Single plasmonic nanoparticles as ultrasensitive sensors

The Analyst ◽  
2017 ◽  
Vol 142 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Tao Xie ◽  
Chao Jing ◽  
Yi-Tao Long
Keyword(s):  
Real Time ◽  
Living Cells ◽  
Plasmonic Nanoparticles ◽  
Electrochemical Reactions ◽  
Real Time Monitoring ◽  
The Real ◽  
Plasmonic Nanoparticle

In this mini review, we will provide a brief introduction focusing on the current applications of single plasmonic nanoparticle-based sensors using DFM, including the detection of molecules, the real-time monitoring of chemical/electrochemical reactions and the imaging of living cells.

Turn-On Luminescent Probes for the Real-Time Monitoring of Endogenous Hydroxyl Radicals in Living Cells

2016 ◽  
Vol 128 (13) ◽  
pp. 4308-4313 ◽  
Author(s):  
Wenjuan Zhou ◽  
Yuqing Cao ◽  
Dandan Sui ◽  
Chao Lu
Keyword(s):  
Real Time ◽  
Hydroxyl Radicals ◽  
Living Cells ◽  
Real Time Monitoring ◽  
The Real ◽  
Luminescent Probes ◽  
Turn On

scholarly journals Real-time monitoring of newly acidified organelles during autophagy enabled by reaction-based BODIPY dyes

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Hanzhuang Liu ◽  
Wenting Song ◽  
Delia Gröninger ◽  
Lei Zhang ◽  
Yinghong Lu ◽  
...  
Keyword(s):  
Real Time ◽  
Underlying Mechanism ◽  
Living Cells ◽  
Real Time Monitoring ◽  
Nucleophilic Reaction ◽  
The Real ◽  
Reversible Transformation ◽  
Red Fluorescence ◽  
Boron Dipyrromethene ◽  
Acidic Organelles

AbstractReal-time monitoring of newly acidified organelles during autophagy in living cells is highly desirable for a better understanding of intracellular degradative processes. Herein, we describe a reaction-based boron dipyrromethene (BODIPY) dye containing strongly electron-withdrawing diethyl 2-cyanoacrylate groups at the α-positions. The probe exhibits intense red fluorescence in acidic organelles or the acidified cytosol while exhibiting negligible fluorescence in other regions of the cell. The underlying mechanism is a nucleophilic reaction at the central meso-carbon of the indacene core, resulting in the loss of π-conjugation entailed by dramatic spectroscopic changes of more than 200 nm between its colorless, non-fluorescent leuco-BODIPY form and its red and brightly emitting form. The reversible transformation between red fluorescent BODIPY and leuco-BODIPY along with negligible cytotoxicity qualifies such dyes for rapid and direct intracellular lysosome imaging and cytosolic acidosis detection simultaneously without any washing step, enabling the real-time monitoring of newly acidified organelles during autophagy.

A multicolor DNA tetrahedron nanoprobe for analyzing human telomerase in living cells

2021 ◽  
Author(s):  
Ruiyuan Zhang ◽  
Ruixue Zhang ◽  
Wei Jiang ◽  
Xiaowen Xu
Keyword(s):  
Real Time ◽  
Length Distribution ◽  
Telomerase Activity ◽  
Living Cells ◽  
Real Time Monitoring ◽  
Dna Tetrahedron ◽  
Human Telomerase

A sequentially lighting-up multicolor DNA tetrahedron nanoprobe is constructed for imaging telomerase activity, real-time monitoring telomerase action and determining product length distribution in living cells.

A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode

Lab on a Chip ◽  
2017 ◽  
Vol 17 (24) ◽  
pp. 4294-4302 ◽  
Author(s):  
Franziska D. Zitzmann ◽  
Heinz-Georg Jahnke ◽  
Felix Nitschke ◽  
Annette G. Beck-Sickinger ◽  
Bernd Abel ◽  
...  
Keyword(s):  
Real Time ◽  
Microfluidic Chip ◽  
Microelectrode Array ◽  
Fem Simulation ◽  
Receptor Activation ◽  
Living Cells ◽  
Real Time Monitoring ◽  
Non Invasive ◽  
Npy Receptor ◽  
Simulation Based

We present a FEM simulation based step-by-step development of a microelectrode array integrated into a microfluidic chip for the non-invasive real-time monitoring of living cells.

scholarly journals Designing, construction and characterization of genetically encoded FRET-based nanosensor for real time monitoring of lysine flux in living cells

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Seema Ameen ◽  
Mohammad Ahmad ◽  
Mohd. Mohsin ◽  
M. Irfan Qureshi ◽  
Mohamed M. Ibrahim ◽  
...  
Keyword(s):  
Real Time ◽  
Living Cells ◽  
Real Time Monitoring

Observing the real time formation of phosphine-ligated gold clusters by electrospray ionization mass spectrometry

2017 ◽  
Vol 19 (26) ◽  
pp. 17187-17198 ◽  
Author(s):  
Marshall R. Ligare ◽  
Grant E. Johnson ◽  
Julia Laskin
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Real Time ◽  
Electrospray Ionization Mass Spectrometry ◽  
Gold Cluster ◽  
Gold Clusters ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Real Time Monitoring ◽  
The Real

Real-time monitoring of the gold cluster synthesis by electrospray ionization mass spectrometry reveals distinct formation pathways for Au8, Au9 and Au10 clusters.

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