A digoxin electrochemical aptasensor using Ag nanoparticle decorated graphene oxide

2016 ◽  
Vol 8 (39) ◽  
pp. 7247-7253 ◽  
Author(s):  
Mohammad Hossein Mashhadizadeh ◽  
Niloofar Naseri ◽  
Masoud A. Mehrgardi
Keyword(s):  
Graphene Oxide ◽  
Biological Samples ◽  
Ag Nanoparticle ◽  
Electrochemical Aptasensor ◽  
Highly Sensitive

In this work, a highly sensitive aptasensor for digoxin determination in biological samples has been introduced.

Reduced graphene oxide/platinum nanoparticles/nafion nanocomposite as a novel 2D electrochemical sensor for voltammetric determination of aliskiren

2017 ◽  
Vol 41 (24) ◽  
pp. 15320-15326 ◽  
Author(s):  
Ali Kemal Ateş ◽  
Engin Er ◽  
Hüseyin Çelikkan ◽  
Nevin Erk
Keyword(s):  
Graphene Oxide ◽  
Electrochemical Sensor ◽  
Reduced Graphene Oxide ◽  
Platinum Nanoparticles ◽  
Biological Samples ◽  
Voltammetric Determination ◽  
Renin Inhibitors ◽  
Reduced Graphene ◽  
Highly Sensitive

A highly sensitive and selective 2D electrochemical sensor based on an rGO/PtNPs/NFN nanocomposite was developed for routine detection of renin inhibitors such as aliskiren in biological samples.

Synthesis of Ag nanoparticle–carbon nanotube–reduced graphene oxide hybrids for highly sensitive non-enzymatic hydrogen peroxide detection

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 39037-39041 ◽  
Author(s):  
Yong Zhang ◽  
Ziying Wang ◽  
Ye Ji ◽  
Sen Liu ◽  
Tong Zhang
Keyword(s):  
Hydrogen Peroxide ◽  
Graphene Oxide ◽  
Carbon Nanotube ◽  
Reduced Graphene Oxide ◽  
Ag Nanoparticle ◽  
Hydrogen Peroxide Detection ◽  
Reduced Graphene ◽  
Highly Sensitive ◽  
Enzymatic Detection ◽  
Sensing Performance

AgNP–CNT–rGO hybrids were successfully prepared and such hybrids exhibited good sensing performance for electrochemical non-enzymatic detection of hydrogen peroxide.

Highly Sensitive Electrochemical Aptasensor for Detection of Glypican-3 Using Hemin-Reduced Graphene Oxide-Platinum Nanoparticles Coupled with Conductive Reduced Graphene Oxide-Gold Nanoparticles

2021 ◽  
Vol 17 (12) ◽  
pp. 2444-2454
Author(s):  
Guiyin Li ◽  
HaiMei Li ◽  
Wei Chen ◽  
Huijiang Chen ◽  
Guanxiong Wu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Low Cost ◽  
Pt Nanoparticles ◽  
Great Promise ◽  
Electrochemical Aptasensor ◽  
Surface Areas ◽  
Reduced Graphene ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

An electrochemical aptasensor for quantitatively detecting glypican-3 (GPC3) was constructed by combining hemin-reduced graphene oxide-platinum (H-rGO-Pt) nanoparticles (NPs) with reduced graphene oxide-gold (rGO-Au) nanoparticles (NPs). Herein, the rGO-Au NPs deposited onto screen-printed electrodes resulted in signal amplification due to their large surface areas. Meanwhile, highly conductive H-rGO-Pt NPs acted as a sensing medium that improved electrical conductivity and as an indicator for monitoring peak current for determination. A GPC3 aptamer (GPC3apt) with a low equilibrium dissociation constant was used as a bio-recognition molecule. GPC3apt specifically captured GPC3 proteins and formed aptamer-GPC3 complexes, which impeded electron transfer and thus hampered the redox signal of hemin in H-rGO-Pt NPs. This developed electrochemical aptasensor showed a linear response to GPC3 (from 0.001 μg/mL to 10 μg/mL) and had a detection limit of 0.001 μg/mL. This work provides a low-cost and highly sensitive detection with and good recovery for GPC3 and holds great promise for the clinical diagnosis of hepatocellular carcinoma.

Ti4+-immobilized chitosan-coated magnetic graphene oxide for the highly selective enrichment of phosphopeptides

2017 ◽  
Vol 9 (3) ◽  
pp. 443-449 ◽  
Author(s):  
Yiman Zhao ◽  
Lingyi Zhang ◽  
Zhanying Chu ◽  
Zhichao Xiong ◽  
Weibing Zhang
Keyword(s):  
Graphene Oxide ◽  
Biological Samples ◽  
Magnetic Graphene Oxide ◽  
Selective Enrichment ◽  
Magnetic Graphene ◽  
Highly Sensitive ◽  
Depth Analysis

For in-depth analysis of phosphorylated proteomics, the highly sensitive and selective capture of phosphopeptides from intricate biological samples is extremely significant.

scholarly journals Computational Design of a Molecularly Imprinted Polymer for the Biomonitoring of the Organophosphorous Metabolite Chlorferron

Biosensors ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 192
Author(s):  
Bakhtiyar Qader ◽  
Issam Hussain ◽  
Mark Baron ◽  
Rebeca Jiménez-Pérez ◽  
Guzmán Gil-Ramírez ◽  
...  
Keyword(s):  
Biological Samples ◽  
Limit Of Detection ◽  
Computational Design ◽  
Signal Change ◽  
Highly Sensitive ◽  
Limit Of Quantitation ◽  
Molecularly Imprinting Polymers ◽  
Mip Sensor ◽  
Parasitic Mites

Coumaphos is an organophosphorus compound used as insecticide and frequently used by beekeepers for the management of parasitic mites. The most important metabolite, chlorferron (CFN), has been identified in biological samples and foodstuff. The need to quickly identify the presence of typical metabolites, as an indication of interaction with coumaphos has driven the need to produce a highly sensitive electrochemical method for chlorferron analysis, based on molecularly imprinting polymers (MIP) technology. It showed irreversible behaviour with mixed diffusion/adsorption-controlled reactions at the electrode surface. A monoelectronic mechanism of reaction for oxidation has also been suggested. The linear range observed was from 0.158 to 75 µM. Median precision in terms of %RSD around 3% was also observed. For DPV, the limit of detection (LOD) and the limit of quantitation (LOQ) for the CFN-MIP were 0.158 µM and 0.48 µM, respectively. The obtained median % recovery was around 98%. The results were also validated to reference values obtained using GC-MS. Urine and human synthetic plasma spiked with CFN were used to demonstrate the usability of the method in biological samples, showing the potential for biomonitoring. The developed imprinted sensor showed maximum signal change less than 16.8% when related metabolites or pesticide were added to the mix, suggesting high selectivity of the MIP sensor toward CFN molecules. The results from in vitro metabolism of CMP analysed also demonstrates the potential for detection and quantification of CFN in environmental samples. The newly developed CFN-MIP sensor offers similar LoDs than chromatographic methods with shorter analysis time.

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