Enhanced hydroxyapatite nanorods formation on graphene oxide nanocomposite as a potential candidate for protein adsorption, pH controlled release and an effective drug delivery platform for cancer therapy

2017 ◽  
Vol 9 (2) ◽  
pp. 240-252 ◽  
Author(s):  
G. Bharath ◽  
B. Swarna Latha ◽  
Edreese H. Alsharaeh ◽  
P. Prakash ◽  
N. Ponpandian
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Loading ◽  
Creatine Phosphate ◽  
Cancer Drug ◽  
Potential Candidate ◽  
Anti Cancer ◽  
Delivery Platform ◽  
Phosphorus Source ◽  
Ph Dependent

Creatine phosphate used as a phosphorus source for synthesis of a HAp/GO nanocomposite toward protein/anti-cancer drug loading and selective pH dependent drug delivery platforms.

Non-covalent modification of graphene oxide nanocomposites with chitosan/dextran and its application in drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 9328-9337 ◽  
Author(s):  
Meng Xie ◽  
Hailin Lei ◽  
Yufeng Zhang ◽  
Yuanguo Xu ◽  
Song Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Self Assembly ◽  
Covalent Modification ◽  
Cancer Drug ◽  
Graphene Oxide Nanosheets ◽  
Drug Delivery Application ◽  
Anti Cancer ◽  
Assembly Technique ◽  
Cancer Drug Delivery

Graphene oxide nanosheets non-covalent functionalized with chitosan/dextran was successfully developed via LbL self-assembly technique for anti-cancer drug delivery application.

Flexible assembly of targeting agents on porous magnetic nano-cargos by inclusion complexation for accurate drug delivery

2017 ◽  
Vol 1 (3) ◽  
pp. 521-529 ◽  
Author(s):  
Dian Li ◽  
Luyan Sun ◽  
Yuting Zhang ◽  
Meng Yu ◽  
Jia Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inclusion Complexation ◽  
Cancer Drug ◽  
Flexible Assembly ◽  
Anti Cancer ◽  
Delivery Platform

Porous magnetic nano-cargos with targeting folate molecules immobilized by inclusion complexation and large inner pores conjugated with anti-cancer drug doxorubicin have been demonstrated as a universal targeting drug delivery platform.

scholarly journals XYLOGLUCAN CONJUGATED FUNCTIONALIZED GRAPHENE OXIDE AS A NANO CARRIER SYSTEM FOR pH RESPONSIVE TARGETED DRUG DELIVERY OF FUCOIDAN

2021 ◽  
pp. 144-153
Author(s):  
K. SONIA ◽  
D. RAJESH ◽  
S. ARUNA SHARMILI ◽  
K. S. MEENA
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Hemolytic Activity ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Potential Candidate ◽  
Functionalized Graphene ◽  
Ph Responsive ◽  
Functionalized Graphene Oxide

Objective: Marine polysaccharides are materializing in the field of biomedicine owing to its promising properties, including high biocompatibility, excellent biodegradability, nontoxic nature, abundance and low cost. Fucoidan (FU), a sulphated marine polysaccharide extracted from brown seaweed, shows a promising application prospect as an anticancer model drug. In order to enhance the stability, biocompatibility and drug loading capacity, xyloglucan was chosen as a targeting ligand, conjugated onto the surface of chitosan functionalized graphene oxide for targeted delivery of fucoidan. Methods: Firstly, Graphene oxide (GO) was prepared by modified Hummer’s method and functionalized with chitosan (CS) via amidation process, further conjugated with xyloglucan (XG). The resulting conjugate, GO-CS-XG, was used to deliver fucoidan through a nanocarrier drug delivery method. The developed GO-CS-XG-FU nanosystem was analyzed for its physiochemical characterization, morphology, hemolytic activity, anti-inflammatory and anticancer activity. Results: The FU loading efficiency and capacity were 75.7% and 83.4%, respectively. XG ligands on the nanoparticle may lead the nanoparticles to actively target cancer cells. Hemolytic activity of the FU-loaded GO-CS-XG nanosystem shows negligible activity, thus making it a potential candidate for biomedical applications. In vitro drug release analysis of FU from GO-CS-XG was lesser at physiological pH but under acidic conditions, it was significantly increased. Results of in vitro cell viability studies indicate that the efficiency of fucoidan was improved upon conjugation with the nanosystem (GO-CS-XG) against human histiocytic lymphoma (U 937) cell line. Conclusion: As a result, we propose a new multifunctional graphene-based targeted platform by using xyloglucan polysaccharide as targeting nanomaterial for pH-responsive anticancer drug delivery with high efficacy.

