in a low yield. Recently, in-situ monitored self-assembly based on ion and electron irradiation has stood out as a promising candidate to overcome this limitation. The usage of ion and electron beam allows stress generation and real-time observation simultaneously, which significantly enhances the controllability of self-assembly. This enables the realization of various complex 3D nanostructures with a high yield. The additional dimension of the self-assembled 3D nanostructures opens the possibility to explore novel properties that cannot be demonstrated in 2D planar patterns. Here, we present a rapid review on the recent achievements and challenges in nanoscale self-assembly using electron and ion beam techniques, followed by a discussion of the novel optical properties achieved in the self-assembled 3D nanostructures.

Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

2020 ◽  
Vol 27 (9) ◽  
pp. 923-929
Author(s):  
Gaurav Pandey ◽  
Prem Prakash Das ◽  
Vibin Ramakrishnan
Keyword(s):  
Electron Microscopy ◽  
Amino Acids ◽  
Light Scattering ◽  
Chain Length ◽  
Self Assembly ◽  
The Self ◽  
Ionic Charge ◽  
Self Assembling ◽  
Biophysical Techniques

Background: RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self-assembling peptide, forming hydrogel, used to create defined threedimensional microenvironments for cell culture applications. Objectives: In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. Methods: We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Through a combination of various biophysical methods including thioflavin T fluorescence assay, static right angle light scattering assay, Dynamic Light Scattering (DLS), electron microscopy, CD, and IR spectroscopy, we have examined the role of chain-length on the self-assembly of RADA peptide. Results: Our observations show that the aggregation of ionic, charge-complementary RADA motifcontaining peptides is length-dependent, with N less than 3 are not forming spontaneous selfassemblies. Conclusion: The six biophysical experiments discussed in this paper validate the significance of chain-length on the epitaxial growth of RADA peptide self-assembly.

scholarly journals Self-Assembly of Shape-Tunable Oblate Colloidal Particles into Orientationally Ordered Crystals, Glassy Crystals and Plastic Crystals

Soft Matter ◽  
2021 ◽  
Author(s):  
Jiawei Lu ◽  
Xiangyu Bu ◽  
Xinghua Zhang ◽  
Bing Liu
Keyword(s):  
Crystal Structures ◽  
Self Assembly ◽  
Colloidal Particles ◽  
Building Blocks ◽  
Fundamental Question ◽  
The Self ◽  
Plastic Crystals ◽  
Self Assembled ◽  
Glassy Crystals ◽  
The Relationship

The shapes of colloidal particles are crucial to the self-assembled superstructures. Understanding the relationship between the shapes of building blocks and the resulting crystal structures is an important fundamental question....

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