An amperometric FIA system with carrier recycling: an environmentally friendly approach for atenolol determination in pharmaceutical formulations

2016 ◽  
Vol 8 (48) ◽  
pp. 8420-8426 ◽  
Author(s):  
M. A. Franco ◽  
D. A. G. Araújo ◽  
L. H. Oliveira ◽  
M. A. G. Trindade ◽  
R. M. Takeuchi ◽  
...  
Keyword(s):  
Environmentally Friendly ◽  
Pharmaceutical Formulations ◽  
Waste Generation ◽  
Carrier Solution ◽  
Reagent Consumption ◽  
Environmentally Friendly Approach

Carrier solution recirculation in an amperometric FIA system allows ATN quantification with very low reagent consumption and waste generation.

Development and Validation of a Green Analytical Method for the Determination of Norfloxacin in Raw Material by FTIR Spectrophotometry

2016 ◽  
Vol 99 (6) ◽  
pp. 1533-1536 ◽  
Author(s):  
Jéssica Sayuri Hisano Natori ◽  
Eliane Gandolpho Tótoli ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Urinary Tract ◽  
Organic Solvents ◽  
Analytical Method ◽  
Environmentally Friendly ◽  
Raw Material ◽  
Waste Generation ◽  
Ftir Spectrophotometry ◽  
Tract Infections ◽  
Development And Validation

Abstract Norfloxacin is a broad-spectrum antimicrobial agent, widely used in humans and animals for the treatment of urinary tract infections. It is a second-generation fluoroquinolone. Several analytical methods to analyze norfloxacin have been described in the literature. However, most of them are complex and require the use of large amounts of organic solvents. This paper describes the development and validation of a green analytical method for the determination of norfloxacin in raw material by FTIR spectrophotometry. This method does not require the use of organic solvents, minimizing waste generation in the process and its environmental impacts. The development of methods that promote the reduction, prevention, or elimination of waste generation has become highly attractive to the pharmaceutical industry because of the growing demand from civil society and government authorities for environmentally friendly products and services. The FTIR spectrophotometry method was validated according to International Conference on Harmonization guidelines, showing adequate linearity (r = 0.9936), precision, accuracy, and robustness. This validated method can be used as an environmentally friendly alternative for the quantification of norfloxacin in raw material in QC routine analysis.

Water-Mediated Strecker Reaction: An Efficient and Environmentally Friendly Approach for the Synthesis of α-Aminonitriles via a Three-Component Condensation

2010 ◽  
Vol 40 (23) ◽  
pp. 3544-3551 ◽  
Author(s):  
Samikannu Ramesh ◽  
Kulanthaivel Sivakumar ◽  
Chiradeep Panja ◽  
Pirama Nayagam Arunachalam ◽  
Appaswami Lalitha
Keyword(s):  
Environmentally Friendly ◽  
Strecker Reaction ◽  
Environmentally Friendly Approach

Efficient synthesis of glycosylamines in solventless conditions promoted by mechanical milling

RSC Advances ◽  
2014 ◽  
Vol 4 (68) ◽  
pp. 36350-36356 ◽  
Author(s):  
Cédric Epoune Lingome ◽  
Gwladys Pourceau ◽  
Virginie Gobert-Deveaux ◽  
Anne Wadouachi
Keyword(s):  
Mechanical Milling ◽  
Environmentally Friendly ◽  
Efficient Synthesis ◽  
Environmentally Friendly Approach

A mecanosynthesis of glycosylamines under solventless conditions was established. This environmentally friendly approach optimized with l-rhamnose, was investigated using a variety of amines and other carbohydrates.

scholarly journals Electrocarboxylation of 1-chloro-(4-isobutylphenyl)ethane with a silver cathode in ionic liquids: an environmentally benign and efficient way to synthesize Ibuprofen

RSC Advances ◽  
2019 ◽  
Vol 9 (26) ◽  
pp. 15115-15123 ◽  
Author(s):  
Silvia Mena ◽  
Jessica Sanchez ◽  
Gonzalo Guirado
Keyword(s):  
Ionic Liquids ◽  
Environmentally Friendly ◽  
Environmentally Benign ◽  
Green Technologies ◽  
Environmentally Friendly Approach ◽  
Silver Cathode

A new more environmentally friendly approach for synthesising Ibuprofen by using green technologies (electrochemistry and ionic liquids) and CO2 feedstock.

scholarly journals Enzymatic Reactions in a Lab-on-Valve System: Cholesterol Evaluations

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2890 ◽  
Author(s):  
Jucineide S. Barbosa ◽  
Marieta L.C. Passos ◽  
M. das Graças A. Korn ◽  
M. Lúcia M.F.S. Saraiva
Keyword(s):  
Cholesterol Oxidase ◽  
Analytical Tool ◽  
Cholesterol Esterase ◽  
Sequential Injection Analysis ◽  
Enzymatic Reactions ◽  
Waste Generation ◽  
Serum Samples ◽  
Real Samples ◽  
Reagent Consumption ◽  
Alternative Methodology

The micro sequential injection analysis / lab-on-valve (µSIA-LOV) system is a miniaturized SIA system resulting from the implementation of a lab-on-valve (LOV) atop of the selection valve. It integrates the detection cell and the sample processing channels into the same device, promoting the reduction of reagent consumption and waste generation, the improvement of the versatility, and the reduction of the time of analysis. All of these characteristics are really relevant to the implementation of enzymatic reactions. Additionally, the evaluation of cholesterol in serum samples is widely relevant in clinical diagnosis, since higher values of cholesterol in human blood are actually an important risk factor for cardiovascular problems. An automatic methodology was developed based on the µSIA-LOV system in order to evaluate its advantages in the implementation of enzymatic reactions performed by cholesterol esterase, cholesterol oxidase and peroxidase. Considering these reactions, the developed methodology was also used for the evaluation of cholesterol in human serum samples, showing reliable and accurate results. The developed methodology presented detection and quantification limits of 1.36 and 4.53 mg dL−1 and a linear range up to 40 mg dL−1. This work confirmed that this µSIA-LOV system is a simple, rapid, versatile, and robust analytical tool for the automatic implementation of enzymatic reactions performed by cholesterol esterase, cholesterol oxidase, and peroxidase. It is also a useful alternative methodology for the routine determinations of cholesterol in real samples, even when compared with other automatic methodologies.

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