scholarly journals pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1899 ◽  
Author(s):  
Evgeny Apartsin ◽  
Nadezhda Knauer ◽  
Valeria Arkhipova ◽  
Ekaterina Pashkina ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Smart Vehicles ◽  
New Class ◽  
Self Assembling ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery

Biomaterials ◽  
2013 ◽  
Vol 34 (37) ◽  
pp. 9638-9647 ◽  
Author(s):  
Wenjun Miao ◽  
Gayong Shim ◽  
Choong Mo Kang ◽  
Soondong Lee ◽  
Yearn Seong Choe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Hyaluronic Acid ◽  
Reduced Graphene Oxide ◽  
Cancer Drug ◽  
Graphene Oxide Nanosheets ◽  
Reduced Graphene ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals ZnO Quantum Dots Modified by pH-Activated Charge-Reversal Polymer for Tumor Targeted Drug Delivery

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1272 ◽  
Author(s):  
Yifan Wang ◽  
Liang He ◽  
Bing Yu ◽  
Yang Chen ◽  
Youqing Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Drug Loading ◽  
Cancer Drug ◽  
Charged Surface ◽  
Nano Drug Delivery ◽  
Anti Cancer ◽  
Acidic Extracellular Ph ◽  
Strong Adhesion ◽  
Zno Quantum Dots

In this paper, we reported a pH responsive nano drug delivery system (NDDS) based on ZnO quantum dots (QDs) for controlled release of drugs. Zwitterionic poly(carboxybetaine methacrylate) (PCBMA) and poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) were introduced to modify ZnO QDs, which can help enhance water stability, increase blood circulation time, and promote endocytosis. After tuning of PCBMA/PDMAEMA ratios, the ZnO@P(CBMA-co-DMAEMA) nanoplatform shows a sensitive switch from strong protein adsorption resistance (with negatively charged surface) at physiological pH to strong adhesion to tumor cell membranes (with positively charged surface) at the slightly acidic extracellular pH of tumors. Anti-cancer drug, Doxorubicin (DOX), molecules were demonstrated to be successfully loaded to ZnO@P(CBMA-co-DMAEMA) with a relatively large drug loading content (24.6%). In addition, ZnO@P(CBMA-co-DMAEMA) loaded with DOX can achieve lysosomal acid degradation and release of DOX after endocytosis by tumor cells, resulting in synergistic treatment of cancer, which is attributed to a combination of the anticancer effect of Zn2+ and DOX.

scholarly journals Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer

2021 ◽  
Author(s):  
Houra Nekounam ◽  
Rassoul Dinarvand ◽  
Rahele Khademi ◽  
Fatemeh Asghari ◽  
Narges Mahmoodi ◽  
...  
Keyword(s):  
High Pressure ◽  
Drug Loading ◽  
Hybrid Approach ◽  
Cancer Drug ◽  
Chemical Agent ◽  
Potential Candidate ◽  
Albumin Nanoparticles ◽  
Anti Cancer ◽  
High Pressure Homogenizer ◽  
First Time

Indirubin can be applied as an anti-cancer drug for inhibition of brain tumors. However, its performance is reduced due to hydrophobicity. In this study, we synthesized cationic human serum albumin (CHSA) nanoparticle by a new hybrid approach for improvement the surface chemistry of albumin and investigate the amount of indirubin loaded CHSA nanoparticle. In this study, the generated mechanical force from a high-pressure homogenizer (HPH) was used to make nanoparticles with a certain size with narrow polydispersity. The results indicated that the size of indirubin loaded CHSA nanoparticles were 130 nm and their zeta potential were +9. Besides, the encapsulation efficiency and drug loading capacity were found to be 85% and 5.8 %, respectively. To the best to our knowledge, this is the first time that indirubin has been used in albumin nanoparticles. In this study, indirubin loaded CHSA nanoparticles was shown can be a potential candidate for drug delivery in the treatment of glioblastoma. Moreover, the cationized form allows the chemical agent to be transmitted to the brain.

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