Stealth fast photoswitching of negative photochromic naphthalene-bridged phenoxyl-imidazolyl radical complexes

2016 ◽  
Vol 52 (41) ◽  
pp. 6797-6800 ◽  
Author(s):  
Katsuya Mutoh ◽  
Yoichi Kobayashi ◽  
Yasukazu Hirao ◽  
Takashi Kubo ◽  
Jiro Abe

A novel negative photochromic compound, Np-PIC, shows the fast thermal back reaction in the millisecond time scale.

2017 ◽  
Vol 238 ◽  
pp. 1008-1016 ◽  
Author(s):  
Fleur van Rossem ◽  
Johan G. Bomer ◽  
Hans L. de Boer ◽  
Yawar Abbas ◽  
Eddy de Weerd ◽  
...  

2012 ◽  
Vol 8 (9) ◽  
pp. 2997-3002 ◽  
Author(s):  
Levi C.T. Pierce ◽  
Romelia Salomon-Ferrer ◽  
Cesar Augusto F. de Oliveira ◽  
J. Andrew McCammon ◽  
Ross C. Walker

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Eric H.-L. Chen ◽  
Tony T.-Y. Lu ◽  
Jack C.-C. Hsu ◽  
Yufeng Jane Tseng ◽  
T.-S. Lim ◽  
...  

Author(s):  
Daniela Gandolfi ◽  
Paola Lombardo ◽  
Jonathan Mapelli ◽  
Sergio Solinas ◽  
Egidio D’Angelo

2019 ◽  
Vol 14 (4) ◽  
pp. 407
Author(s):  
Denis Shchepakin ◽  
Leonid Kalachev ◽  
Michael Kavanaugh

Excitatory Amino Acid Transporters (EAATs) operate over wide time scales in the brain. They maintain low ambient concentrations of the primary excitatory amino acid neurotransmitter glutamate, but they also seem to play a significant role in clearing glutamate from the synaptic cleft in the millisecond time-scale process of chemical communication that occurs between neurons. The detailed kinetic mechanisms underlying glutamate uptake and clearance remain incompletely understood. In this work we used a combination of methods to model EAAT kinetics and gain insight into the impact of transport on glutamate dynamics in a general sense. We derive reliable estimates of the turnover rates of the three major EAAT subtypes expressed in the mammalian cerebral cortex. Previous studies have provided transporter kinetic estimates that vary over an order of magnitude. The values obtained in this study are consistent with estimates that suggest the unitary transporter rates are approximately 20-fold slower than the time course of glutamate in the synapse. A combined diffusion/transport model provides a possible mechanism for the apparent discrepancy.


2002 ◽  
Vol 211 (1) ◽  
pp. 157-164
Author(s):  
Y SAKAMOTO ◽  
K KIZAKI ◽  
T MOTOHIRO ◽  
Y YOKOTA ◽  
H SOBUKAWA ◽  
...  

2019 ◽  
Vol 18 (10) ◽  
pp. 2484-2496 ◽  
Author(s):  
Eleonora Consiglieri ◽  
Alexander Gutt ◽  
Wolfgang Gärtner ◽  
Luiz Schubert ◽  
Cristiano Viappiani ◽  
...  

A full scale analysis of the kinetic processes in the μ-to-millisecond time scale for red-and far red-triggered processes in biliverdin-binding bacterial and fungal phytochromes.


Science ◽  
2012 ◽  
Vol 338 (6103) ◽  
pp. 94-97 ◽  
Author(s):  
M. T. J. van Loenhout ◽  
M. V. de Grunt ◽  
C. Dekker

DNA in cells exhibits a supercoiled state in which the double helix is additionally twisted to form extended intertwined loops called plectonemes. Although supercoiling is vital to many cellular processes, its dynamics remain elusive. In this work, we directly visualize the dynamics of individual plectonemes. We observe that multiple plectonemes can be present and that their number depends on applied stretching force and ionic strength. Plectonemes moved along DNA by diffusion or, unexpectedly, by a fast hopping process that facilitated very rapid (<20 milliseconds) long-range plectoneme displacement by nucleating a new plectoneme at a distant position. These observations directly reveal the dynamics of plectonemes and identify a mode of movement that allows long-distance reorganization of the conformation of the genome on a millisecond time scale.


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