“Smart” gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification via pH-induced aggregation

2016 ◽  
Vol 52 (53) ◽  
pp. 8287-8290 ◽  
Author(s):  
Jaejung Song ◽  
Jeesu Kim ◽  
Sekyu Hwang ◽  
Mansik Jeon ◽  
Sanghwa Jeong ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agent ◽  
Signal Amplification ◽  
Photoacoustic Imaging ◽  
Imaging Agent ◽  
Cancer Microenvironment ◽  
Ph Responsive ◽  
Induced Aggregation ◽  
Imaging Contrast Agent

pH-Responsive “smart” gold nanoparticles were demonstrated as a new photoacoustic imaging agent that can selectively respond to the cancer microenvironment and show the amplified signal in vivo.

Antimonene Nanoflakes as a Photoacoustic Imaging Contrast Agent for Tumor in vivo Imaging

2020 ◽  
Vol 47 (2) ◽  
pp. 0207033
Author(s):  
于静文 Yu Jingwen ◽  
王秀翃 Wang Xiuhong ◽  
冯金超 Feng Jinchao ◽  
张娜 Zhang Na ◽  
王璞 Wang Pu
Keyword(s):  
Contrast Agent ◽  
In Vivo Imaging ◽  
Photoacoustic Imaging ◽  
Imaging Contrast Agent

In vivo photoacoustic imaging of tumor using gold nanoparticles as contrast agent

2010 ◽  
Author(s):  
Qizhi Zhang ◽  
Nobutaka Iwakuma ◽  
Parvesh Sharma ◽  
Brij M. Moudgil ◽  
Stephen R. Grobmyer ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agent ◽  
Photoacoustic Imaging

scholarly journals pH-responsive targeted gold nanoparticles for in vivo photoacoustic imaging of tumor microenvironments

2019 ◽  
Vol 1 (2) ◽  
pp. 554-564 ◽  
Author(s):  
Shiying Li ◽  
Kwok-Ho Lui ◽  
Tik-Hung Tsoi ◽  
Wai-Sum Lo ◽  
Xin Li ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photoacoustic Imaging ◽  
Ph Responsive ◽  
Tumor Microenvironments

Stable, tumor-specific and pH-responsive gold nanoparticles are carefully designed for aggregation-induced photoacoustic in vivo imaging.

scholarly journals Retraction: Radio frequency triggered curcumin delivery from thermo and pH responsive nanoparticles containing gold nanoparticles and its in vivo localization studies in an orthotopic breast tumor model

RSC Advances ◽  
2020 ◽  
Vol 10 (48) ◽  
pp. 28483-28483
Author(s):  
N. Sanoj Rejinold ◽  
Reju George Thomas ◽  
Muthunarayanan Muthiah ◽  
K. P. Chennazhi ◽  
In-Kyu Park ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Radio Frequency ◽  
Breast Tumor ◽  
Tumor Model ◽  
Ph Responsive ◽  
Breast Tumor Model

Retraction of ‘Radio frequency triggered curcumin delivery from thermo and pH responsive nanoparticles containing gold nanoparticles and its in vivo localization studies in an orthotopic breast tumor model’ by N. Sanoj Rejinold et al., RSC Adv., 2014, 4, 39408–39427, DOI: 10.1039/C4RA05727A.

scholarly journals Photoacoustic Properties of Polypyrrole Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2457
Author(s):  
Peter Keša ◽  
Monika Paúrová ◽  
Michal Babič ◽  
Tomáš Heizer ◽  
Petr Matouš ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Photoacoustic Imaging ◽  
Particle Surface ◽  
Photoacoustic Signal ◽  
Ammonium Persulphate ◽  
Coated Nanoparticles ◽  
Polypyrrole Nanoparticles ◽  
Signal Dependence

Photoacoustic imaging, an emerging modality, provides supplemental information to ultrasound imaging. We investigated the properties of polypyrrole nanoparticles, which considerably enhance contrast in photoacoustic images, in relation to the synthesis procedure and to their size. We prepared polypyrrole nanoparticles by water-based redox precipitation polymerization in the presence of ammonium persulphate (ratio nPy:nOxi 1:0.5, 1:1, 1:2, 1:3, 1:5) or iron(III) chloride (nPy:nOxi 1:2.3) acting as an oxidant. To stabilize growing nanoparticles, non-ionic polyvinylpyrrolidone was used. The nanoparticles were characterized and tested as a photoacoustic contrast agent in vitro on an imaging platform combining ultrasound and photoacoustic imaging. High photoacoustic signals were obtained with lower ratios of the oxidant (nPy:nAPS ≥ 1:2), which corresponded to higher number of conjugated bonds in the polymer. The increasing portion of oxidized structures probably shifted the absorption spectra towards shorter wavelengths. A strong photoacoustic signal dependence on the nanoparticle size was revealed; the signal linearly increased with particle surface. Coated nanoparticles were also tested in vivo on a mouse model. To conclude, polypyrrole nanoparticles represent a promising contrast agent for photoacoustic imaging. Variations in the preparation result in varying photoacoustic properties related to their structure and allow to optimize the nanoparticles for in vivo imaging.

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2–T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

2019 ◽  
Vol 55 (4) ◽  
pp. 478-481 ◽  
Author(s):  
Jiaomin Lin ◽  
Pengyan Xin ◽  
Lu An ◽  
Yanjun Xu ◽  
Cheng Tao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Tumor Imaging ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Contrast ◽  
Imaging Contrast Agent

Fe3O4 nanoparticles were assembled into a zeolitic-imidazole framework to form a pH- and glutathione-responsive T2–T1 switching contrast agent for sensitive tumor imaging.

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