Chiral determination and assay of optical isomers in clandestine drug laboratory samples using LC-MSMS

2017 ◽  
Vol 9 (22) ◽  
pp. 3380-3387 ◽  
Author(s):  
A. Popovic ◽  
T. McBriar ◽  
P. He ◽  
A. Beavis
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Optical Isomers

Development of a method for enantioseparation of amphetamine, methamphetamine and methorphan using LC-MSMS with the aid of a chiral stationary phase.

scholarly journals HIGH – PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ENANTIOSEPARATION OF UNDERIVATIZED α-AMINO ACIDS USING CYCLOFRUCTAN – BASED CHIRAL STATIONARY PHASES

2013 ◽  
Vol 12 (2) ◽  
pp. 108-119 ◽  
Author(s):  
Jakub Moravčík ◽  
Katarína Hroboňová
Keyword(s):  
Amino Acids ◽  
Stationary Phase ◽  
Mobile Phase ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
High Performance Liquid Chromatographic ◽  
Optical Isomers ◽  
Chiral Amino Acids

Abstract Chromatographic columns with chiral stationary phases based on chemically - bonded derivatized cyclofructans were evaluated for HPLC enantioresolution of underivatized α-amino acids. The analytical study of chiral separation of these analytes was focused on the selection of suitable chiral stationary phase and mobile phase. Using isopropyl carbamate cyclofructan 6 as a chiral stationary phase, α- amino acid optical isomers were separated. The retention and enantioseparation of chiral amino acids were also influenced by a mobile phase composition. The mixture methanol/acetonitrile/acetic acid/triethylamine (75/25/0.3/0.2 v/v/v/v) was found to be the most effective mobile phase for HPLC separation of studied compounds. HPLC enantioresolution of chiral amino acids was thermodynamically studied. Based on the enthalpy and entropy contribution values calculated from the van´t Hoff equation, HPLC enantioseparation under chosen chromatographic conditions was found to be an enthalpically driven.

Development of an efficient GLC system with a mixed chiral stationary phase and its application to the separation of optical isomers

2001 ◽  
Vol 16 (5) ◽  
pp. 349-352 ◽  
Author(s):  
Shigeyuki Tamogami ◽  
Ken-ichi Awano ◽  
Masayasu Amaike ◽  
Yoshikazu Takagi ◽  
Takeshi Kitahara
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Optical Isomers ◽  
Separation Of Optical Isomers

Chiral drugs separation by a new antibiotics-based chiral stationary phase

2014 ◽  
Author(s):  
Chunye Liu ◽  
Yanqing Miao ◽  
Yihui Guo ◽  
Yinjuan An ◽  
Yunfang Li ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Drugs ◽  
New Antibiotics

Advances in polymer materials as chiral stationary phase

2016 ◽  
Vol 34 (1) ◽  
pp. 34 ◽  
Author(s):  
Rongji DAI ◽  
Huiting WANG ◽  
Weiwei SUN ◽  
Yulin DENG ◽  
Fang LV ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Polymer Materials

Immobilized cellulase (CBH I) as a chiral stationary phase for direct resolution of enantiomers

1990 ◽  
Vol 112 (11) ◽  
pp. 4573-4574 ◽  
Author(s):  
Per Erlandsson ◽  
Ingrid Marle ◽  
Lennart Hansson ◽  
Roland Isaksson ◽  
Goeran Pettersson ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Resolution Of Enantiomers ◽  
Immobilized Cellulase

scholarly journals A Novel Method for the Preparation of a Chiral Stationary Phase Containing an Enantiopure Acridino-18-Crown-6 Ether Selector

2014 ◽  
Vol 53 (3) ◽  
pp. 431-435 ◽  
Author(s):  
T. Nemeth ◽  
S. Levai ◽  
T. F di ◽  
J. Kupai ◽  
G. Turos ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Novel Method
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