Dynamic resolution of 2-cyclohexylidene acetaldehydes through organocatalytic dienamine [4+2] cycloaddition

2016 ◽  
Vol 52 (44) ◽  
pp. 7153-7156 ◽  
Author(s):  
Jakob Blom ◽  
Tore Kiilerich Johansen ◽  
Frank Jensen ◽  
Karl Anker Jørgensen
Keyword(s):  
Dynamic Resolution

Organocatalytic formed dienamines are shown to be involved in dynamic resolution of 2-cyclohexylidene acetaldehydes.

An Efficient and Scalable Synthesis of the Endothelin Antagonists UK-350,926 and UK-349,862 Using a Dynamic Resolution Process

2005 ◽  
Vol 9 (5) ◽  
pp. 663-669 ◽  
Author(s):  
Christopher P. Ashcroft ◽  
Stephen Challenger ◽  
David Clifford ◽  
Andrew M. Derrick ◽  
Yousef Hajikarimian ◽  
...  
Keyword(s):  
Resolution Process ◽  
Endothelin Antagonists ◽  
Dynamic Resolution ◽  
Scalable Synthesis

scholarly journals The Action Dynamics of Approach-Avoidance Conflict in Decision-Making: A mouse-tracking study

2019 ◽  
Author(s):  
Santiago Garcia-Guerrero ◽  
Denis O'Hora ◽  
Arkady Zgonnikov ◽  
Stefan Scherbaum
Keyword(s):  
Time Course ◽  
Mouse Tracking ◽  
Approach And Avoidance ◽  
Response Options ◽  
Shortest Route ◽  
Dynamic Resolution ◽  
Action Dynamics ◽  
Aversive Consequence ◽  
Approach Avoidance ◽  
Continuous Dynamic

Approach-avoidance conflict is observed in the competing motivations towards the benefits and away from the costs of a decision. The current study employs the action dynamics of response motion, via mouse-tracking, in an attempt to characterize the continuous dynamic resolution of such conflicts. Approach-avoidance conflict (AAC) was generated by varying the appetitive consequences of a decision (i.e., point rewards and shorter participation time) in the presence of a simultaneous aversive consequence (i.e., shock probability). In two experiments, we found that AAC differentially affected response trajectories. Overall, approach trajectories were less complex than avoidance trajectories. As approach and avoidance motivations neared equipotentiality, response trajectories were more deflected from the shortest route to the eventual choice. Consistency in the location of approach and avoidance response options reduced variability in performance enabling more sensitive estimates of dynamic conflict. The time course of competing influences on response trajectories including trial-to-trial effects and conflict between approach and avoidance were estimated using regression analyses. We discuss these findings in terms of a dynamic theory of approach-avoidance that we hope will lead to insights of practical relevance in the field of maladaptive avoidance.

Asymmetric Substitutions of 2-Lithiated N-Boc-piperidine and N-Boc-azepine by Dynamic Resolution

2010 ◽  
Vol 16 (13) ◽  
pp. 4082-4090 ◽  
Author(s):  
Iain Coldham ◽  
Sophie Raimbault ◽  
David T. E. Whittaker ◽  
Praful T. Chovatia ◽  
Daniele Leonori ◽  
...  
Keyword(s):  
Dynamic Resolution

scholarly journals Desymmetrization of 2-Cyano-N -tosylbenzylidenimine with Thiols and Organocatalytic Heterocyclization by Dynamic Resolution: Mechanism Investigation

2019 ◽  
Vol 2019 (46) ◽  
pp. 7584-7589
Author(s):  
Amalia Velardo ◽  
Vito Capaccio ◽  
Tonino Caruso ◽  
Antonia Di Mola ◽  
Antonio Massa ◽  
...  
Keyword(s):  
Dynamic Resolution

Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine

2016 ◽  
Vol 52 (7) ◽  
pp. 1354-1357 ◽  
Author(s):  
Peter J. Rayner ◽  
Joshua C. Smith ◽  
Charline Denneval ◽  
Peter O'Brien ◽  
Paul A. Clarke ◽  
...  
Keyword(s):  
Asymmetric Induction ◽  
Fundamental Study ◽  
Chiral Diamine ◽  
Dynamic Resolution

A fundamental study on the mechanism of the s-BuLi/chiral diamine-mediated asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine has revealed that the asymmetric induction is due to a dynamic resolution of configurationally unstable organolithiums.

scholarly journals Dynamic Resolution Selection in Ultrasonic Strain Imaging

2008 ◽  
Vol 34 (5) ◽  
pp. 809-823 ◽  
Author(s):  
Joel E. Lindop ◽  
Graham M. Treece ◽  
Andrew H. Gee ◽  
Richard W. Prager
Keyword(s):  
Strain Imaging ◽  
Dynamic Resolution

Crystallization-Induced Dynamic Resolution of a Diarylmethylamine toward the Synthesis of a Potent TRPM8 Inhibitor

2016 ◽  
Vol 20 (7) ◽  
pp. 1341-1346 ◽  
Author(s):  
Matthew G. Beaver ◽  
Neil F. Langille ◽  
Sheng Cui ◽  
Yuan-Qing Fang ◽  
Matthew M. Bio ◽  
...  
Keyword(s):  
Dynamic Resolution
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